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Clinical and radiological features of novel coronavirus pneumonia.
J Xray Sci Technol. 2020; 28(3):391-404.JX

Abstract

Recently, COVID-19 has spread in more than 100 countries and regions around the world, raising grave global concerns. COVID-19 transmits mainly through respiratory droplets and close contacts, causing cluster infections. The symptoms are dominantly fever, fatigue, and dry cough, and can be complicated with tiredness, sore throat, and headache. A few patients have symptoms such as stuffy nose, runny nose, and diarrhea. The severe disease can progress rapidly into the acute respiratory distress syndrome (ARDS). Reverse transcription polymerase chain reaction (RT-PCR) and Next-generation sequencing (NGS) are the gold standard for diagnosing COVID-19. Chest imaging is used for cross validation. Chest CT is highly recommended as the preferred imaging diagnosis method for COVID-19 due to its high density and high spatial resolution. The common CT manifestation of COVID-19 includes multiple segmental ground glass opacities (GGOs) distributed dominantly in extrapulmonary/subpleural zones and along bronchovascular bundles with crazy paving sign and interlobular septal thickening and consolidation. Pleural effusion or mediastinal lymphadenopathy is rarely seen. In CT imaging, COVID-19 manifests differently in its various stages including the early stage, the progression (consolidation) stage, and the absorption stage. In its early stage, it manifests as scattered flaky GGOs in various sizes, dominated by peripheral pulmonary zone/subpleural distributions. In the progression state, GGOs increase in number and/or size, and lung consolidations may become visible. The main manifestation in the absorption stage is interstitial change of both lungs, such as fibrous cords and reticular opacities. Differentiation between COVID-19 pneumonia and other viral pneumonias are also analyzed. Thus, CT examination can help reduce false negatives of nucleic acid tests.

Authors+Show Affiliations

Department of Medical Imaging, Shenzhen Center for Chronic Disease Control, Guangdong Shenzhen 518020, China.Department of Medical Imaging, The Fourth People's Hospital of Nanning, Guangxi Nanning 530023, China.MS Technologies, 10110 Molecular Dr., Suite 305, Rockville, MD 20850, USA. Shenzhen Zhiying Medical Co., Ltd, Guangdong Shenzhen 518020, China.National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA.Department of Medical Imaging, Shenzhen Center for Chronic Disease Control, Guangdong Shenzhen 518020, China.

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Review

Language

eng

PubMed ID

32538893

Citation

Zheng, Qiuting, et al. "Clinical and Radiological Features of Novel Coronavirus Pneumonia." Journal of X-ray Science and Technology, vol. 28, no. 3, 2020, pp. 391-404.
Zheng Q, Lu Y, Lure F, et al. Clinical and radiological features of novel coronavirus pneumonia. J Xray Sci Technol. 2020;28(3):391-404.
Zheng, Q., Lu, Y., Lure, F., Jaeger, S., & Lu, P. (2020). Clinical and radiological features of novel coronavirus pneumonia. Journal of X-ray Science and Technology, 28(3), 391-404. https://doi.org/10.3233/XST-200687
Zheng Q, et al. Clinical and Radiological Features of Novel Coronavirus Pneumonia. J Xray Sci Technol. 2020;28(3):391-404. PubMed PMID: 32538893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and radiological features of novel coronavirus pneumonia. AU - Zheng,Qiuting, AU - Lu,Yibo, AU - Lure,Fleming, AU - Jaeger,Stefan, AU - Lu,Puxuan, PY - 2020/6/17/pubmed PY - 2020/7/10/medline PY - 2020/6/16/entrez KW - 2019-novel Coronaviruses (2019-nCoV) KW - COVID-19 KW - Computed Tomography (CT) KW - SARS-CoV-2 KW - differentiation of pneumonia KW - ground glass opacity (GGO) SP - 391 EP - 404 JF - Journal of X-ray science and technology JO - J Xray Sci Technol VL - 28 IS - 3 N2 - Recently, COVID-19 has spread in more than 100 countries and regions around the world, raising grave global concerns. COVID-19 transmits mainly through respiratory droplets and close contacts, causing cluster infections. The symptoms are dominantly fever, fatigue, and dry cough, and can be complicated with tiredness, sore throat, and headache. A few patients have symptoms such as stuffy nose, runny nose, and diarrhea. The severe disease can progress rapidly into the acute respiratory distress syndrome (ARDS). Reverse transcription polymerase chain reaction (RT-PCR) and Next-generation sequencing (NGS) are the gold standard for diagnosing COVID-19. Chest imaging is used for cross validation. Chest CT is highly recommended as the preferred imaging diagnosis method for COVID-19 due to its high density and high spatial resolution. The common CT manifestation of COVID-19 includes multiple segmental ground glass opacities (GGOs) distributed dominantly in extrapulmonary/subpleural zones and along bronchovascular bundles with crazy paving sign and interlobular septal thickening and consolidation. Pleural effusion or mediastinal lymphadenopathy is rarely seen. In CT imaging, COVID-19 manifests differently in its various stages including the early stage, the progression (consolidation) stage, and the absorption stage. In its early stage, it manifests as scattered flaky GGOs in various sizes, dominated by peripheral pulmonary zone/subpleural distributions. In the progression state, GGOs increase in number and/or size, and lung consolidations may become visible. The main manifestation in the absorption stage is interstitial change of both lungs, such as fibrous cords and reticular opacities. Differentiation between COVID-19 pneumonia and other viral pneumonias are also analyzed. Thus, CT examination can help reduce false negatives of nucleic acid tests. SN - 1095-9114 UR - https://www.unboundmedicine.com/medline/citation/32538893/Clinical_and_radiological_features_of_novel_coronavirus_pneumonia_ DB - PRIME DP - Unbound Medicine ER -