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Formulation and optimization of liquisolid compact for enhancing dissolution properties of efavirenz by using DoE approach.
Saudi Pharm J. 2020 Jun; 28(6):737-745.SP

Abstract

Efavirenz displays low and variable bioavailability because of its poor aqueous solubility and high log P-value. The present investigation was aimed to improve the dissolution profile of efavirenz by using a simple, scalable and cost-effective technique of liquisolid compact. The drug was dissolved in Trancutol-HP for preparing the liquid medicament which was subsequently mixed with carrier and coating material to make free-flowing and compressible powder. 32 full factorial design was used to optimize the formulation in which the Neusilin US2/Corn starch ratios and carrier/coating material ratio were selected as independent variables. The results of in-vitro dissolution test proved that liquisolid compacts have significantly higher dissolution rate than tablets containing pure drug. Results of DSC and XRD studies suggested that the high dissolution of the drug from the liquisolid compacts was possibly because of the drug either being in an amorphous state or being molecularly dispersed within the internal matrix of compacts.

Authors+Show Affiliations

B.K. Mody Government Pharmacy College, Polytechnic Campus, Near Ajidam, Rajkot, Gujarat, India.B.K. Mody Government Pharmacy College, Polytechnic Campus, Near Ajidam, Rajkot, Gujarat, India.B.K. Mody Government Pharmacy College, Polytechnic Campus, Near Ajidam, Rajkot, Gujarat, India.B.K. Mody Government Pharmacy College, Polytechnic Campus, Near Ajidam, Rajkot, Gujarat, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32550806

Citation

Jaydip, Bhola, et al. "Formulation and Optimization of Liquisolid Compact for Enhancing Dissolution Properties of Efavirenz By Using DoE Approach." Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society, vol. 28, no. 6, 2020, pp. 737-745.
Jaydip B, Dhaval M, Soniwala MM, et al. Formulation and optimization of liquisolid compact for enhancing dissolution properties of efavirenz by using DoE approach. Saudi Pharm J. 2020;28(6):737-745.
Jaydip, B., Dhaval, M., Soniwala, M. M., & Chavda, J. (2020). Formulation and optimization of liquisolid compact for enhancing dissolution properties of efavirenz by using DoE approach. Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society, 28(6), 737-745. https://doi.org/10.1016/j.jsps.2020.04.016
Jaydip B, et al. Formulation and Optimization of Liquisolid Compact for Enhancing Dissolution Properties of Efavirenz By Using DoE Approach. Saudi Pharm J. 2020;28(6):737-745. PubMed PMID: 32550806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation and optimization of liquisolid compact for enhancing dissolution properties of efavirenz by using DoE approach. AU - Jaydip,Bhola, AU - Dhaval,Mori, AU - Soniwala,M M, AU - Chavda,Jayant, Y1 - 2020/05/08/ PY - 2019/12/20/received PY - 2020/04/29/accepted PY - 2020/6/20/entrez PY - 2020/6/20/pubmed PY - 2020/6/20/medline KW - Carrier coater ratio KW - DoE approach KW - Efavirenz KW - Liquid loading factor KW - Liquisolid technique KW - Optimization SP - 737 EP - 745 JF - Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society JO - Saudi Pharm J VL - 28 IS - 6 N2 - Efavirenz displays low and variable bioavailability because of its poor aqueous solubility and high log P-value. The present investigation was aimed to improve the dissolution profile of efavirenz by using a simple, scalable and cost-effective technique of liquisolid compact. The drug was dissolved in Trancutol-HP for preparing the liquid medicament which was subsequently mixed with carrier and coating material to make free-flowing and compressible powder. 32 full factorial design was used to optimize the formulation in which the Neusilin US2/Corn starch ratios and carrier/coating material ratio were selected as independent variables. The results of in-vitro dissolution test proved that liquisolid compacts have significantly higher dissolution rate than tablets containing pure drug. Results of DSC and XRD studies suggested that the high dissolution of the drug from the liquisolid compacts was possibly because of the drug either being in an amorphous state or being molecularly dispersed within the internal matrix of compacts. SN - 1319-0164 UR - https://www.unboundmedicine.com/medline/citation/32550806/Formulation_and_optimization_of_liquisolid_compact_for_enhancing_dissolution_properties_of_efavirenz_by_using_DoE_approach L2 - https://linkinghub.elsevier.com/retrieve/pii/S1319-0164(20)30102-X DB - PRIME DP - Unbound Medicine ER -
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