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Infrequent Monitoring of the Effects of Valproate and Carbamazepine Therapy in Patients With Epilepsy in Nigeria.
J Cent Nerv Syst Dis. 2020; 12:1179573520925934.JC

Abstract

Background

Carbamazepine and valproate are widely used in the treatment of epileptic seizures. However, these agents exhibit certain adverse effects including hematopoietic disorders (carbamazepine) and severe hepatotoxicity (valproate).

Purpose

To determine the extent of monitoring of the hematologic effects of carbamazepine as well as the extent of monitoring of the hepatic effects of valproate in patients with epilepsy receiving treatment with these agents.

Method

A cross-sectional antiepileptic drug use study using case notes of patients with epilepsy managed at the neurologic clinics of 2 tertiary medical facilities in Nigeria between January and December 2017.

Results

Carbamazepine was the most frequently prescribed antiepileptic drug (48.24%), followed by valproate (29.34%) and levetiracetam (9.24%). Pretreatment monitoring of hematologic effect was carried out in only 61.11% of patients placed on carbamazepine therapy while follow-up monitoring was done in 3.7% of these patients. Also, in patients placed on valproate therapy, pretreatment and follow-up monitoring of the hepatic effect was done in only 33.71% and 19.0% of the patients, respectively.

Conclusions

The extent of monitoring of the hematologic effects of carbamazepine, as well as the hepatic effects of valproate in the cohort studied, is poor.

Authors+Show Affiliations

Department of Clinical Pharmacy and Biopharmacy, University of Uyo, Uyo, Nigeria.Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Nigeria.Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Nigeria.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32536783

Citation

Eshiet, Unyime Israel, et al. "Infrequent Monitoring of the Effects of Valproate and Carbamazepine Therapy in Patients With Epilepsy in Nigeria." Journal of Central Nervous System Disease, vol. 12, 2020, p. 1179573520925934.
Eshiet UI, Ubaka CM, Ukwe CV. Infrequent Monitoring of the Effects of Valproate and Carbamazepine Therapy in Patients With Epilepsy in Nigeria. J Cent Nerv Syst Dis. 2020;12:1179573520925934.
Eshiet, U. I., Ubaka, C. M., & Ukwe, C. V. (2020). Infrequent Monitoring of the Effects of Valproate and Carbamazepine Therapy in Patients With Epilepsy in Nigeria. Journal of Central Nervous System Disease, 12, 1179573520925934. https://doi.org/10.1177/1179573520925934
Eshiet UI, Ubaka CM, Ukwe CV. Infrequent Monitoring of the Effects of Valproate and Carbamazepine Therapy in Patients With Epilepsy in Nigeria. J Cent Nerv Syst Dis. 2020;12:1179573520925934. PubMed PMID: 32536783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infrequent Monitoring of the Effects of Valproate and Carbamazepine Therapy in Patients With Epilepsy in Nigeria. AU - Eshiet,Unyime Israel, AU - Ubaka,Chukwuemeka Michael, AU - Ukwe,Chinwe Victoria, Y1 - 2020/06/01/ PY - 2019/12/12/received PY - 2020/04/17/accepted PY - 2020/6/16/entrez PY - 2020/6/17/pubmed PY - 2020/6/17/medline KW - Monitoring KW - effect KW - follow-up KW - pretreatment SP - 1179573520925934 EP - 1179573520925934 JF - Journal of central nervous system disease JO - J Cent Nerv Syst Dis VL - 12 N2 - Background: Carbamazepine and valproate are widely used in the treatment of epileptic seizures. However, these agents exhibit certain adverse effects including hematopoietic disorders (carbamazepine) and severe hepatotoxicity (valproate). Purpose: To determine the extent of monitoring of the hematologic effects of carbamazepine as well as the extent of monitoring of the hepatic effects of valproate in patients with epilepsy receiving treatment with these agents. Method: A cross-sectional antiepileptic drug use study using case notes of patients with epilepsy managed at the neurologic clinics of 2 tertiary medical facilities in Nigeria between January and December 2017. Results: Carbamazepine was the most frequently prescribed antiepileptic drug (48.24%), followed by valproate (29.34%) and levetiracetam (9.24%). Pretreatment monitoring of hematologic effect was carried out in only 61.11% of patients placed on carbamazepine therapy while follow-up monitoring was done in 3.7% of these patients. Also, in patients placed on valproate therapy, pretreatment and follow-up monitoring of the hepatic effect was done in only 33.71% and 19.0% of the patients, respectively. Conclusions: The extent of monitoring of the hematologic effects of carbamazepine, as well as the hepatic effects of valproate in the cohort studied, is poor. SN - 1179-5735 UR - https://www.unboundmedicine.com/medline/citation/32536783/Infrequent_Monitoring_of_the_Effects_of_Valproate_and_Carbamazepine_Therapy_in_Patients_With_Epilepsy_in_Nigeria L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32536783/ DB - PRIME DP - Unbound Medicine ER -
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