Citation
Ramcharan, Tristan, et al. "Paediatric Inflammatory Multisystem Syndrome: Temporally Associated With SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital." Pediatric Cardiology, vol. 41, no. 7, 2020, pp. 1391-1401.
Ramcharan T, Nolan O, Lai CY, et al. Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital. Pediatr Cardiol. 2020;41(7):1391-1401.
Ramcharan, T., Nolan, O., Lai, C. Y., Prabhu, N., Krishnamurthy, R., Richter, A. G., Jyothish, D., Kanthimathinathan, H. K., Welch, S. B., Hackett, S., Al-Abadi, E., Scholefield, B. R., & Chikermane, A. (2020). Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital. Pediatric Cardiology, 41(7), 1391-1401. https://doi.org/10.1007/s00246-020-02391-2
Ramcharan T, et al. Paediatric Inflammatory Multisystem Syndrome: Temporally Associated With SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital. Pediatr Cardiol. 2020;41(7):1391-1401. PubMed PMID: 32529358.
TY - JOUR
T1 - Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital.
AU - Ramcharan,Tristan,
AU - Nolan,Oscar,
AU - Lai,Chui Yi,
AU - Prabhu,Nanda,
AU - Krishnamurthy,Raghu,
AU - Richter,Alex G,
AU - Jyothish,Deepthi,
AU - Kanthimathinathan,Hari Krishnan,
AU - Welch,Steven B,
AU - Hackett,Scott,
AU - Al-Abadi,Eslam,
AU - Scholefield,Barnaby R,
AU - Chikermane,Ashish,
Y1 - 2020/06/12/
PY - 2020/05/28/received
PY - 2020/06/05/accepted
PY - 2020/6/13/pubmed
PY - 2020/10/22/medline
PY - 2020/6/13/entrez
KW - COVID-19
KW - Hyper-inflammatory
KW - Kawasaki
KW - MIS-C
KW - PIMS-TS
KW - SARS-CoV-2
SP - 1391
EP - 1401
JF - Pediatric cardiology
JO - Pediatr Cardiol
VL - 41
IS - 7
N2 - Children were relatively spared during COVID-19 pandemic. However, the recently reported hyperinflammatory syndrome with overlapping features of Kawasaki disease and toxic shock syndrome-"Paediatric Inflammatory Multisystem Syndrome-temporally associated with SARS-CoV-2" (PIMS-TS) has caused concern. We describe cardiac findings and short-term outcomes in children with PIMS-TS at a tertiary children's hospital. Single-center observational study of children with PIMS-TS from 10th April to 9th May 2020. Data on ECG and echocardiogram were retrospectively analyzed along with demographics, clinical features and blood parameters. Fifteen children with median age of 8.8 (IQR 6.4-11.2) years were included, all were from African/Afro-Caribbean, South Asian, Mixed or other minority ethnic groups. All showed raised inflammatory/cardiac markers (CRP, ferritin, Troponin I, CK and pro-BNP). Transient valve regurgitation was present in 10 patients (67%). Left Ventricular ejection fraction was reduced in 12 (80%), fractional shortening in 8 (53%) with resolution in all but 2. Fourteen (93%) had coronary artery abnormalities, with normalization in 6. ECG abnormalities were present in 9 (60%) which normalized in 6 by discharge. Ten (67%) needed inotropes and/or vasopressors. None needed extracorporeal life support. Improvement in cardiac biochemical markers was closely followed by improvement in ECG/echocardiogram. All patients were discharged alive and twelve (80%) have been reviewed since. Our entire cohort with PIMS-TS had cardiac involvement and this degree of involvement is significantly more than other published series and emphasizes the need for specialist cardiac review. We believe that our multi-disciplinary team approach was crucial for the good short-term outcomes.
SN - 1432-1971
UR - https://www.unboundmedicine.com/medline/citation/32529358/Paediatric_Inflammatory_Multisystem_Syndrome:_Temporally_Associated_with_SARS_CoV_2__PIMS_TS_:_Cardiac_Features_Management_and_Short_Term_Outcomes_at_a_UK_Tertiary_Paediatric_Hospital_
DB - PRIME
DP - Unbound Medicine
ER -