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A comparison of the effect of intravitreal dexamethasone implant on macular and branch retinal vein occlusion. A real life experience.
Eur J Ophthalmol. 2020 Sep; 30(5):1106-1111.EJ

Abstract

PURPOSE

This study aimed to compare the effects of intravitreal dexamethasone (IVDx) implants on branch retinal vein occlusions (BRVOs) and macular vein occlusions (MVOs).

METHODS

Seventeen consecutive patients with MVO and 18 patients with BRVO, whose foveal thicknesses were greater than 300 µm, were recruited for this study. BRVO and MVO patients were diagnosed by means of fundus fluorescein angiography. Patients were treatment-naive. Initially, each patient in both the BRVO and MVO groups received an IVDx implant, and then a pro re nata IVDx regimen was initiated. Primary outcomes included VA gain, intraocular pressure (IOP) changes, macular ischemia, central macular thickness, retinal neovascularization, and number of IVDx injections. Follow-up time was 12 months.

RESULTS

The MVO group initially had significantly lower central macular thickness and a lower percentage of macular ischemia and systemic hypertension than those in the BRVO group (p = 0.001, 0.045, and 0.010, respectively). There was a statistically significant VA gain in both groups (p < 0.001), but the VA gain of the MVO group was greater than that of the BRVO group (p < 0.001). The mean total number of IVDx injections administered throughout the study period was significantly lower in the MVO group than in the BRVO group (1.3 ± 0.4 vs 2.0 ± 0.0; p = 0.001).

DISCUSSION

MVO and BRVO have different disease characteristics, and IVDx implants were more effective on the visual gain in patients with MVO than that of patients with BRVO who had higher numbers of IVDx injections.

Authors+Show Affiliations

Department of Ophthalmology, Namık Kemal University School of Medicine, Tekirdağ, Marmara, Turkey.Department of Ophthalmology, Okmeydanı Education and Research Hospital, Istanbul, Turkey.Department of Ophthalmology, Namik Kemal University School of Medicine, Namık Kemal University, Tekirdağ, Turkey.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

32530706

Citation

Sever, Ozkan, et al. "A Comparison of the Effect of Intravitreal Dexamethasone Implant On Macular and Branch Retinal Vein Occlusion. a Real Life Experience." European Journal of Ophthalmology, vol. 30, no. 5, 2020, pp. 1106-1111.
Sever O, Cakir A, Horozoglu F. A comparison of the effect of intravitreal dexamethasone implant on macular and branch retinal vein occlusion. A real life experience. Eur J Ophthalmol. 2020;30(5):1106-1111.
Sever, O., Cakir, A., & Horozoglu, F. (2020). A comparison of the effect of intravitreal dexamethasone implant on macular and branch retinal vein occlusion. A real life experience. European Journal of Ophthalmology, 30(5), 1106-1111. https://doi.org/10.1177/1120672120934982
Sever O, Cakir A, Horozoglu F. A Comparison of the Effect of Intravitreal Dexamethasone Implant On Macular and Branch Retinal Vein Occlusion. a Real Life Experience. Eur J Ophthalmol. 2020;30(5):1106-1111. PubMed PMID: 32530706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of the effect of intravitreal dexamethasone implant on macular and branch retinal vein occlusion. A real life experience. AU - Sever,Ozkan, AU - Cakir,Akin, AU - Horozoglu,Fatih, Y1 - 2020/06/12/ PY - 2020/6/13/pubmed PY - 2020/11/11/medline PY - 2020/6/13/entrez KW - Macular vein occlusion KW - branch retinal vein occlusion KW - macular edema KW - macular ischemia SP - 1106 EP - 1111 JF - European journal of ophthalmology JO - Eur J Ophthalmol VL - 30 IS - 5 N2 - PURPOSE: This study aimed to compare the effects of intravitreal dexamethasone (IVDx) implants on branch retinal vein occlusions (BRVOs) and macular vein occlusions (MVOs). METHODS: Seventeen consecutive patients with MVO and 18 patients with BRVO, whose foveal thicknesses were greater than 300 µm, were recruited for this study. BRVO and MVO patients were diagnosed by means of fundus fluorescein angiography. Patients were treatment-naive. Initially, each patient in both the BRVO and MVO groups received an IVDx implant, and then a pro re nata IVDx regimen was initiated. Primary outcomes included VA gain, intraocular pressure (IOP) changes, macular ischemia, central macular thickness, retinal neovascularization, and number of IVDx injections. Follow-up time was 12 months. RESULTS: The MVO group initially had significantly lower central macular thickness and a lower percentage of macular ischemia and systemic hypertension than those in the BRVO group (p = 0.001, 0.045, and 0.010, respectively). There was a statistically significant VA gain in both groups (p < 0.001), but the VA gain of the MVO group was greater than that of the BRVO group (p < 0.001). The mean total number of IVDx injections administered throughout the study period was significantly lower in the MVO group than in the BRVO group (1.3 ± 0.4 vs 2.0 ± 0.0; p = 0.001). DISCUSSION: MVO and BRVO have different disease characteristics, and IVDx implants were more effective on the visual gain in patients with MVO than that of patients with BRVO who had higher numbers of IVDx injections. SN - 1724-6016 UR - https://www.unboundmedicine.com/medline/citation/32530706/A_comparison_of_the_effect_of_intravitreal_dexamethasone_implant_on_macular_and_branch_retinal_vein_occlusion__A_real_life_experience_ L2 - https://journals.sagepub.com/doi/10.1177/1120672120934982?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -