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Role of the GTNGTKR motif in the N-terminal receptor-binding domain of the SARS-CoV-2 spike protein.
Virus Res. 2020 09; 286:198058.VR

Abstract

The 2019 novel coronavirus disease (COVID-19) that emerged in China has been declared as public health emergency of international concern by the World Health Organization and the causative pathogen was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this report, we analyzed the structural characteristics of the N-terminal domain of the S1 subunit (S1-NTD) of the SARS-CoV-2 spike protein in comparison to the SARS-CoV in particular, and to other viruses presenting similar characteristic in general. Given the severity and the wide and rapid spread of the SARS-CoV-2 infection, it is very likely that the virus recognizes other receptors/co-receptors besides the ACE2. The NTD of the SARS-CoV-2 contains a receptor-binding motif different from that of SARS-CoV, with some insertions that could confer to the new coronavirus new receptor binding abilities. In particular, motifs similar to the insertion 72GTNGTKR78 have been found in structural proteins of other viruses; and these motifs were located in putative regions involved in recognizing protein and sugar receptors, suggesting therefore that similar binding abilities could be displayed by the SARS-CoV-2 S1-NTD. Moreover, concerning the origin of these NTD insertions, our findings point towards an evolutionary acquisition rather than the hypothesis of an engineered virus.

Authors+Show Affiliations

College of Basic Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China.Department of Gastroenterology, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu Province, China.Department of Gastroenterology, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu Province, China. Electronic address: ruihuashi@126.com.College of Basic Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China. Electronic address: jihongmeng@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32531235

Citation

Behloul, Nouredine, et al. "Role of the GTNGTKR Motif in the N-terminal Receptor-binding Domain of the SARS-CoV-2 Spike Protein." Virus Research, vol. 286, 2020, p. 198058.
Behloul N, Baha S, Shi R, et al. Role of the GTNGTKR motif in the N-terminal receptor-binding domain of the SARS-CoV-2 spike protein. Virus Res. 2020;286:198058.
Behloul, N., Baha, S., Shi, R., & Meng, J. (2020). Role of the GTNGTKR motif in the N-terminal receptor-binding domain of the SARS-CoV-2 spike protein. Virus Research, 286, 198058. https://doi.org/10.1016/j.virusres.2020.198058
Behloul N, et al. Role of the GTNGTKR Motif in the N-terminal Receptor-binding Domain of the SARS-CoV-2 Spike Protein. Virus Res. 2020;286:198058. PubMed PMID: 32531235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of the GTNGTKR motif in the N-terminal receptor-binding domain of the SARS-CoV-2 spike protein. AU - Behloul,Nouredine, AU - Baha,Sarra, AU - Shi,Ruihua, AU - Meng,Jihong, Y1 - 2020/06/09/ PY - 2020/03/29/received PY - 2020/05/18/revised PY - 2020/06/07/accepted PY - 2020/6/13/pubmed PY - 2020/9/9/medline PY - 2020/6/13/entrez KW - COVID-19 KW - Coronavirus KW - Receptor binding-motif KW - Receptor-binding domain KW - SARS-CoV-2 SP - 198058 EP - 198058 JF - Virus research JO - Virus Res VL - 286 N2 - The 2019 novel coronavirus disease (COVID-19) that emerged in China has been declared as public health emergency of international concern by the World Health Organization and the causative pathogen was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this report, we analyzed the structural characteristics of the N-terminal domain of the S1 subunit (S1-NTD) of the SARS-CoV-2 spike protein in comparison to the SARS-CoV in particular, and to other viruses presenting similar characteristic in general. Given the severity and the wide and rapid spread of the SARS-CoV-2 infection, it is very likely that the virus recognizes other receptors/co-receptors besides the ACE2. The NTD of the SARS-CoV-2 contains a receptor-binding motif different from that of SARS-CoV, with some insertions that could confer to the new coronavirus new receptor binding abilities. In particular, motifs similar to the insertion 72GTNGTKR78 have been found in structural proteins of other viruses; and these motifs were located in putative regions involved in recognizing protein and sugar receptors, suggesting therefore that similar binding abilities could be displayed by the SARS-CoV-2 S1-NTD. Moreover, concerning the origin of these NTD insertions, our findings point towards an evolutionary acquisition rather than the hypothesis of an engineered virus. SN - 1872-7492 UR - https://www.unboundmedicine.com/medline/citation/32531235/Role_of_the_GTNGTKR_motif_in_the_N_terminal_receptor_binding_domain_of_the_SARS_CoV_2_spike_protein_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(20)30303-8 DB - PRIME DP - Unbound Medicine ER -