TY - JOUR T1 - [Effectiveness of corticoid pulses in patients with cytokine storm syndrome induced by SARS-CoV-2 infection]. AU - Callejas Rubio,José Luis, AU - Luna Del Castillo,Juan de Dios, AU - de la Hera Fernández,Javier, AU - Guirao Arrabal,Emilio, AU - Colmenero Ruiz,Manuel, AU - Ortego Centeno,Norberto, Y1 - 2020/05/27/ PY - 2020/04/10/received PY - 2020/04/18/revised PY - 2020/04/23/accepted PY - 2020/6/14/pubmed PY - 2020/8/28/medline PY - 2020/6/14/entrez KW - Coronavirus COVID-19 KW - Cytokine release synddrome KW - Hemofagocítico KW - Hemophagocytic KW - Síndrome de liberación de citocinas SP - 159 EP - 161 JF - Medicina clinica JO - Med Clin (Barc) VL - 155 IS - 4 N2 - INTRODUCTION: Cytokine storm syndrome (CSS) is a serious complication of COVID-19 patients. Treatment is tocilizumab. The use of glucocorticoids (GC) is controversial. In other very similar CSS, such as macrophage activation syndrome (MAS) and hemophagocytic syndrome (HFS), the main treatment are corticosteroids. Our objective is to evaluate the efficacy of GC in the CSS by COVID-19. PATIENTS: We included 92 patients with CSS associated to COVID-19 who received GC, GC, and tocilizumab and only tocilizumab. We determine CSS markers. We evaluated mortality, intubation, and a combined variable. RESULTS: In all cases the percentages of events were lower in the group of patients with GC was administered. The hazard ratio of the final variables with GC versus the group in which only tocilizumab was administered was lower as CGs were considered, with statistical significance for survival. DISCUSSION: The early use of GC pulses could control SLC, with a lower requirement to use tocilizumab and a decrease in events such as intubation and death. SN - 1578-8989 UR - https://www.unboundmedicine.com/medline/citation/32532461/[Effectiveness_of_corticoid_pulses_in_patients_with_cytokine_storm_syndrome_induced_by_SARS_CoV_2_infection]_ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0025-7753(20)30283-9 DB - PRIME DP - Unbound Medicine ER -