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Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma.
Biomedicines. 2020 Jun 11; 8(6)B

Abstract

The treatment of advanced basal cell carcinoma has seen a progressive evolution in recent years following the introduction of Hedgehog pathway inhibitors. However, given the burden of mutations in the tumor microenvironment and lack of knowledge for the follow-up of advanced basal cell carcinoma, we are proposing a possible synergistic therapeutic application. Our aim is to underline the use of arsenic trioxide, itraconazole, all-trans-retinoic acid and nicotinamide as possible adjuvant therapies either in advanced not responding basal cell carcinoma or during follow-up based on Hedgehog pathway. We have analyzed the rational use of these drugs as a pivotal point to block neoplasm progression, modulate epigenetic modification and prevent recurrences.

Authors+Show Affiliations

Department of Dermatology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.Anatomic Pathology Unit, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.Dermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32545245

Citation

Cosio, Terenzio, et al. "Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: a Proof of Concept for Combined Treatments With Hedgehog Inhibitors in Advanced Basal Cell Carcinoma." Biomedicines, vol. 8, no. 6, 2020.
Cosio T, Di Prete M, Campione E. Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma. Biomedicines. 2020;8(6).
Cosio, T., Di Prete, M., & Campione, E. (2020). Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma. Biomedicines, 8(6). https://doi.org/10.3390/biomedicines8060156
Cosio T, Di Prete M, Campione E. Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: a Proof of Concept for Combined Treatments With Hedgehog Inhibitors in Advanced Basal Cell Carcinoma. Biomedicines. 2020 Jun 11;8(6) PubMed PMID: 32545245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma. AU - Cosio,Terenzio, AU - Di Prete,Monia, AU - Campione,Elena, Y1 - 2020/06/11/ PY - 2020/05/18/received PY - 2020/06/08/revised PY - 2020/06/09/accepted PY - 2020/6/18/entrez PY - 2020/6/18/pubmed PY - 2020/6/18/medline KW - Hedgehog signaling pathway KW - arsenic trioxide KW - basal cell carcinoma KW - itraconazole KW - nicotinamide KW - retinoic acid KW - smoothened receptors JF - Biomedicines JO - Biomedicines VL - 8 IS - 6 N2 - The treatment of advanced basal cell carcinoma has seen a progressive evolution in recent years following the introduction of Hedgehog pathway inhibitors. However, given the burden of mutations in the tumor microenvironment and lack of knowledge for the follow-up of advanced basal cell carcinoma, we are proposing a possible synergistic therapeutic application. Our aim is to underline the use of arsenic trioxide, itraconazole, all-trans-retinoic acid and nicotinamide as possible adjuvant therapies either in advanced not responding basal cell carcinoma or during follow-up based on Hedgehog pathway. We have analyzed the rational use of these drugs as a pivotal point to block neoplasm progression, modulate epigenetic modification and prevent recurrences. SN - 2227-9059 UR - https://www.unboundmedicine.com/medline/citation/32545245/Arsenic_Trioxide,_Itraconazole,_All-Trans_Retinoic_Acid_and_Nicotinamide:_A_Proof_of_Concept_for_Combined_Treatments_with_Hedgehog_Inhibitors_in_Advanced_Basal_Cell_Carcinoma L2 - https://www.mdpi.com/resolver?pii=biomedicines8060156 DB - PRIME DP - Unbound Medicine ER -
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