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ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis.
Lipids Health Dis. 2020 Jun 13; 19(1):136.LH

Abstract

BACKGROUND

Diabetic nephropathy (DN) contributes to end-stage renal failure. Microvascular injury resulted from reactive oxygen species is implicated in the pathogenesis of DN. Genetic polymorphism of Apolipoprotein E (APOE) influences the antioxidative properties of the protein. The relationship of APOE polymorphism with the risks of nephropathy in type 2 diabetes (T2DN) remains elusive.

METHODS

An up-to-date meta-analysis was conducted on the basis of studies selected from PubMed, WanFang database, Embase, Vip database, Web of Science, Scopus, and CNKI database.

RESULTS

A total of 33 studies conferring 3266 cases and 3259 controls were selected on the basis of criteria of inclusion and exclusion in this meta-analysis. For APOE alleles, the pooled odds ratio (OR) of ε2 vs. ε3 was 1.89 (95% confidence intervals [95% CI]: 1.49-2.38, P < 0.0001). With regard to APOE genotypes, ε2/ε2, ε2/ε3, and ε2/ε4 increased the risk of T2DN (ε2/ε2 vs. ε3/ε3: OR = 2.32, 95% CI: 1.52-3.56, P = 0.0001; ε2/ε3 vs. ε3/ε3: OR = 1.97, 95% CI: 1.50-2.59, P<0.0001; ε2/ε4 vs. ε3/ε3: OR = 1.69, 95% CI: 1.18-2.44, P = 0.0046).

CONCLUSIONS

This meta-analysis found that the APOE ε2 allele and the ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) are the risk factors of T2DN.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, Jilin, China.Class of Clinical Medicine of English Teaching, Grade 2016, Ottawa-Shanghai Joint School of Medicine, Shanghai Jiao Tong University, Shanghai, 200023, China.Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, Jilin, China.Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, Jilin, China.Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, Jilin, China.Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, Jilin, China.Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, Jilin, China.Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, Jilin, China.Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, Jilin, China.Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, Jilin, China.Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, Jilin, China.Department of children & adolescence health, School of Public Health, Jilin University, Changchun, 130021, Jilin, China.Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, Jilin, China. ywliu@jlu.edu.cn.Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, 130021, Jilin, China. chengyi@jlu.edu.cn.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

32534589

Citation

Shi, Jikang, et al. "Ε2 Allele and Ε2-involved Genotypes (ε2/ε2, Ε2/ε3, and Ε2/ε4) May Confer the Association of APOE Genetic Polymorphism With Risks of Nephropathy in Type 2 Diabetes: a Meta-analysis." Lipids in Health and Disease, vol. 19, no. 1, 2020, p. 136.
Shi J, Cheng Z, Qiu S, et al. Ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis. Lipids Health Dis. 2020;19(1):136.
Shi, J., Cheng, Z., Qiu, S., Cui, H., Gu, Y., Zhao, Q., Ren, Y., Zhang, H., Sun, H., Liu, Y., Li, Y., Qiao, Y., Hu, Y., Liu, Y., & Cheng, Y. (2020). Ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis. Lipids in Health and Disease, 19(1), 136. https://doi.org/10.1186/s12944-020-01307-6
Shi J, et al. Ε2 Allele and Ε2-involved Genotypes (ε2/ε2, Ε2/ε3, and Ε2/ε4) May Confer the Association of APOE Genetic Polymorphism With Risks of Nephropathy in Type 2 Diabetes: a Meta-analysis. Lipids Health Dis. 2020 Jun 13;19(1):136. PubMed PMID: 32534589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis. AU - Shi,Jikang, AU - Cheng,Zhaorui, AU - Qiu,Shuang, AU - Cui,Heran, AU - Gu,Yulu, AU - Zhao,Qian, AU - Ren,Yaxuan, AU - Zhang,He, AU - Sun,Helin, AU - Liu,Yunkai, AU - Li,Yong, AU - Qiao,Yichun, AU - Hu,Yueyang, AU - Liu,Yawen, AU - Cheng,Yi, Y1 - 2020/06/13/ PY - 2019/10/05/received PY - 2020/06/02/accepted PY - 2020/6/15/entrez PY - 2020/6/15/pubmed PY - 2021/4/20/medline KW - Apolipoprotein E KW - Association KW - Diabetic nephropathy KW - Polymorphism KW - Risk KW - Type 2 diabetes SP - 136 EP - 136 JF - Lipids in health and disease JO - Lipids Health Dis VL - 19 IS - 1 N2 - BACKGROUND: Diabetic nephropathy (DN) contributes to end-stage renal failure. Microvascular injury resulted from reactive oxygen species is implicated in the pathogenesis of DN. Genetic polymorphism of Apolipoprotein E (APOE) influences the antioxidative properties of the protein. The relationship of APOE polymorphism with the risks of nephropathy in type 2 diabetes (T2DN) remains elusive. METHODS: An up-to-date meta-analysis was conducted on the basis of studies selected from PubMed, WanFang database, Embase, Vip database, Web of Science, Scopus, and CNKI database. RESULTS: A total of 33 studies conferring 3266 cases and 3259 controls were selected on the basis of criteria of inclusion and exclusion in this meta-analysis. For APOE alleles, the pooled odds ratio (OR) of ε2 vs. ε3 was 1.89 (95% confidence intervals [95% CI]: 1.49-2.38, P < 0.0001). With regard to APOE genotypes, ε2/ε2, ε2/ε3, and ε2/ε4 increased the risk of T2DN (ε2/ε2 vs. ε3/ε3: OR = 2.32, 95% CI: 1.52-3.56, P = 0.0001; ε2/ε3 vs. ε3/ε3: OR = 1.97, 95% CI: 1.50-2.59, P<0.0001; ε2/ε4 vs. ε3/ε3: OR = 1.69, 95% CI: 1.18-2.44, P = 0.0046). CONCLUSIONS: This meta-analysis found that the APOE ε2 allele and the ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) are the risk factors of T2DN. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/32534589/��2_allele_and_��2_involved_genotypes__��2/��2_��2/��3_and_��2/��4__may_confer_the_association_of_APOE_genetic_polymorphism_with_risks_of_nephropathy_in_type_2_diabetes:_a_meta_analysis_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01307-6 DB - PRIME DP - Unbound Medicine ER -