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Overview of lethal human coronaviruses.
Signal Transduct Target Ther. 2020 Jun 10; 5(1):89.ST

Abstract

Coronavirus infections of multiple origins have spread to date worldwide, causing severe respiratory diseases. Seven coronaviruses that infect humans have been identified: HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV, MERS-CoV, and SARS-CoV-2. Among them, SARS-CoV and MERS-CoV caused outbreaks in 2002 and 2012, respectively. SARS-CoV-2 (COVID-19) is the most recently discovered. It has created a severe worldwide outbreak beginning in late 2019, leading to date to over 4 million cases globally. Viruses are genetically simple, yet highly diverse. However, the recent outbreaks of SARS-CoV and MERS-CoV, and the ongoing outbreak of SARS-CoV-2, indicate that there remains a long way to go to identify and develop specific therapeutic treatments. Only after gaining a better understanding of their pathogenic mechanisms can we minimize viral pandemics. This paper mainly focuses on SARS-CoV, MERS-CoV, and SARS-CoV-2. Here, recent studies are summarized and reviewed, with a focus on virus-host interactions, vaccine-based and drug-targeted therapies, and the development of new approaches for clinical diagnosis and treatment.

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Authors+Show Affiliations

Chen B
Division of Respiratory and Critical Care Medicine, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, 610041, China.
Tian EK
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
He B
Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.
Tian L
Division of Respiratory and Critical Care Medicine, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, 610041, China.
Han R
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Wang S
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Xiang Q
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Zhang S
Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China. zhangs@wchscu.cn.
El Arnaout T
Kappa Crystals Ltd., Dublin, Ireland. Toufic.arnaout@kappacrystals.com.
Cheng W
Division of Respiratory and Critical Care Medicine, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, 610041, China. chengwei669@scu.edu.cn.

MeSH

Angiotensin-Converting Enzyme 2Antiviral AgentsBetacoronavirusCOVID-19Coronavirus InfectionsCytokinesGene Expression RegulationHost-Pathogen InteractionsHumansMiddle East Respiratory Syndrome CoronavirusMolecular Targeted TherapyPandemicsPeptidyl-Dipeptidase APneumonia, ViralSevere acute respiratory syndrome-related coronavirusSARS-CoV-2Severe Acute Respiratory SyndromeSignal TransductionSpike Glycoprotein, CoronavirusT-Lymphocytes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32533062

Citation

Chen, Bin, et al. "Overview of Lethal Human Coronaviruses." Signal Transduction and Targeted Therapy, vol. 5, no. 1, 2020, p. 89.
Chen B, Tian EK, He B, et al. Overview of lethal human coronaviruses. Signal Transduct Target Ther. 2020;5(1):89.
Chen, B., Tian, E. K., He, B., Tian, L., Han, R., Wang, S., Xiang, Q., Zhang, S., El Arnaout, T., & Cheng, W. (2020). Overview of lethal human coronaviruses. Signal Transduction and Targeted Therapy, 5(1), 89. https://doi.org/10.1038/s41392-020-0190-2
Chen B, et al. Overview of Lethal Human Coronaviruses. Signal Transduct Target Ther. 2020 Jun 10;5(1):89. PubMed PMID: 32533062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overview of lethal human coronaviruses. AU - Chen,Bin, AU - Tian,Er-Kang, AU - He,Bin, AU - Tian,Lejin, AU - Han,Ruiying, AU - Wang,Shuangwen, AU - Xiang,Qianrong, AU - Zhang,Shu, AU - El Arnaout,Toufic, AU - Cheng,Wei, Y1 - 2020/06/10/ PY - 2020/4/5/received PY - 2020/5/12/accepted PY - 2020/5/11/revised PY - 2020/6/14/entrez PY - 2020/6/14/pubmed PY - 2020/7/1/medline SP - 89 EP - 89 JF - Signal transduction and targeted therapy JO - Signal Transduct Target Ther VL - 5 IS - 1 N2 - Coronavirus infections of multiple origins have spread to date worldwide, causing severe respiratory diseases. Seven coronaviruses that infect humans have been identified: HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV, MERS-CoV, and SARS-CoV-2. Among them, SARS-CoV and MERS-CoV caused outbreaks in 2002 and 2012, respectively. SARS-CoV-2 (COVID-19) is the most recently discovered. It has created a severe worldwide outbreak beginning in late 2019, leading to date to over 4 million cases globally. Viruses are genetically simple, yet highly diverse. However, the recent outbreaks of SARS-CoV and MERS-CoV, and the ongoing outbreak of SARS-CoV-2, indicate that there remains a long way to go to identify and develop specific therapeutic treatments. Only after gaining a better understanding of their pathogenic mechanisms can we minimize viral pandemics. This paper mainly focuses on SARS-CoV, MERS-CoV, and SARS-CoV-2. Here, recent studies are summarized and reviewed, with a focus on virus-host interactions, vaccine-based and drug-targeted therapies, and the development of new approaches for clinical diagnosis and treatment. SN - 2059-3635 UR - https://www.unboundmedicine.com/medline/citation/32533062/Overview_of_lethal_human_coronaviruses_ DB - PRIME DP - Unbound Medicine ER -