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Oxaliplatin-induced peripheral neuropathy risk factors and management in Tunisian population.
Pan Afr Med J. 2020; 35:83.PA

Abstract

The most important limits of oxaliplatin treatment is its peripheral neurotoxicity. The aim of our study was to evaluate the oxaliplatin-induced peripheral neuropathy, its impact on treatment and its management. One hundred chemo-naive patients treated with oxaliplatin-based regimen in the medical oncology department of the military hospital of Tunis between 2012 and 2017 were recruited retrospectively. Evaluation of neuropathy was done according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE V4). Fifty-six patients were aged more than 60 years. The sex-ratio was 1.56. Twenty-seven patients were overweight, 17 were obese and 56 had a BMI inferior to 25 kg/m2. Two patients were consuming alcohol. Twenty-three patients had diabetes. Sixty-four patients developed chronic peripheral neuropathy because of oxaliplatin (grade 1-2 in 58 cases and grade 3 in 6 cases). Sex, BMI, diabetes and alcohol consumption were not associated with the development of peripheral neuropathy. No association was found between grades of neuropathy and sex, alcohol consumption and diabetes. The median cumulative dose of oxaliplatin that induced neuropathy was 432.4 mg/m2. The most prescribed treatment was gabapentin (81%) and carbamazepine (16.8%). The treatment was not sufficient to stop neuropathy in 82.6% of cases. Dose reduction was done in 64.2% of cases, treatment delay in 10.7% of cases and treatment interruption in 10.7% of cases. We didn't find any association between known risk factors and peripheral neuropathy. The cumulative dose is interesting to define or to predict the timing of neurotoxicity.

Authors+Show Affiliations

Faculté de Médecine de Tunis, Department of Medical Oncology, The Military Hospital of Tunis, Universiy of Tunis El Manar, Montfleury, Tunis, Tunisia.Faculté de Médecine de Tunis, Department of Medical Oncology, The Military Hospital of Tunis, Universiy of Tunis El Manar, Montfleury, Tunis, Tunisia.Faculté de Médecine de Tunis, Department of Medical Oncology, The Military Hospital of Tunis, Universiy of Tunis El Manar, Montfleury, Tunis, Tunisia.Faculté de Médecine de Tunis, Department of Medical Oncology, The Military Hospital of Tunis, Universiy of Tunis El Manar, Montfleury, Tunis, Tunisia.Faculté de Médecine de Tunis, Department of Medical Oncology, The Military Hospital of Tunis, Universiy of Tunis El Manar, Montfleury, Tunis, Tunisia.Faculté de Médecine de Tunis, Department of Medical Oncology, The Military Hospital of Tunis, Universiy of Tunis El Manar, Montfleury, Tunis, Tunisia.Faculté de Médecine de Tunis, Department of Medical Oncology, The Military Hospital of Tunis, Universiy of Tunis El Manar, Montfleury, Tunis, Tunisia.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32537086

Citation

Zribi, Aref, et al. "Oxaliplatin-induced Peripheral Neuropathy Risk Factors and Management in Tunisian Population." The Pan African Medical Journal, vol. 35, 2020, p. 83.
Zribi A, Nasr SB, Hamdi S, et al. Oxaliplatin-induced peripheral neuropathy risk factors and management in Tunisian population. Pan Afr Med J. 2020;35:83.
Zribi, A., Nasr, S. B., Hamdi, S., Ayari, J., Fendri, S., Balti, M., & Haddaoui, A. (2020). Oxaliplatin-induced peripheral neuropathy risk factors and management in Tunisian population. The Pan African Medical Journal, 35, 83. https://doi.org/10.11604/pamj.2020.35.83.18357
Zribi A, et al. Oxaliplatin-induced Peripheral Neuropathy Risk Factors and Management in Tunisian Population. Pan Afr Med J. 2020;35:83. PubMed PMID: 32537086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxaliplatin-induced peripheral neuropathy risk factors and management in Tunisian population. AU - Zribi,Aref, AU - Nasr,Sonia Ben, AU - Hamdi,Syrine, AU - Ayari,Jihen, AU - Fendri,Sana, AU - Balti,Mehdi, AU - Haddaoui,Abderrazek, Y1 - 2020/03/19/ PY - 2019/02/05/received PY - 2020/02/11/accepted PY - 2020/6/16/entrez KW - Chemotherapy KW - neuropathy KW - oxaliplatin KW - toxicity SP - 83 EP - 83 JF - The Pan African medical journal JO - Pan Afr Med J VL - 35 N2 - The most important limits of oxaliplatin treatment is its peripheral neurotoxicity. The aim of our study was to evaluate the oxaliplatin-induced peripheral neuropathy, its impact on treatment and its management. One hundred chemo-naive patients treated with oxaliplatin-based regimen in the medical oncology department of the military hospital of Tunis between 2012 and 2017 were recruited retrospectively. Evaluation of neuropathy was done according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE V4). Fifty-six patients were aged more than 60 years. The sex-ratio was 1.56. Twenty-seven patients were overweight, 17 were obese and 56 had a BMI inferior to 25 kg/m2. Two patients were consuming alcohol. Twenty-three patients had diabetes. Sixty-four patients developed chronic peripheral neuropathy because of oxaliplatin (grade 1-2 in 58 cases and grade 3 in 6 cases). Sex, BMI, diabetes and alcohol consumption were not associated with the development of peripheral neuropathy. No association was found between grades of neuropathy and sex, alcohol consumption and diabetes. The median cumulative dose of oxaliplatin that induced neuropathy was 432.4 mg/m2. The most prescribed treatment was gabapentin (81%) and carbamazepine (16.8%). The treatment was not sufficient to stop neuropathy in 82.6% of cases. Dose reduction was done in 64.2% of cases, treatment delay in 10.7% of cases and treatment interruption in 10.7% of cases. We didn't find any association between known risk factors and peripheral neuropathy. The cumulative dose is interesting to define or to predict the timing of neurotoxicity. SN - 1937-8688 UR - https://www.unboundmedicine.com/medline/citation/32537086/Oxaliplatin-induced_peripheral_neuropathy_risk_factors_and_management_in_Tunisian_population L2 - https://www.panafrican-med-journal.com/content/article/35/83/full/ DB - PRIME DP - Unbound Medicine ER -
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