Tags

Type your tag names separated by a space and hit enter

Extramedullary disease in acute promyelocytic leukaemia: A rare presentation.
SAGE Open Med Case Rep. 2020; 8:2050313X20926076.SO

Abstract

Acute promyelocytic leukaemia consists of 7%-8% of cases of acute myeloid leukaemia. Extramedullary manifestations are rare and show distinct biological features. We describe a 22-year-old female of Malay ethnicity who presented with fever and a left axillary swelling for a week. The peripheral blood smear showed abnormal promyelocytes with faggot cells. PML-RAR-alpha t(15;17) (q22; q12) was detected by polymerase chain reaction. The left axillary swelling histology and immunohistochemical staining confirmed granulocytic sarcoma. She was induced with triple agents consisting of all-trans-retinoic-acid, arsenic trioxide and idarubicin. On day 14 of induction, she developed severe neutropenic sepsis in which she responded to ventilation and antimicrobials. She completed her induction, consolidation and maintenance therapy. Currently she is in molecular and morphological remission. Extramedullary disease in acute promyelocytic leukaemia usually has a severe clinical presentation. Granulocytic sarcoma may present as an early feature of acute promyelocytic leukaemia.

Authors+Show Affiliations

Department of Hematology, Ampang Hospital, Ampang, Malaysia.Department of Hematology, Ampang Hospital, Ampang, Malaysia.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32537161

Citation

Kasinathan, Ganesh, and Jameela Sathar. "Extramedullary Disease in Acute Promyelocytic Leukaemia: a Rare Presentation." SAGE Open Medical Case Reports, vol. 8, 2020, p. 2050313X20926076.
Kasinathan G, Sathar J. Extramedullary disease in acute promyelocytic leukaemia: A rare presentation. SAGE Open Med Case Rep. 2020;8:2050313X20926076.
Kasinathan, G., & Sathar, J. (2020). Extramedullary disease in acute promyelocytic leukaemia: A rare presentation. SAGE Open Medical Case Reports, 8, 2050313X20926076. https://doi.org/10.1177/2050313X20926076
Kasinathan G, Sathar J. Extramedullary Disease in Acute Promyelocytic Leukaemia: a Rare Presentation. SAGE Open Med Case Rep. 2020;8:2050313X20926076. PubMed PMID: 32537161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extramedullary disease in acute promyelocytic leukaemia: A rare presentation. AU - Kasinathan,Ganesh, AU - Sathar,Jameela, Y1 - 2020/06/02/ PY - 2019/10/05/received PY - 2020/04/17/accepted PY - 2020/6/16/entrez PY - 2020/6/17/pubmed PY - 2020/6/17/medline KW - Acute promyelocytic leukaemia KW - arsenic trioxide KW - faggot cells KW - granulocytic sarcoma SP - 2050313X20926076 EP - 2050313X20926076 JF - SAGE open medical case reports JO - SAGE Open Med Case Rep VL - 8 N2 - Acute promyelocytic leukaemia consists of 7%-8% of cases of acute myeloid leukaemia. Extramedullary manifestations are rare and show distinct biological features. We describe a 22-year-old female of Malay ethnicity who presented with fever and a left axillary swelling for a week. The peripheral blood smear showed abnormal promyelocytes with faggot cells. PML-RAR-alpha t(15;17) (q22; q12) was detected by polymerase chain reaction. The left axillary swelling histology and immunohistochemical staining confirmed granulocytic sarcoma. She was induced with triple agents consisting of all-trans-retinoic-acid, arsenic trioxide and idarubicin. On day 14 of induction, she developed severe neutropenic sepsis in which she responded to ventilation and antimicrobials. She completed her induction, consolidation and maintenance therapy. Currently she is in molecular and morphological remission. Extramedullary disease in acute promyelocytic leukaemia usually has a severe clinical presentation. Granulocytic sarcoma may present as an early feature of acute promyelocytic leukaemia. SN - 2050-313X UR - https://www.unboundmedicine.com/medline/citation/32537161/Extramedullary_disease_in_acute_promyelocytic_leukaemia:_A_rare_presentation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32537161/ DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.