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On-site testing of sutured organs: An experimental set up to cyclically tighten sutures.
J Mech Behav Biomed Mater. 2020 Sep; 109:103803.JM

Abstract

A number of surgical practices are aimed to compensate for tissue relaxation or weakened/atrophied muscles by means of suture prostheses/thread lifts. The success rate of these procedures is often very good in the short term, while it is quite variable among subjects and techniques in the middle-long term. Middle-long term failures are mostly related to suture distraction, loosening or wear, coming from repeated loading cycles. In this work, an experimental device to perform ex vivo tests on prosthetic sutures has been set up. An equine laryngoplasty has been used as a benchmark, being representative of sutures aimed to compensate for atrophied muscles. The peculiarity of this experimental set up is that the suture is on-site and it has been tightened with known, repeated loads, which do not depend on thread deformation at different load levels. Preliminary tests have been performed applying over 3000 load cycles and finally a tensile test up to rupture. Force/displacement curves obtained with this experimental set up have been reported and parameters useful to classify the biomechanical performance of sutures versus time (mainly its creep behaviour), have been outlined. Results have outlined that the organ-suture system undergoes significant creep over 3000 cycles, and this should be taken into account in order to foresee its long-term behaviour; in addition, the suture anchorage to cartilage should be improved. The experimental set up can be used to perform on-site testing of sutures, taking into account the compliance and creep response at both suture anchorage ends, in order to compare different surgeries and different kinds of thread.

Authors+Show Affiliations

Department of Engineering, University of Perugia, Italy.Surgery and Radiodiagnostics, Department of Veterinary Medicine, University of Perugia, Italy.Polito(BIO)MedLab, Politecnico di Torino, Italy; DIMEAS, Politecnico di Torino, Italy.Polito(BIO)MedLab, Politecnico di Torino, Italy; DIMEAS, Politecnico di Torino, Italy.Polito(BIO)MedLab, Politecnico di Torino, Italy; DIMEAS, Politecnico di Torino, Italy.Department of Engineering, University of Perugia, Italy. Electronic address: elisabetta.zanetti@unipg.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32543391

Citation

Pascoletti, Giulia, et al. "On-site Testing of Sutured Organs: an Experimental Set Up to Cyclically Tighten Sutures." Journal of the Mechanical Behavior of Biomedical Materials, vol. 109, 2020, p. 103803.
Pascoletti G, Pressanto MC, Putame G, et al. On-site testing of sutured organs: An experimental set up to cyclically tighten sutures. J Mech Behav Biomed Mater. 2020;109:103803.
Pascoletti, G., Pressanto, M. C., Putame, G., Terzini, M., Audenino, A. L., & Zanetti, E. M. (2020). On-site testing of sutured organs: An experimental set up to cyclically tighten sutures. Journal of the Mechanical Behavior of Biomedical Materials, 109, 103803. https://doi.org/10.1016/j.jmbbm.2020.103803
Pascoletti G, et al. On-site Testing of Sutured Organs: an Experimental Set Up to Cyclically Tighten Sutures. J Mech Behav Biomed Mater. 2020;109:103803. PubMed PMID: 32543391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On-site testing of sutured organs: An experimental set up to cyclically tighten sutures. AU - Pascoletti,Giulia, AU - Pressanto,Maria Chiara, AU - Putame,Giovanni, AU - Terzini,Mara, AU - Audenino,Alberto L, AU - Zanetti,Elisabetta M, Y1 - 2020/05/01/ PY - 2020/02/10/received PY - 2020/04/11/revised PY - 2020/04/15/accepted PY - 2020/6/17/pubmed PY - 2020/6/17/medline PY - 2020/6/17/entrez KW - Creep KW - Distraction KW - Failure KW - Neuropathy KW - Suture testing KW - Tissue relaxation SP - 103803 EP - 103803 JF - Journal of the mechanical behavior of biomedical materials JO - J Mech Behav Biomed Mater VL - 109 N2 - A number of surgical practices are aimed to compensate for tissue relaxation or weakened/atrophied muscles by means of suture prostheses/thread lifts. The success rate of these procedures is often very good in the short term, while it is quite variable among subjects and techniques in the middle-long term. Middle-long term failures are mostly related to suture distraction, loosening or wear, coming from repeated loading cycles. In this work, an experimental device to perform ex vivo tests on prosthetic sutures has been set up. An equine laryngoplasty has been used as a benchmark, being representative of sutures aimed to compensate for atrophied muscles. The peculiarity of this experimental set up is that the suture is on-site and it has been tightened with known, repeated loads, which do not depend on thread deformation at different load levels. Preliminary tests have been performed applying over 3000 load cycles and finally a tensile test up to rupture. Force/displacement curves obtained with this experimental set up have been reported and parameters useful to classify the biomechanical performance of sutures versus time (mainly its creep behaviour), have been outlined. Results have outlined that the organ-suture system undergoes significant creep over 3000 cycles, and this should be taken into account in order to foresee its long-term behaviour; in addition, the suture anchorage to cartilage should be improved. The experimental set up can be used to perform on-site testing of sutures, taking into account the compliance and creep response at both suture anchorage ends, in order to compare different surgeries and different kinds of thread. SN - 1878-0180 UR - https://www.unboundmedicine.com/medline/citation/32543391/On-site_testing_of_sutured_organs:_An_experimental_set_up_to_cyclically_tighten_sutures L2 - https://linkinghub.elsevier.com/retrieve/pii/S1751-6161(20)30357-X DB - PRIME DP - Unbound Medicine ER -
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