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Treatment of pseudobulbar affect in a mixed neurodegenerative disorder with compounded quinidine capsules and dextromethorphan cough syrup.
SAGE Open Med Case Rep. 2020; 8:2050313X20921076.SO

Abstract

An elderly woman admitted in our geriatric inpatient unit suffered from disturbing outbursts of crying and, less frequently, episodes of laughing. The patient was diagnosed with pseudobulbar affect related to a mixed neurodegenerative disorder. This condition is often underdiagnosed and undertreated, despite being relatively frequent in patients with neurodegenerative disorders. This case report describes the treatment of pseudobulbar affect in this patient. The only available treatment in Canada for this condition, antidepressants, was not effective for our patient. Dextromethorphan/quinidine is a good accepted alternative, but the combination is not marketed in Canada. To manage this problem, we used compounded quinidine capsules and dextromethorphan cough syrup. The crying of our patient improved significantly and rapidly after the initiation of this treatment. This case will help professionals to review their central role in treating this complex and disabling condition.

Authors+Show Affiliations

Department of Pharmacy, Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada.Department of Geriatric Medicine, Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada. Department of Family and Emergency Medicine, Université de Montréal, Montreal, Quebec, Canada.Department of Neurosciences, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.Department of Geriatric Medicine, Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32547756

Citation

Villeneuve, Yannick, et al. "Treatment of Pseudobulbar Affect in a Mixed Neurodegenerative Disorder With Compounded Quinidine Capsules and Dextromethorphan Cough Syrup." SAGE Open Medical Case Reports, vol. 8, 2020, p. 2050313X20921076.
Villeneuve Y, Cruz-Santiago D, Masson H, et al. Treatment of pseudobulbar affect in a mixed neurodegenerative disorder with compounded quinidine capsules and dextromethorphan cough syrup. SAGE Open Med Case Rep. 2020;8:2050313X20921076.
Villeneuve, Y., Cruz-Santiago, D., Masson, H., & Clerc, D. (2020). Treatment of pseudobulbar affect in a mixed neurodegenerative disorder with compounded quinidine capsules and dextromethorphan cough syrup. SAGE Open Medical Case Reports, 8, 2050313X20921076. https://doi.org/10.1177/2050313X20921076
Villeneuve Y, et al. Treatment of Pseudobulbar Affect in a Mixed Neurodegenerative Disorder With Compounded Quinidine Capsules and Dextromethorphan Cough Syrup. SAGE Open Med Case Rep. 2020;8:2050313X20921076. PubMed PMID: 32547756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of pseudobulbar affect in a mixed neurodegenerative disorder with compounded quinidine capsules and dextromethorphan cough syrup. AU - Villeneuve,Yannick, AU - Cruz-Santiago,Diana, AU - Masson,Helene, AU - Clerc,Doris, Y1 - 2020/06/03/ PY - 2019/08/31/received PY - 2020/03/27/accepted PY - 2020/6/18/entrez PY - 2020/6/18/pubmed PY - 2020/6/18/medline KW - Pseudobulbar affect KW - alternative Nuedexta® KW - compounded quinidine capsules KW - crying KW - dextromethorphan cough syrup KW - geriatrics KW - laughing KW - neurodegenerative disorder SP - 2050313X20921076 EP - 2050313X20921076 JF - SAGE open medical case reports JO - SAGE Open Med Case Rep VL - 8 N2 - An elderly woman admitted in our geriatric inpatient unit suffered from disturbing outbursts of crying and, less frequently, episodes of laughing. The patient was diagnosed with pseudobulbar affect related to a mixed neurodegenerative disorder. This condition is often underdiagnosed and undertreated, despite being relatively frequent in patients with neurodegenerative disorders. This case report describes the treatment of pseudobulbar affect in this patient. The only available treatment in Canada for this condition, antidepressants, was not effective for our patient. Dextromethorphan/quinidine is a good accepted alternative, but the combination is not marketed in Canada. To manage this problem, we used compounded quinidine capsules and dextromethorphan cough syrup. The crying of our patient improved significantly and rapidly after the initiation of this treatment. This case will help professionals to review their central role in treating this complex and disabling condition. SN - 2050-313X UR - https://www.unboundmedicine.com/medline/citation/32547756/Treatment_of_pseudobulbar_affect_in_a_mixed_neurodegenerative_disorder_with_compounded_quinidine_capsules_and_dextromethorphan_cough_syrup L2 - https://journals.sagepub.com/doi/10.1177/2050313X20921076?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=www.ncbi.nlm.nih.gov DB - PRIME DP - Unbound Medicine ER -
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