Tags

Type your tag names separated by a space and hit enter

Prognostic values of the clinicopathological characteristics and survival outcomes in micropapillary urothelial carcinoma of the bladder: A SEER database analysis.
Cancer Med. 2020 Jul; 9(14):4897-4906.CM

Abstract

PURPOSE

To study prognostic values of the clinicopathological characteristics and survival outcomes in micropapillary urothelial carcinoma (MPUC) of the urinary bladder.

METHOD

We used the national Surveillance, Epidemiology, and End Results database (2004-2016) to compare MPUC with transitional cell carcinoma (TCC) and to investigate prognostic values of clinicopathological characteristics, as well as survival outcomes, in MPUC of the urinary bladder. A multivariable Cox proportional hazard model, subgroup analyses, and propensity score matching were used.

RESULTS

In all, 519 patients with MPUC and 154 453 patients with TCC were enrolled. Compared with TCC, patients with MPUC had a higher rate of muscle invasive disease (P < .001), lymph node metastasis (P < .001), and distal metastasis (P < .001), as well as higher tumor grade (P < .001). According to the survival analyses, the MPUC group also had lower survival probability in both cancer-specific mortality (CSM) (P < .0001) and overall mortality (OM) analyses (P < .0001). Cox proportional hazard regression showed that the MPUC group had a higher risk of OM (hazard ratios [HR] = 1.39, 95% confidence intervals [CI] = 1.22-1.57, P < .0001), although the CSM (HR = 1.18, 95% CI = 1.00-1.40, P = .0505) in that group was fair. In the subgroup analysis, only MPUC patients without distal metastasis faced a higher risk of CSM (HR = 1.33, 95% CI = 1.101.61, P < .0001).

CONCLUSIONS

Micropapillary urothelial carcinoma prognosis is poorer than that of TCC. Micropapillary urothelial carcinoma is an independent prognostic factor for OM in patients with urinary bladder cancer.

Authors+Show Affiliations

Department of Urology, Institute of Urology, National Clinical Research Center for Geriatrics and Center of Biomedical Big Data, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.Department of Urology, Institute of Urology, National Clinical Research Center for Geriatrics and Center of Biomedical Big Data, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.Department of Urology, Institute of Urology, National Clinical Research Center for Geriatrics and Center of Biomedical Big Data, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.Department of Urology, Institute of Urology, National Clinical Research Center for Geriatrics and Center of Biomedical Big Data, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.Department of Urology, Institute of Urology, National Clinical Research Center for Geriatrics and Center of Biomedical Big Data, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.Department of Urology, Institute of Urology, National Clinical Research Center for Geriatrics and Center of Biomedical Big Data, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.Department of Urology, Institute of Urology, National Clinical Research Center for Geriatrics and Center of Biomedical Big Data, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32529761

Citation

Jin, Di, et al. "Prognostic Values of the Clinicopathological Characteristics and Survival Outcomes in Micropapillary Urothelial Carcinoma of the Bladder: a SEER Database Analysis." Cancer Medicine, vol. 9, no. 14, 2020, pp. 4897-4906.
Jin D, Jin K, Qiu S, et al. Prognostic values of the clinicopathological characteristics and survival outcomes in micropapillary urothelial carcinoma of the bladder: A SEER database analysis. Cancer Med. 2020;9(14):4897-4906.
Jin, D., Jin, K., Qiu, S., Zhou, X., Yuan, Q., Yang, L., & Wei, Q. (2020). Prognostic values of the clinicopathological characteristics and survival outcomes in micropapillary urothelial carcinoma of the bladder: A SEER database analysis. Cancer Medicine, 9(14), 4897-4906. https://doi.org/10.1002/cam4.3147
Jin D, et al. Prognostic Values of the Clinicopathological Characteristics and Survival Outcomes in Micropapillary Urothelial Carcinoma of the Bladder: a SEER Database Analysis. Cancer Med. 2020;9(14):4897-4906. PubMed PMID: 32529761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic values of the clinicopathological characteristics and survival outcomes in micropapillary urothelial carcinoma of the bladder: A SEER database analysis. AU - Jin,Di, AU - Jin,Kun, AU - Qiu,Shi, AU - Zhou,Xianghong, AU - Yuan,Qiming, AU - Yang,Lu, AU - Wei,Qiang, Y1 - 2020/06/11/ PY - 2020/03/02/received PY - 2020/05/04/revised PY - 2020/05/05/accepted PY - 2020/6/13/pubmed PY - 2020/6/13/medline PY - 2020/6/13/entrez KW - SEER Program KW - micropapillary urothelial carcinoma KW - prognosis KW - urinary bladder SP - 4897 EP - 4906 JF - Cancer medicine JO - Cancer Med VL - 9 IS - 14 N2 - PURPOSE: To study prognostic values of the clinicopathological characteristics and survival outcomes in micropapillary urothelial carcinoma (MPUC) of the urinary bladder. METHOD: We used the national Surveillance, Epidemiology, and End Results database (2004-2016) to compare MPUC with transitional cell carcinoma (TCC) and to investigate prognostic values of clinicopathological characteristics, as well as survival outcomes, in MPUC of the urinary bladder. A multivariable Cox proportional hazard model, subgroup analyses, and propensity score matching were used. RESULTS: In all, 519 patients with MPUC and 154 453 patients with TCC were enrolled. Compared with TCC, patients with MPUC had a higher rate of muscle invasive disease (P < .001), lymph node metastasis (P < .001), and distal metastasis (P < .001), as well as higher tumor grade (P < .001). According to the survival analyses, the MPUC group also had lower survival probability in both cancer-specific mortality (CSM) (P < .0001) and overall mortality (OM) analyses (P < .0001). Cox proportional hazard regression showed that the MPUC group had a higher risk of OM (hazard ratios [HR] = 1.39, 95% confidence intervals [CI] = 1.22-1.57, P < .0001), although the CSM (HR = 1.18, 95% CI = 1.00-1.40, P = .0505) in that group was fair. In the subgroup analysis, only MPUC patients without distal metastasis faced a higher risk of CSM (HR = 1.33, 95% CI = 1.101.61, P < .0001). CONCLUSIONS: Micropapillary urothelial carcinoma prognosis is poorer than that of TCC. Micropapillary urothelial carcinoma is an independent prognostic factor for OM in patients with urinary bladder cancer. SN - 2045-7634 UR - https://www.unboundmedicine.com/medline/citation/32529761/Prognostic_values_of_the_clinicopathological_characteristics_and_survival_outcomes_in_micropapillary_urothelial_carcinoma_of_the_bladder:_A_SEER_database_analysis L2 - https://doi.org/10.1002/cam4.3147 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.