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Maternal exposure to ambient particulate matter 10 μm or less in diameter before and after pregnancy, and anencephaly risk: A population-based case-control study in China.
Environ Res. 2020 Jun 03; 188:109757.ER

Abstract

BACKGROUND

There is no epidemiological evidence on the effects of maternal exposure to ambient particulate matter 10 μm or less in diameter (PM10) and anencephaly risk in offspring.

METHODS

We conducted a population-based case-control study in Liaoning Province, China. The case group consisted of 663 cases with anencephaly and the control group consisted of 7950 healthy infants from the Maternal and Child Health Certificate Registry of Liaoning Province that were born between 2010 and 2015. Daily PM10 concentrations were obtained from 77 monitoring stations located within the study area. A multivariable logistic regression model was established to calculate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS

Maternal PM10 exposure was significantly associated with an increased risk of anencephaly at three months before conception (highest versus lowest tertile: OR = 1.74, 95% CI: 1.29-2.34; per 10 μg/m3 increment: OR = 1.13, 95% CI: 1.06-1.20) and three months after conception (highest versus lowest tertile: OR = 1.93, 95% CI: 1.44-2.60; per 10 μg/m3 increment: OR = 1.01, 95% CI: 0.95-1.08). The evaluation of shorter exposure windows revealed similar associations for PM10 exposure from the third month before pregnancy to the third month after pregnancy.

CONCLUSIONS

Maternal PM10 exposure is positively associated with anencephaly risk during the critical period of neural system development.

Authors+Show Affiliations

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.Department of Ophthalmology, Shenyang Women's and Children's Hospital, Shenyang, China. Electronic address: yanhonghuang_sy@sina.com.Department of Science and Education, Shenyang Maternity and Child Health Hospital, Shenyang, China.Department of Atmospheric Environment Monitoring, Liaoning Eco-environmental Monitoring Center, China.Liaoning Women and Children's Health Hospital, Shenyang, China.Department of Children's Health Prevention, Shenyang Maternity and Child Health Hospital, Shenyang, China.School of Environmental and Chemical Engineering, Shenyang Ligong University, Shenyang, China.Department of Atmospheric Environment Monitoring, Liaoning Eco-environmental Monitoring Center, China.Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address: wangj1@sj-hospital.org.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32535358

Citation

Xia, Jing, et al. "Maternal Exposure to Ambient Particulate Matter 10 Μm or Less in Diameter Before and After Pregnancy, and Anencephaly Risk: a Population-based Case-control Study in China." Environmental Research, vol. 188, 2020, p. 109757.
Xia J, Huang YH, Li J, et al. Maternal exposure to ambient particulate matter 10 μm or less in diameter before and after pregnancy, and anencephaly risk: A population-based case-control study in China. Environ Res. 2020;188:109757.
Xia, J., Huang, Y. H., Li, J., Liu, S., Chen, Y. L., Li, L. L., Jiang, C. Z., Chen, Z. J., Wang, Y., Liu, X. M., Wang, X. M., & Wang, J. (2020). Maternal exposure to ambient particulate matter 10 μm or less in diameter before and after pregnancy, and anencephaly risk: A population-based case-control study in China. Environmental Research, 188, 109757. https://doi.org/10.1016/j.envres.2020.109757
Xia J, et al. Maternal Exposure to Ambient Particulate Matter 10 Μm or Less in Diameter Before and After Pregnancy, and Anencephaly Risk: a Population-based Case-control Study in China. Environ Res. 2020 Jun 3;188:109757. PubMed PMID: 32535358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal exposure to ambient particulate matter 10 μm or less in diameter before and after pregnancy, and anencephaly risk: A population-based case-control study in China. AU - Xia,Jing, AU - Huang,Yan-Hong, AU - Li,Jing, AU - Liu,Shu, AU - Chen,Yan-Ling, AU - Li,Li-Li, AU - Jiang,Cheng-Zhi, AU - Chen,Zong-Jiao, AU - Wang,Ying, AU - Liu,Xue-Min, AU - Wang,Xiao-Ming, AU - Wang,Jun, Y1 - 2020/06/03/ PY - 2020/04/09/received PY - 2020/05/27/revised PY - 2020/05/27/accepted PY - 2020/6/15/pubmed PY - 2020/6/15/medline PY - 2020/6/15/entrez KW - Air pollution KW - Anencephaly KW - Case-control study KW - China KW - Pregnancy SP - 109757 EP - 109757 JF - Environmental research JO - Environ. Res. VL - 188 N2 - BACKGROUND: There is no epidemiological evidence on the effects of maternal exposure to ambient particulate matter 10 μm or less in diameter (PM10) and anencephaly risk in offspring. METHODS: We conducted a population-based case-control study in Liaoning Province, China. The case group consisted of 663 cases with anencephaly and the control group consisted of 7950 healthy infants from the Maternal and Child Health Certificate Registry of Liaoning Province that were born between 2010 and 2015. Daily PM10 concentrations were obtained from 77 monitoring stations located within the study area. A multivariable logistic regression model was established to calculate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Maternal PM10 exposure was significantly associated with an increased risk of anencephaly at three months before conception (highest versus lowest tertile: OR = 1.74, 95% CI: 1.29-2.34; per 10 μg/m3 increment: OR = 1.13, 95% CI: 1.06-1.20) and three months after conception (highest versus lowest tertile: OR = 1.93, 95% CI: 1.44-2.60; per 10 μg/m3 increment: OR = 1.01, 95% CI: 0.95-1.08). The evaluation of shorter exposure windows revealed similar associations for PM10 exposure from the third month before pregnancy to the third month after pregnancy. CONCLUSIONS: Maternal PM10 exposure is positively associated with anencephaly risk during the critical period of neural system development. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/32535358/Maternal_exposure_to_ambient_particulate_matter_10_μm_or_less_in_diameter_before_and_after_pregnancy,_and_anencephaly_risk:_A_population-based_case-control_study_in_China L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(20)30650-2 DB - PRIME DP - Unbound Medicine ER -
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