Citation
Rogers, Thomas F., et al. "Isolation of Potent SARS-CoV-2 Neutralizing Antibodies and Protection From Disease in a Small Animal Model." Science (New York, N.Y.), vol. 369, no. 6506, 2020, pp. 956-963.
Rogers TF, Zhao F, Huang D, et al. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science. 2020;369(6506):956-963.
Rogers, T. F., Zhao, F., Huang, D., Beutler, N., Burns, A., He, W. T., Limbo, O., Smith, C., Song, G., Woehl, J., Yang, L., Abbott, R. K., Callaghan, S., Garcia, E., Hurtado, J., Parren, M., Peng, L., Ramirez, S., Ricketts, J., ... Burton, D. R. (2020). Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science (New York, N.Y.), 369(6506), 956-963. https://doi.org/10.1126/science.abc7520
Rogers TF, et al. Isolation of Potent SARS-CoV-2 Neutralizing Antibodies and Protection From Disease in a Small Animal Model. Science. 2020 08 21;369(6506):956-963. PubMed PMID: 32540903.
TY - JOUR
T1 - Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model.
AU - Rogers,Thomas F,
AU - Zhao,Fangzhu,
AU - Huang,Deli,
AU - Beutler,Nathan,
AU - Burns,Alison,
AU - He,Wan-Ting,
AU - Limbo,Oliver,
AU - Smith,Chloe,
AU - Song,Ge,
AU - Woehl,Jordan,
AU - Yang,Linlin,
AU - Abbott,Robert K,
AU - Callaghan,Sean,
AU - Garcia,Elijah,
AU - Hurtado,Jonathan,
AU - Parren,Mara,
AU - Peng,Linghang,
AU - Ramirez,Sydney,
AU - Ricketts,James,
AU - Ricciardi,Michael J,
AU - Rawlings,Stephen A,
AU - Wu,Nicholas C,
AU - Yuan,Meng,
AU - Smith,Davey M,
AU - Nemazee,David,
AU - Teijaro,John R,
AU - Voss,James E,
AU - Wilson,Ian A,
AU - Andrabi,Raiees,
AU - Briney,Bryan,
AU - Landais,Elise,
AU - Sok,Devin,
AU - Jardine,Joseph G,
AU - Burton,Dennis R,
Y1 - 2020/06/15/
PY - 2020/05/12/received
PY - 2020/06/11/accepted
PY - 2020/6/17/pubmed
PY - 2020/9/2/medline
PY - 2020/6/17/entrez
SP - 956
EP - 963
JF - Science (New York, N.Y.)
JO - Science
VL - 369
IS - 6506
N2 - Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-recovered participants, developed neutralization assays to investigate antibody responses, adapted our high-throughput antibody generation pipeline to rapidly screen more than 1800 antibodies, and established an animal model to test protection. We isolated potent neutralizing antibodies (nAbs) to two epitopes on the receptor binding domain (RBD) and to distinct non-RBD epitopes on the spike (S) protein. As indicated by maintained weight and low lung viral titers in treated animals, the passive transfer of a nAb provides protection against disease in high-dose SARS-CoV-2 challenge in Syrian hamsters. The study suggests a role for nAbs in prophylaxis, and potentially therapy, of COVID-19. The nAbs also define protective epitopes to guide vaccine design.
SN - 1095-9203
UR - https://www.unboundmedicine.com/medline/citation/32540903/Isolation_of_potent_SARS_CoV_2_neutralizing_antibodies_and_protection_from_disease_in_a_small_animal_model_
DB - PRIME
DP - Unbound Medicine
ER -