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Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications.
Euro Surveill. 2020 06; 25(23)ES

Abstract

We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with ≤ 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be ≤ 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.

Authors+Show Affiliations

Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.Netherlands Institute for Health Services Research (NIVEL), Utrecht, the Netherlands.Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.Department of Hematology and Oncology, University of Milan, Milan, Italy. Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.MRC Centre for Environment and Health, School of Public Health, Imperial College, London, United Kingdom.Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

32553061

Citation

Caini, Saverio, et al. "Meta-analysis of Diagnostic Performance of Serological Tests for SARS-CoV-2 Antibodies Up to 25 April 2020 and Public Health Implications." Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, vol. 25, no. 23, 2020.
Caini S, Bellerba F, Corso F, et al. Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications. Euro Surveill. 2020;25(23).
Caini, S., Bellerba, F., Corso, F., Díaz-Basabe, A., Natoli, G., Paget, J., Facciotti, F., De Angelis, S. P., Raimondi, S., Palli, D., Mazzarella, L., Pelicci, P. G., Vineis, P., & Gandini, S. (2020). Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications. Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, 25(23). https://doi.org/10.2807/1560-7917.ES.2020.25.23.2000980
Caini S, et al. Meta-analysis of Diagnostic Performance of Serological Tests for SARS-CoV-2 Antibodies Up to 25 April 2020 and Public Health Implications. Euro Surveill. 2020;25(23) PubMed PMID: 32553061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications. AU - Caini,Saverio, AU - Bellerba,Federica, AU - Corso,Federica, AU - Díaz-Basabe,Angélica, AU - Natoli,Gioacchino, AU - Paget,John, AU - Facciotti,Federica, AU - De Angelis,Simone Pietro, AU - Raimondi,Sara, AU - Palli,Domenico, AU - Mazzarella,Luca, AU - Pelicci,Pier Giuseppe, AU - Vineis,Paolo, AU - Gandini,Sara, PY - 2020/6/20/entrez PY - 2020/6/20/pubmed PY - 2020/6/27/medline KW - SARS-CoV-2 KW - meta-analysis KW - predictive values KW - sensitivity KW - serological tests KW - specificity KW - systematic review JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin JO - Euro Surveill VL - 25 IS - 23 N2 - We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with ≤ 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be ≤ 88%. Serological tests should be used for prevalence surveys only in hard-hit areas. SN - 1560-7917 UR - https://www.unboundmedicine.com/medline/citation/32553061/Meta_analysis_of_diagnostic_performance_of_serological_tests_for_SARS_CoV_2_antibodies_up_to_25_April_2020_and_public_health_implications_ L2 - http://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.23.2000980 DB - PRIME DP - Unbound Medicine ER -