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[Collagen Peptides Improve Lymphocyte Distribution in Peripheral Blood and T Lymphocyte Proliferation in Spleen of Mice under the Condition of Simulated Weightlessness].
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Jun; 28(3):1001-1005.ZS

Abstract

OBJECTIVE

To investigate whether collagen peptides can improve the immune functions of mice under the condition of simulated weightlessness.

METHODS

Mouse tail-suspension model was used to simulate the effects of weightlessness. Tail-suspended mice were intraperitoneally injected with 600 mg collagen peptides per kilogram body weight once a day for 10 days. Then, the mice were killed, and white blood cells were counted and classified. Lymphocyte subsets and T lymphocyte proliferations in spleens were analyzed.

RESULTS

Compared with normal control group, total and differential count of leukocytes, lymphocytes, T cells,CD4+ and CD8+ T cells, B cells and NK cells, and splenic T lymphocyte proliferation all decreased in the weightlessness simulated mice (P<0.05). Except for NK cells, the above-mentioned parameters were increased after administration of collagen peptides, and some of the parameters were recovered to the levels of normal control mice (P<0.05).

CONCLUSION

Collagen peptides can effectively improve peripheral blood lymphocyte distributions and T lymphocyte proliferations of mice under the condition of simulated weightlessness. This study nay provid the experimental basis for improvement of immune functions of astronauts.

Authors+Show Affiliations

Center for Special Medicine and Experimental Research, Medical Center of PLA Strategic Support Force, Beijing 100101, China.Center for Special Medicine and Experimental Research, Medical Center of PLA Strategic Support Force, Beijing 100101, China.Center for Special Medicine and Experimental Research, Medical Center of PLA Strategic Support Force, Beijing 100101, China.Center for Special Medicine and Experimental Research, Medical Center of PLA Strategic Support Force, Beijing 100101, China.Center for Special Medicine and Experimental Research, Medical Center of PLA Strategic Support Force, Beijing 100101, China.Center for Special Medicine and Experimental Research, Medical Center of PLA Strategic Support Force, Beijing 100101, China,E-mail:shuj80@126.com.

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

32552972

Citation

Si, Shao-Yan, et al. "[Collagen Peptides Improve Lymphocyte Distribution in Peripheral Blood and T Lymphocyte Proliferation in Spleen of Mice Under the Condition of Simulated Weightlessness]." Zhongguo Shi Yan Xue Ye Xue Za Zhi, vol. 28, no. 3, 2020, pp. 1001-1005.
Si SY, Xu BX, Wu YY, et al. [Collagen Peptides Improve Lymphocyte Distribution in Peripheral Blood and T Lymphocyte Proliferation in Spleen of Mice under the Condition of Simulated Weightlessness]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020;28(3):1001-1005.
Si, S. Y., Xu, B. X., Wu, Y. Y., Qin, Y. Y., Duan, R., & Song, S. J. (2020). [Collagen Peptides Improve Lymphocyte Distribution in Peripheral Blood and T Lymphocyte Proliferation in Spleen of Mice under the Condition of Simulated Weightlessness]. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 28(3), 1001-1005. https://doi.org/10.19746/j.cnki.issn.1009-2137.2020.03.047
Si SY, et al. [Collagen Peptides Improve Lymphocyte Distribution in Peripheral Blood and T Lymphocyte Proliferation in Spleen of Mice Under the Condition of Simulated Weightlessness]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020;28(3):1001-1005. PubMed PMID: 32552972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Collagen Peptides Improve Lymphocyte Distribution in Peripheral Blood and T Lymphocyte Proliferation in Spleen of Mice under the Condition of Simulated Weightlessness]. AU - Si,Shao-Yan, AU - Xu,Bing-Xin, AU - Wu,Ying-Ying, AU - Qin,Ya-Ya, AU - Duan,Ran, AU - Song,Shu-Jun, PY - 2020/6/20/entrez SP - 1001 EP - 1005 JF - Zhongguo shi yan xue ye xue za zhi JO - Zhongguo Shi Yan Xue Ye Xue Za Zhi VL - 28 IS - 3 N2 - OBJECTIVE: To investigate whether collagen peptides can improve the immune functions of mice under the condition of simulated weightlessness. METHODS: Mouse tail-suspension model was used to simulate the effects of weightlessness. Tail-suspended mice were intraperitoneally injected with 600 mg collagen peptides per kilogram body weight once a day for 10 days. Then, the mice were killed, and white blood cells were counted and classified. Lymphocyte subsets and T lymphocyte proliferations in spleens were analyzed. RESULTS: Compared with normal control group, total and differential count of leukocytes, lymphocytes, T cells,CD4+ and CD8+ T cells, B cells and NK cells, and splenic T lymphocyte proliferation all decreased in the weightlessness simulated mice (P<0.05). Except for NK cells, the above-mentioned parameters were increased after administration of collagen peptides, and some of the parameters were recovered to the levels of normal control mice (P<0.05). CONCLUSION: Collagen peptides can effectively improve peripheral blood lymphocyte distributions and T lymphocyte proliferations of mice under the condition of simulated weightlessness. This study nay provid the experimental basis for improvement of immune functions of astronauts. SN - 1009-2137 UR - https://www.unboundmedicine.com/medline/citation/32552972/[Collagen_Peptides_Improve_Lymphocyte_Distribution_in_Peripheral_Blood_and_T_Lymphocyte_Proliferation_in_Spleen_of_Mice_under_the_Condition_of_Simulated_Weightlessness] DB - PRIME DP - Unbound Medicine ER -
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