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COVID-19 and the Ocular Surface: A Review of Transmission and Manifestations.
Ocul Immunol Inflamm. 2020 Jul 03; 28(5):726-734.OI

Abstract

PURPOSE

The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has reached pandemic proportions within an unprecedented span of time. It is controversial whether the virus can be transmitted via tears and its ocular implications have not been widely studied. In this article, the current evidence related to ocular transmission and ocular manifestations is reviewed.

RESULTS

Several mechanisms for the ocular transmission of the virus are proposed with highlight on the nasolacrimal system as a conduit between the eye and the respiratory tract, and the role of the lacrimal gland in hematogenous spread. Ocular surface manifestations such as conjunctivitis are more commonly reported.

CONCLUSION

The exact pathophysiology of ocular transmission of the virus remains incompletely understood, although there is preliminary evidence of SARS-CoV-2 being detected in ocular secretions. The ocular tropism of the virus and its potential to cause localized ocular disease are worth considering.

Authors+Show Affiliations

Department of Ophthalmology, National Healthcare Group Eye Institute , Singapore, Singapore.Department of Ophthalmology, National Healthcare Group Eye Institute , Singapore, Singapore.Singapore Eye Research Institute , Singapore, Singapore. Department of Cornea and External Diseases, Singapore National Eye Centre , Singapore, Singapore. Department of Ophthalmology, Duke-NUS Medical School , Singapore, Singapore.Department of Ophthalmology, Post Graduate Institute of Medical Education and Research , Chandigarh, India.Department of Internal Medicine, Woodlands Health Campus , Singapore, Singapore.Department of Ophthalmology, National Healthcare Group Eye Institute , Singapore, Singapore. Singapore Eye Research Institute , Singapore, Singapore. Department of Ophthalmology, Duke-NUS Medical School , Singapore, Singapore. Department of Uveitis, Moorfields Eye Hospital NHS Foundation Trust , London, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32543262

Citation

Ho, Dawn, et al. "COVID-19 and the Ocular Surface: a Review of Transmission and Manifestations." Ocular Immunology and Inflammation, vol. 28, no. 5, 2020, pp. 726-734.
Ho D, Low R, Tong L, et al. COVID-19 and the Ocular Surface: A Review of Transmission and Manifestations. Ocul Immunol Inflamm. 2020;28(5):726-734.
Ho, D., Low, R., Tong, L., Gupta, V., Veeraraghavan, A., & Agrawal, R. (2020). COVID-19 and the Ocular Surface: A Review of Transmission and Manifestations. Ocular Immunology and Inflammation, 28(5), 726-734. https://doi.org/10.1080/09273948.2020.1772313
Ho D, et al. COVID-19 and the Ocular Surface: a Review of Transmission and Manifestations. Ocul Immunol Inflamm. 2020 Jul 3;28(5):726-734. PubMed PMID: 32543262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19 and the Ocular Surface: A Review of Transmission and Manifestations. AU - Ho,Dawn, AU - Low,Rebecca, AU - Tong,Louis, AU - Gupta,Vishali, AU - Veeraraghavan,Aravamudan, AU - Agrawal,Rupesh, Y1 - 2020/06/16/ PY - 2020/6/17/pubmed PY - 2020/8/7/medline PY - 2020/6/17/entrez KW - COVID-19 KW - conjunctivitis KW - ocular surface KW - sars CoV-2 SP - 726 EP - 734 JF - Ocular immunology and inflammation JO - Ocul Immunol Inflamm VL - 28 IS - 5 N2 - PURPOSE: The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has reached pandemic proportions within an unprecedented span of time. It is controversial whether the virus can be transmitted via tears and its ocular implications have not been widely studied. In this article, the current evidence related to ocular transmission and ocular manifestations is reviewed. RESULTS: Several mechanisms for the ocular transmission of the virus are proposed with highlight on the nasolacrimal system as a conduit between the eye and the respiratory tract, and the role of the lacrimal gland in hematogenous spread. Ocular surface manifestations such as conjunctivitis are more commonly reported. CONCLUSION: The exact pathophysiology of ocular transmission of the virus remains incompletely understood, although there is preliminary evidence of SARS-CoV-2 being detected in ocular secretions. The ocular tropism of the virus and its potential to cause localized ocular disease are worth considering. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/32543262/COVID_19_and_the_Ocular_Surface:_A_Review_of_Transmission_and_Manifestations_ L2 - https://www.tandfonline.com/doi/full/10.1080/09273948.2020.1772313 DB - PRIME DP - Unbound Medicine ER -