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Vitamin D and disease activity in rheumatoid arthritis patients: a retrospective study in a Romanian cohort.
Acta Biochim Pol. 2020 Jun 18; 67(2):267-272.AB

Abstract

BACKGROUND

The relationship between the serum levels of Vitamin D and the severity of RA is a subject of great interest for the future therapeutic strategies. Although the evidence on the relationship between hypovitaminosis D and early RA is contradictory, preliminary data suggest that the serum levels of vitamin D are inversely associated with the disease activity.

AIM

the main objectives of this study include: (1) to analyze the serum levels of vitamin D in patients with RA in comparison to healthy controls; (2) to investigatea possible correlation with disease activity.

MATERIALS AND METHODS

This was a retrospective, comparative study conducted on 37 subjects suffering from RA and a group of 21 healthy matched controls. The following were determined in all studied subjects: erythrocyte sedimentation rate (ESR), white blood cells (WBC), hemoglobin (Hb), platelets (PLT), serum calcium (Ca), serum phosphorus (Phos), and serum 25 hydroxy-vitamin D. Moreover, in the RA group the IgM-Rhematoid Factor (RF) and anti-citrullinated protein antibodies (ACPA) (immune-enzymatic method) were assessed. The Disease Activity Score of 28 joints (DAS28) was calculated for the RA patients.

RESULTS

We observed that vitamin D deficiency is more common in RA patients than in healthy controls. No significant correlation between 25OHvitD and DAS28-ESR was found in our study cohort.

CONCLUSIONS

There is no significant association of serum 25(OH)D with disease severity in a Western Romanian cohort with RA. However, this result could have implications for the disease management, as patients with RA could be supplemented with vitamin D even in the absence of disease activity.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Sirbu E
West University of Timişoara, Romania.
Buleu F
University of Medicine and Pharmacy "Victor Babeș", Timișoara, Romania.
Tudor A
University of Medicine and Pharmacy "Victor Babeș", Timișoara, Romania.
Dragan S
University of Medicine and Pharmacy "Victor Babeș", Timișoara, Romania.

MeSH

AdultAgedArthritis, RheumatoidBlood PlateletsBlood SedimentationCalciumFemaleHemoglobinsHumansLeukocytesMaleMiddle AgedPhosphorusRetrospective StudiesRomaniaSeverity of Illness IndexVitamin DVitamin D DeficiencyVitamins

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

32550709

Citation

Sirbu, Elena, et al. "Vitamin D and Disease Activity in Rheumatoid Arthritis Patients: a Retrospective Study in a Romanian Cohort." Acta Biochimica Polonica, vol. 67, no. 2, 2020, pp. 267-272.
Sirbu E, Buleu F, Tudor A, et al. Vitamin D and disease activity in rheumatoid arthritis patients: a retrospective study in a Romanian cohort. Acta Biochim Pol. 2020;67(2):267-272.
Sirbu, E., Buleu, F., Tudor, A., & Dragan, S. (2020). Vitamin D and disease activity in rheumatoid arthritis patients: a retrospective study in a Romanian cohort. Acta Biochimica Polonica, 67(2), 267-272. https://doi.org/10.18388/abp.2020_5360
Sirbu E, et al. Vitamin D and Disease Activity in Rheumatoid Arthritis Patients: a Retrospective Study in a Romanian Cohort. Acta Biochim Pol. 2020 Jun 18;67(2):267-272. PubMed PMID: 32550709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and disease activity in rheumatoid arthritis patients: a retrospective study in a Romanian cohort. AU - Sirbu,Elena, AU - Buleu,Florina, AU - Tudor,Anca, AU - Dragan,Simona, PY - 2020/05/03/received PY - 2020/06/02/accepted PY - 2020/6/19/pubmed PY - 2021/2/20/medline PY - 2020/6/19/entrez SP - 267 EP - 272 JF - Acta biochimica Polonica JO - Acta Biochim Pol VL - 67 IS - 2 N2 - BACKGROUND: The relationship between the serum levels of Vitamin D and the severity of RA is a subject of great interest for the future therapeutic strategies. Although the evidence on the relationship between hypovitaminosis D and early RA is contradictory, preliminary data suggest that the serum levels of vitamin D are inversely associated with the disease activity. AIM: the main objectives of this study include: (1) to analyze the serum levels of vitamin D in patients with RA in comparison to healthy controls; (2) to investigatea possible correlation with disease activity. MATERIALS AND METHODS: This was a retrospective, comparative study conducted on 37 subjects suffering from RA and a group of 21 healthy matched controls. The following were determined in all studied subjects: erythrocyte sedimentation rate (ESR), white blood cells (WBC), hemoglobin (Hb), platelets (PLT), serum calcium (Ca), serum phosphorus (Phos), and serum 25 hydroxy-vitamin D. Moreover, in the RA group the IgM-Rhematoid Factor (RF) and anti-citrullinated protein antibodies (ACPA) (immune-enzymatic method) were assessed. The Disease Activity Score of 28 joints (DAS28) was calculated for the RA patients. RESULTS: We observed that vitamin D deficiency is more common in RA patients than in healthy controls. No significant correlation between 25OHvitD and DAS28-ESR was found in our study cohort. CONCLUSIONS: There is no significant association of serum 25(OH)D with disease severity in a Western Romanian cohort with RA. However, this result could have implications for the disease management, as patients with RA could be supplemented with vitamin D even in the absence of disease activity. SN - 1734-154X UR - https://www.unboundmedicine.com/medline/citation/32550709/Vitamin_D_and_disease_activity_in_rheumatoid_arthritis_patients:_a_retrospective_study_in_a_Romanian_cohort_ DB - PRIME DP - Unbound Medicine ER -