Tags

Type your tag names separated by a space and hit enter

SARS-CoV-2 infection of the nervous system: A review of the literature on neurological involvement in novel coronavirus disease-(COVID-19).
Bosn J Basic Med Sci. 2020 Aug 03; 20(3):283-292.BJ

Abstract

The novel coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is believed to have emerged from an animal source and has been spreading rapidly among humans. Recent evidence shows that SARS-CoV-2 exhibits neurotropic properties and causes neurological diseases. Here, we review the literature on neurological involvement in SARS-CoV-2 infections and the possible mechanisms of invasion of the nervous system by this virus, to provide a summary and critical analysis of the early reporting of neurological involvement in COVID-19. An exhaustive search of scientific articles on neurological involvement in COVID-19 was performed in the Web of Science, Scopus, Medline/PubMed, and several other databases. Nineteen relevant articles that had been published or were in preprint were carefully selected according to the inclusion and exclusion criteria. Based on our research, we found that patients with COVID-19 can present with neurological symptoms that can be broadly divided into central nervous system involvement, such as headache, dizziness, altered mental state, and disorientation, and peripheral nervous system involvement, such as anosmia and hypogeusia. Most of these patients are in the older age group and exhibit comorbidities, especially hypertension, and severe infection. In extreme presentations of COVID-19, some patients exhibit seizures, stroke, flaccid paraparesis, corticospinal weakness, and even coma. Moreover, the neurological man-ifestations can occur independently of the respiratory system. In conclusion, SARS-CoV-2 infection can cause multiple neurological syndromes in a more complex presentation. Therefore, this review elucidated the involvement of the nervous system in SARS-CoV-2 infection and will hopefully help improve the management of COVID-19.

Authors+Show Affiliations

Faculty of Medicine and Health Science, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, Malaysia.Faculty of Medicine and Health Science, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, Malaysia.Faculty of Medicine and Health Science, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, Malaysia.Faculty of Medicine and Health Science, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, Malaysia.Department of Internal Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Cheras, Kuala Lumpur, Malaysia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32530389

Citation

Payus, Alvin Oliver, et al. "SARS-CoV-2 Infection of the Nervous System: a Review of the Literature On Neurological Involvement in Novel Coronavirus Disease-(COVID-19)." Bosnian Journal of Basic Medical Sciences, vol. 20, no. 3, 2020, pp. 283-292.
Payus AO, Liew Sat Lin C, Mohd Noh M, et al. SARS-CoV-2 infection of the nervous system: A review of the literature on neurological involvement in novel coronavirus disease-(COVID-19). Bosn J Basic Med Sci. 2020;20(3):283-292.
Payus, A. O., Liew Sat Lin, C., Mohd Noh, M., Jeffree, M. S., & Ali, R. A. (2020). SARS-CoV-2 infection of the nervous system: A review of the literature on neurological involvement in novel coronavirus disease-(COVID-19). Bosnian Journal of Basic Medical Sciences, 20(3), 283-292. https://doi.org/10.17305/bjbms.2020.4860
Payus AO, et al. SARS-CoV-2 Infection of the Nervous System: a Review of the Literature On Neurological Involvement in Novel Coronavirus Disease-(COVID-19). Bosn J Basic Med Sci. 2020 Aug 3;20(3):283-292. PubMed PMID: 32530389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 infection of the nervous system: A review of the literature on neurological involvement in novel coronavirus disease-(COVID-19). AU - Payus,Alvin Oliver, AU - Liew Sat Lin,Constance, AU - Mohd Noh,Malehah, AU - Jeffree,Mohammad Saffree, AU - Ali,Raymond Azman, Y1 - 2020/08/03/ PY - 2020/05/18/received PY - 2020/05/30/accepted PY - 2020/6/13/pubmed PY - 2020/7/18/medline PY - 2020/6/13/entrez SP - 283 EP - 292 JF - Bosnian journal of basic medical sciences JO - Bosn J Basic Med Sci VL - 20 IS - 3 N2 - The novel coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is believed to have emerged from an animal source and has been spreading rapidly among humans. Recent evidence shows that SARS-CoV-2 exhibits neurotropic properties and causes neurological diseases. Here, we review the literature on neurological involvement in SARS-CoV-2 infections and the possible mechanisms of invasion of the nervous system by this virus, to provide a summary and critical analysis of the early reporting of neurological involvement in COVID-19. An exhaustive search of scientific articles on neurological involvement in COVID-19 was performed in the Web of Science, Scopus, Medline/PubMed, and several other databases. Nineteen relevant articles that had been published or were in preprint were carefully selected according to the inclusion and exclusion criteria. Based on our research, we found that patients with COVID-19 can present with neurological symptoms that can be broadly divided into central nervous system involvement, such as headache, dizziness, altered mental state, and disorientation, and peripheral nervous system involvement, such as anosmia and hypogeusia. Most of these patients are in the older age group and exhibit comorbidities, especially hypertension, and severe infection. In extreme presentations of COVID-19, some patients exhibit seizures, stroke, flaccid paraparesis, corticospinal weakness, and even coma. Moreover, the neurological man-ifestations can occur independently of the respiratory system. In conclusion, SARS-CoV-2 infection can cause multiple neurological syndromes in a more complex presentation. Therefore, this review elucidated the involvement of the nervous system in SARS-CoV-2 infection and will hopefully help improve the management of COVID-19. SN - 1840-4812 UR - https://www.unboundmedicine.com/medline/citation/32530389/SARS_CoV_2_infection_of_the_nervous_system:_A_review_of_the_literature_on_neurological_involvement_in_novel_coronavirus_disease__COVID_19__ L2 - https://doi.org/10.17305/bjbms.2020.4860 DB - PRIME DP - Unbound Medicine ER -