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Relationship between Auditory Evoked Potentials and Circadian Preference in Patients with Major Depressive Episodes.
Brain Sci. 2020 Jun 12; 10(6)BS

Abstract

Mood disorders often accompany circadian rhythm abnormalities. The serotonergic system (STS) is related to mood and circadian rhythm. This study aimed to test whether serotonergic neurotransmission, using the loudness dependence of auditory evoked potential (LDAEP), is associated with circadian preference in patients with major depressive disorder (MDD). Depression severity was assessed in 18-65-year-old outpatients (n = 48) using the Beck Depression Inventory scores and Hamilton Depression Rating Scale at baseline. Additionally, various scales, including the Korean version of the Composite Scale of Morningness (K-CSM), Korean version of the Mood Disorder Questionnaire (K-MDQ), and Korean version of the Childhood Trauma Questionnaire (K-CTQ), were used. LDAEP was also measured at baseline. The subjects were divided into three groups according to the circadian preference using total K-CSM scores (morningness (n = 10) vs intermediate (n = 19) vs. eveningness (n = 19)) and two groups according to median based on each K-CSM score, respectively (higher K-CSM (n = 25) vs. lower K-CSM (n = 23)). The bipolarity, suicidality, and age at onset differed among the three groups. Impulsivity, depression severity, suicidality, hopelessness, bipolarity, frequency of emotional abuse, and age at onset differed between the two group divisions. Thus, the STS might serve as the mediator between the circadian system and mood.

Authors+Show Affiliations

Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang 10380, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32545632

Citation

Park, Young-Min. "Relationship Between Auditory Evoked Potentials and Circadian Preference in Patients With Major Depressive Episodes." Brain Sciences, vol. 10, no. 6, 2020.
Park YM. Relationship between Auditory Evoked Potentials and Circadian Preference in Patients with Major Depressive Episodes. Brain Sci. 2020;10(6).
Park, Y. M. (2020). Relationship between Auditory Evoked Potentials and Circadian Preference in Patients with Major Depressive Episodes. Brain Sciences, 10(6). https://doi.org/10.3390/brainsci10060370
Park YM. Relationship Between Auditory Evoked Potentials and Circadian Preference in Patients With Major Depressive Episodes. Brain Sci. 2020 Jun 12;10(6) PubMed PMID: 32545632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between Auditory Evoked Potentials and Circadian Preference in Patients with Major Depressive Episodes. A1 - Park,Young-Min, Y1 - 2020/06/12/ PY - 2020/05/13/received PY - 2020/06/06/revised PY - 2020/06/09/accepted PY - 2020/6/18/entrez PY - 2020/6/18/pubmed PY - 2020/6/18/medline KW - childhood trauma KW - circadian preference KW - circadian rhythm KW - eveningness KW - major depressive disorder KW - morningness JF - Brain sciences JO - Brain Sci VL - 10 IS - 6 N2 - Mood disorders often accompany circadian rhythm abnormalities. The serotonergic system (STS) is related to mood and circadian rhythm. This study aimed to test whether serotonergic neurotransmission, using the loudness dependence of auditory evoked potential (LDAEP), is associated with circadian preference in patients with major depressive disorder (MDD). Depression severity was assessed in 18-65-year-old outpatients (n = 48) using the Beck Depression Inventory scores and Hamilton Depression Rating Scale at baseline. Additionally, various scales, including the Korean version of the Composite Scale of Morningness (K-CSM), Korean version of the Mood Disorder Questionnaire (K-MDQ), and Korean version of the Childhood Trauma Questionnaire (K-CTQ), were used. LDAEP was also measured at baseline. The subjects were divided into three groups according to the circadian preference using total K-CSM scores (morningness (n = 10) vs intermediate (n = 19) vs. eveningness (n = 19)) and two groups according to median based on each K-CSM score, respectively (higher K-CSM (n = 25) vs. lower K-CSM (n = 23)). The bipolarity, suicidality, and age at onset differed among the three groups. Impulsivity, depression severity, suicidality, hopelessness, bipolarity, frequency of emotional abuse, and age at onset differed between the two group divisions. Thus, the STS might serve as the mediator between the circadian system and mood. SN - 2076-3425 UR - https://www.unboundmedicine.com/medline/citation/32545632/Relationship_between_Auditory_Evoked_Potentials_and_Circadian_Preference_in_Patients_with_Major_Depressive_Episodes L2 - https://www.mdpi.com/resolver?pii=brainsci10060370 DB - PRIME DP - Unbound Medicine ER -
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