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The unique characteristics of COVID-19 coagulopathy.
Crit Care. 2020 06 18; 24(1):360.CC

Abstract

Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC), with CAC usually showing increased D-dimer and fibrinogen levels but initially minimal abnormalities in prothrombin time and platelet count. Venous thromboembolism and arterial thrombosis are more frequent in CAC compared to SIC/DIC. Clinical and laboratory features of CAC overlap somewhat with a hemophagocytic syndrome, antiphospholipid syndrome, and thrombotic microangiopathy. We summarize the key characteristics of representative coagulopathies, discussing similarities and differences so as to define the unique character of CAC.

Authors+Show Affiliations

Department of Emergency and Disaster Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, 113-8421, Japan. toshiiba@juntendo.ac.jp.Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, NC, USA.Hematology Division Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.Department of Pathology and Molecular Medicine, and Department of Medicine, McMaster University, Hamilton, Canada.Department of Haematology, Manchester Royal Infirmary, Manchester, UK.Department of Medicine, University College London Hospitals NHS Foundation Trust and Cardio-metabolic Programme-NIHR UCLH/UCL BRC London, London, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32552865

Citation

Iba, Toshiaki, et al. "The Unique Characteristics of COVID-19 Coagulopathy." Critical Care (London, England), vol. 24, no. 1, 2020, p. 360.
Iba T, Levy JH, Connors JM, et al. The unique characteristics of COVID-19 coagulopathy. Crit Care. 2020;24(1):360.
Iba, T., Levy, J. H., Connors, J. M., Warkentin, T. E., Thachil, J., & Levi, M. (2020). The unique characteristics of COVID-19 coagulopathy. Critical Care (London, England), 24(1), 360. https://doi.org/10.1186/s13054-020-03077-0
Iba T, et al. The Unique Characteristics of COVID-19 Coagulopathy. Crit Care. 2020 06 18;24(1):360. PubMed PMID: 32552865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The unique characteristics of COVID-19 coagulopathy. AU - Iba,Toshiaki, AU - Levy,Jerrold H, AU - Connors,Jean Marie, AU - Warkentin,Theodore E, AU - Thachil,Jecko, AU - Levi,Marcel, Y1 - 2020/06/18/ PY - 2020/05/25/received PY - 2020/06/08/accepted PY - 2020/6/20/entrez PY - 2020/6/20/pubmed PY - 2020/7/4/medline KW - Antiphospholipid syndrome KW - COVID-19 KW - Coagulopathy KW - Disseminated intravascular coagulation KW - Hemophagocytic syndrome KW - Thrombotic microangiopathy SP - 360 EP - 360 JF - Critical care (London, England) JO - Crit Care VL - 24 IS - 1 N2 - Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC), with CAC usually showing increased D-dimer and fibrinogen levels but initially minimal abnormalities in prothrombin time and platelet count. Venous thromboembolism and arterial thrombosis are more frequent in CAC compared to SIC/DIC. Clinical and laboratory features of CAC overlap somewhat with a hemophagocytic syndrome, antiphospholipid syndrome, and thrombotic microangiopathy. We summarize the key characteristics of representative coagulopathies, discussing similarities and differences so as to define the unique character of CAC. SN - 1466-609X UR - https://www.unboundmedicine.com/medline/citation/32552865/The_unique_characteristics_of_COVID_19_coagulopathy_ L2 - https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03077-0 DB - PRIME DP - Unbound Medicine ER -