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In sickness and in health: pivotal role of vitamin D.
Biochem Med (Zagreb). 2020 Jun 15; 30(2):020501.BM

Abstract

Within the last several years, frequency of vitamin D testing has multiplied substantially all over the world, since it has been shown to have an important role in many diseases and conditions. Even though liquid chromatography - tandem mass spectrometry (LC-MS/MS) has been identified as "gold standard" method for vitamin D measurement, most laboratories still use immunochemistry methods. Besides analytical problems (hydrophobicity, low circulating concentrations, ability to bind to lipids, albumins and vitamin D binding protein, presence of multiple vitamin D metabolites and variable ratios of 25(OH)D2 and 25(OH)D3 in the blood), vitamin D shows great preanalytical variability, since its concentration is drastically influenced by seasonal changes, exposure to sun, type of clothes or sun block creams. Vitamin D is mostly measured in serum or plasma, but new studies are showing importance of measuring vitamin D in pleural effusions, breast milk, urine, synovial fluid and saliva. Besides the main role in calcium homeostasis and bone metabolism, many studies linked vitamin D deficiency with cancer, cardiovascular diseases, diabetes, fertility and many other conditions. However, even though initial observational studies indicated that supplementation with vitamin D might be beneficial in disease development and progression; first results of well-designed randomized controlled prospective studies did not find differences in frequency of cardiovascular events or invasive cancer between patients taking vitamin D supplementation compared to placebo. In the light of these recent findings, validity of excessive vitamin D testing remains an open question.

Authors+Show Affiliations

Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia. Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.Department of Human Reproduction, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.Department for Endocrinology, Dieabetes and Metabolism, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32550812

Citation

Nikolac Gabaj, Nora, et al. "In Sickness and in Health: Pivotal Role of Vitamin D." Biochemia Medica, vol. 30, no. 2, 2020, p. 020501.
Nikolac Gabaj N, Unic A, Miler M, et al. In sickness and in health: pivotal role of vitamin D. Biochem Med (Zagreb). 2020;30(2):020501.
Nikolac Gabaj, N., Unic, A., Miler, M., Pavicic, T., Culej, J., Bolanca, I., Herman Mahecic, D., Milevoj Kopcinovic, L., & Vrtaric, A. (2020). In sickness and in health: pivotal role of vitamin D. Biochemia Medica, 30(2), 020501. https://doi.org/10.11613/BM.2020.020501
Nikolac Gabaj N, et al. In Sickness and in Health: Pivotal Role of Vitamin D. Biochem Med (Zagreb). 2020 Jun 15;30(2):020501. PubMed PMID: 32550812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In sickness and in health: pivotal role of vitamin D. AU - Nikolac Gabaj,Nora, AU - Unic,Adriana, AU - Miler,Marijana, AU - Pavicic,Tomislav, AU - Culej,Jelena, AU - Bolanca,Ivan, AU - Herman Mahecic,Davorka, AU - Milevoj Kopcinovic,Lara, AU - Vrtaric,Alen, PY - 2020/01/29/received PY - 2020/04/19/accepted PY - 2020/6/20/entrez PY - 2020/6/20/pubmed PY - 2021/1/27/medline KW - diabetes mellitus KW - extravascular body fluids KW - fertility KW - polymorphism KW - preanalytical variability KW - vitamin D SP - 020501 EP - 020501 JF - Biochemia medica JO - Biochem Med (Zagreb) VL - 30 IS - 2 N2 - Within the last several years, frequency of vitamin D testing has multiplied substantially all over the world, since it has been shown to have an important role in many diseases and conditions. Even though liquid chromatography - tandem mass spectrometry (LC-MS/MS) has been identified as "gold standard" method for vitamin D measurement, most laboratories still use immunochemistry methods. Besides analytical problems (hydrophobicity, low circulating concentrations, ability to bind to lipids, albumins and vitamin D binding protein, presence of multiple vitamin D metabolites and variable ratios of 25(OH)D2 and 25(OH)D3 in the blood), vitamin D shows great preanalytical variability, since its concentration is drastically influenced by seasonal changes, exposure to sun, type of clothes or sun block creams. Vitamin D is mostly measured in serum or plasma, but new studies are showing importance of measuring vitamin D in pleural effusions, breast milk, urine, synovial fluid and saliva. Besides the main role in calcium homeostasis and bone metabolism, many studies linked vitamin D deficiency with cancer, cardiovascular diseases, diabetes, fertility and many other conditions. However, even though initial observational studies indicated that supplementation with vitamin D might be beneficial in disease development and progression; first results of well-designed randomized controlled prospective studies did not find differences in frequency of cardiovascular events or invasive cancer between patients taking vitamin D supplementation compared to placebo. In the light of these recent findings, validity of excessive vitamin D testing remains an open question. SN - 1846-7482 UR - https://www.unboundmedicine.com/medline/citation/32550812/In_sickness_and_in_health:_pivotal_role_of_vitamin_D. L2 - http://www.biochemia-medica.com/2020/30/020501 DB - PRIME DP - Unbound Medicine ER -