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Uterine leiomyomas: correlation between histologic composition and stiffness via magnetic resonance elastography - a Pilot Study.
Ginekol Pol. 2020 Jun 16 [Online ahead of print]GP

Abstract

OBJECTIVES

To evaluate magnetic resonance elastography as a tool for characterizing uterine leimyomas.

MATERIAL AND METHODS

At total of 12 women with symptomatic leiomyomas diagnosed in physical and ultrasound examinations were enrolled in this pilot study. Before surgery, all patients underwent magnetic resonance elastography of the uterus using a 1.5 T MR whole-body scanner (Optima, GE Healthcare, Milwaukee, WI, USA). Surgical specimens were forwarded for histological examination. The findings were allocated into 3 categories depending on the percentage content of connective tissue: below 15%, from 15 to 30% and more than 30%. The median stiffness of leiomyomas for each of the group was calculated. The U-Mann Whitney test was used for statistical analysis.

RESULTS

The stiffness of the leiomyomas ranged between 3.7-6.9 kPa (median value 4.9 kPa). The concentration of extracellular components in the leiomyomas did not exceed 40%. An increasing trend of the stiffness with the growing percentage of extracellular component was observed. Stiffness of the leiomyomas obtained by MRE varies depending on microscopic composition.

CONCLUSIONS

The value of stiffness shows a trend of increasing with the percentage of extracellular component of the leiomyoma. Further studies are required to assess the usefulness of MRE in diagnostics of uterine leiomyomas.

Authors+Show Affiliations

Department of Biophysics, Faculty of Mathematics and Natural Sciences, University of Rzeszow, Poland.Department of Obstetrics and Gynecology, Institute of Medical Sciences, Medical College, University of Rzeszow, Poland.Department of Clinical Pathomorphology, Provincial Clinical Hospital No 2 Rzeszow, Poland.Institute of Nuclear Physics Polish Academy of Sciences, Cracow, Poland. jakub.baran@ifj.edu.pl.Department of Biophysics, Faculty of Mathematics and Natural Sciences, University of Rzeszow, Poland.Department of Radiology, Mayo Clinic, USA.Department of Obstetrics and Gynecology, Institute of Medical Sciences, Medical College, University of Rzeszow, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32542642

Citation

Obrzut, Marzanna, et al. "Uterine Leiomyomas: Correlation Between Histologic Composition and Stiffness Via Magnetic Resonance Elastography - a Pilot Study." Ginekologia Polska, 2020.
Obrzut M, Obrzut B, Zmuda M, et al. Uterine leiomyomas: correlation between histologic composition and stiffness via magnetic resonance elastography - a Pilot Study. Ginekol Pol. 2020.
Obrzut, M., Obrzut, B., Zmuda, M., Baran, J., Cholewa, M., Ehman, R., & Darmochwal-Kolarz, D. (2020). Uterine leiomyomas: correlation between histologic composition and stiffness via magnetic resonance elastography - a Pilot Study. Ginekologia Polska. https://doi.org/10.5603/GP.a2020.0067
Obrzut M, et al. Uterine Leiomyomas: Correlation Between Histologic Composition and Stiffness Via Magnetic Resonance Elastography - a Pilot Study. Ginekol Pol. 2020 Jun 16; PubMed PMID: 32542642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uterine leiomyomas: correlation between histologic composition and stiffness via magnetic resonance elastography - a Pilot Study. AU - Obrzut,Marzanna, AU - Obrzut,Bogdan, AU - Zmuda,Marcin, AU - Baran,Jakub, AU - Cholewa,Marian, AU - Ehman,Richard, AU - Darmochwal-Kolarz,Dorota, Y1 - 2020/06/16/ PY - 2019/11/27/received PY - 2020/03/13/accepted PY - 2020/03/11/revised PY - 2020/6/17/entrez KW - histologic composition KW - leiomyoma KW - magnetic resonance elastography JF - Ginekologia polska JO - Ginekol. Pol. N2 - OBJECTIVES: To evaluate magnetic resonance elastography as a tool for characterizing uterine leimyomas. MATERIAL AND METHODS: At total of 12 women with symptomatic leiomyomas diagnosed in physical and ultrasound examinations were enrolled in this pilot study. Before surgery, all patients underwent magnetic resonance elastography of the uterus using a 1.5 T MR whole-body scanner (Optima, GE Healthcare, Milwaukee, WI, USA). Surgical specimens were forwarded for histological examination. The findings were allocated into 3 categories depending on the percentage content of connective tissue: below 15%, from 15 to 30% and more than 30%. The median stiffness of leiomyomas for each of the group was calculated. The U-Mann Whitney test was used for statistical analysis. RESULTS: The stiffness of the leiomyomas ranged between 3.7-6.9 kPa (median value 4.9 kPa). The concentration of extracellular components in the leiomyomas did not exceed 40%. An increasing trend of the stiffness with the growing percentage of extracellular component was observed. Stiffness of the leiomyomas obtained by MRE varies depending on microscopic composition. CONCLUSIONS: The value of stiffness shows a trend of increasing with the percentage of extracellular component of the leiomyoma. Further studies are required to assess the usefulness of MRE in diagnostics of uterine leiomyomas. SN - 2543-6767 UR - https://www.unboundmedicine.com/medline/citation/32542642/Uterine_leiomyomas:_correlation_between_histologic_composition_and_stiffness_via_magnetic_resonance_elastography_-_a_Pilot_Study L2 - http://dx.doi.org/10.5603/GP.a2020.0067 DB - PRIME DP - Unbound Medicine ER -
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