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Chemotherapeutic Potential of Epimedium brevicornum Extract: The cGMP-Specific PDE5 Inhibitor as Anti-Infertility Agent Following Long-Term Administration of Tramadol in Male Rats.
Antibiotics (Basel). 2020 Jun 11; 9(6)A

Abstract

Epimedium brevicornum Maxim (EbM) is a well-known Chinese herb that has been widely used for the treatment of several diseases. The main purpose of this study is to examine the role of Epimedium brevicornum extract in certain andrological parameters in rats as a natural modulator for adverse viewpoints associated with chronic administration of tramadol (TAM). Fifty rats were categorized into five groups. Untreated rats were known as Group I, whereas rats in Groups II and III were administered 2.43 g/kg/day of E. brevicornum extract and 50 mg/kg/day of TAM for 130 consecutive days, respectively. Both of Groups IV and V were administered TAM for 65 successive days, followed by concomitant use of both drugs for another 65 days, with the E. brevicornum extract at doses of 0.81 and 2.43 g/kg/day, respectively. TAM showed an injurious effect on sperm attributes, serum hormones, tissue malondialdehyde, superoxide dismutase, and nitric oxide. Elevation of the apoptotic marker Bax and a reduction of Bcl2 were recorded. Histopathological abnormalities have been reported in rat testicles. Rats treated with E. brevicornum extract with TAM showed an improvement in all the parameters tested. It could be presumed that E. brevicornum extract plus TAM exhibits a promising effect on the enhancement of male anti-infertility effects.

Authors+Show Affiliations

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.Biochemistry Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.Physiology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.Botany and Microbiology Department, Faculty of Science, Alexandria University, Alexandria 21568, Egypt.National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho, Obihiro 080-8555, Hokkaido, Japan.Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Al Beheira, Egypt.Doping Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh 11495, Saudi Arabia.Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32545153

Citation

Abdelaziz, Ahmed S., et al. "Chemotherapeutic Potential of Epimedium Brevicornum Extract: the cGMP-Specific PDE5 Inhibitor as Anti-Infertility Agent Following Long-Term Administration of Tramadol in Male Rats." Antibiotics (Basel, Switzerland), vol. 9, no. 6, 2020.
Abdelaziz AS, Kamel MA, Ahmed AI, et al. Chemotherapeutic Potential of Epimedium brevicornum Extract: The cGMP-Specific PDE5 Inhibitor as Anti-Infertility Agent Following Long-Term Administration of Tramadol in Male Rats. Antibiotics (Basel). 2020;9(6).
Abdelaziz, A. S., Kamel, M. A., Ahmed, A. I., Shalaby, S. I., El-Darier, S. M., Magdy Beshbishy, A., Batiha, G. E., Alomar, S. Y., & Khodeer, D. M. (2020). Chemotherapeutic Potential of Epimedium brevicornum Extract: The cGMP-Specific PDE5 Inhibitor as Anti-Infertility Agent Following Long-Term Administration of Tramadol in Male Rats. Antibiotics (Basel, Switzerland), 9(6). https://doi.org/10.3390/antibiotics9060318
Abdelaziz AS, et al. Chemotherapeutic Potential of Epimedium Brevicornum Extract: the cGMP-Specific PDE5 Inhibitor as Anti-Infertility Agent Following Long-Term Administration of Tramadol in Male Rats. Antibiotics (Basel). 2020 Jun 11;9(6) PubMed PMID: 32545153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemotherapeutic Potential of Epimedium brevicornum Extract: The cGMP-Specific PDE5 Inhibitor as Anti-Infertility Agent Following Long-Term Administration of Tramadol in Male Rats. AU - Abdelaziz,Ahmed S, AU - Kamel,Mohamed A, AU - Ahmed,Amany I, AU - Shalaby,Shimaa I, AU - El-Darier,Salama M, AU - Magdy Beshbishy,Amany, AU - Batiha,Gaber El-Saber, AU - Alomar,Suliman Y, AU - Khodeer,Dina M, Y1 - 2020/06/11/ PY - 2020/05/03/received PY - 2020/06/01/revised PY - 2020/06/05/accepted PY - 2020/6/18/entrez PY - 2020/6/18/pubmed PY - 2020/6/18/medline KW - Epimedium brevicornum Maxim KW - andrological parameters KW - male fertility KW - nitric oxide KW - tramadol JF - Antibiotics (Basel, Switzerland) JO - Antibiotics (Basel) VL - 9 IS - 6 N2 - Epimedium brevicornum Maxim (EbM) is a well-known Chinese herb that has been widely used for the treatment of several diseases. The main purpose of this study is to examine the role of Epimedium brevicornum extract in certain andrological parameters in rats as a natural modulator for adverse viewpoints associated with chronic administration of tramadol (TAM). Fifty rats were categorized into five groups. Untreated rats were known as Group I, whereas rats in Groups II and III were administered 2.43 g/kg/day of E. brevicornum extract and 50 mg/kg/day of TAM for 130 consecutive days, respectively. Both of Groups IV and V were administered TAM for 65 successive days, followed by concomitant use of both drugs for another 65 days, with the E. brevicornum extract at doses of 0.81 and 2.43 g/kg/day, respectively. TAM showed an injurious effect on sperm attributes, serum hormones, tissue malondialdehyde, superoxide dismutase, and nitric oxide. Elevation of the apoptotic marker Bax and a reduction of Bcl2 were recorded. Histopathological abnormalities have been reported in rat testicles. Rats treated with E. brevicornum extract with TAM showed an improvement in all the parameters tested. It could be presumed that E. brevicornum extract plus TAM exhibits a promising effect on the enhancement of male anti-infertility effects. SN - 2079-6382 UR - https://www.unboundmedicine.com/medline/citation/32545153/Chemotherapeutic_Potential_of_Epimedium_brevicornum_Extract:_The_cGMP-Specific_PDE5_Inhibitor_as_Anti-Infertility_Agent_Following_Long-Term_Administration_of_Tramadol_in_Male_Rats L2 - https://www.mdpi.com/resolver?pii=antibiotics9060318 DB - PRIME DP - Unbound Medicine ER -
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