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Serial change of perivascular fat attenuation index after statin treatment: Insights from a coronary CT angiography follow-up study.
Int J Cardiol. 2020 11 15; 319:144-149.IJ

Abstract

BACKGROUND

Perivascular fat attenuation index (FAI) was thought to be an indicator of active vessel inflammation surrounding coronary plaques. However, whether this index can be reduced by statin treatment remains unknown. We aimed to investigate the serial change of lesion-specific perivascular FAI as quantified by coronary computed tomography (CCTA) after statin treatment.

METHODS

Consecutive patients with chest pain and intermediate likelihood of coronary artery disease were referred for baseline CCTA. Patients were retrospectively included if they were treated medically and underwent follow-up CCTA at 1-year to 1.5-year interval. Lesion-specific perivascular FAI, as well as other plaque features, were measured at baseline and follow-up.

RESULTS

One hundred and eight patients (mean age 67.7 ± 11.1, 76 males) were included. A significant reduction of the FAI value was found for non-calcified plaques and mixed plaques (-68.0 HU ± 8.5 HU Vs. -71.5 HU ± 8.1 HU, p < .001 and - 70.5 HU ± 8.9 HU Vs. -72.8 HU ± 9.0 HU, p = .014). However, this improvement was not observed for calcified plaques (-70.6 HU ± 9.7 HU Vs. -71.7 HU ± 9.9 HU, p = .258). For non-calcified and mixed plaques, the volumes of non-calcified as well as low attenuation component was significantly reduced whereas total plaque volume and volume of calcified component increased. For calcified plaque, total plaque volume also demonstrated remarkable increase after statin treatment CONCLUSIONS: Lesion-specific perivascular FAI decreased at mid-term follow-up after statin treatment for non-calcified and mixed plaques. Perivascular FAI can be a potential imaging biomarker to monitor the anti-inflammation response to statin treatments.

Authors+Show Affiliations

Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, #600, Yishan Rd, Shanghai, China.Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, #600, Yishan Rd, Shanghai, China.Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, #600, Yishan Rd, Shanghai, China.Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, #600, Yishan Rd, Shanghai, China.Siemens Healthineers, #278, Zhouzhugong Rd, Shanghai, China.Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, #600, Yishan Rd, Shanghai, China. Electronic address: andrewssmu@msn.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32553595

Citation

Dai, Xu, et al. "Serial Change of Perivascular Fat Attenuation Index After Statin Treatment: Insights From a Coronary CT Angiography Follow-up Study." International Journal of Cardiology, vol. 319, 2020, pp. 144-149.
Dai X, Yu L, Lu Z, et al. Serial change of perivascular fat attenuation index after statin treatment: Insights from a coronary CT angiography follow-up study. Int J Cardiol. 2020;319:144-149.
Dai, X., Yu, L., Lu, Z., Shen, C., Tao, X., & Zhang, J. (2020). Serial change of perivascular fat attenuation index after statin treatment: Insights from a coronary CT angiography follow-up study. International Journal of Cardiology, 319, 144-149. https://doi.org/10.1016/j.ijcard.2020.06.008
Dai X, et al. Serial Change of Perivascular Fat Attenuation Index After Statin Treatment: Insights From a Coronary CT Angiography Follow-up Study. Int J Cardiol. 2020 11 15;319:144-149. PubMed PMID: 32553595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serial change of perivascular fat attenuation index after statin treatment: Insights from a coronary CT angiography follow-up study. AU - Dai,Xu, AU - Yu,Lihua, AU - Lu,Zhigang, AU - Shen,Chengxing, AU - Tao,Xinwei, AU - Zhang,Jiayin, Y1 - 2020/06/15/ PY - 2020/05/02/received PY - 2020/06/06/revised PY - 2020/06/09/accepted PY - 2020/6/20/pubmed PY - 2021/4/29/medline PY - 2020/6/20/entrez KW - Coronary artery disease KW - Coronary computed tomography angiography KW - Fat attenuation index KW - Perivascular adipose tissue KW - Statin SP - 144 EP - 149 JF - International journal of cardiology JO - Int J Cardiol VL - 319 N2 - BACKGROUND: Perivascular fat attenuation index (FAI) was thought to be an indicator of active vessel inflammation surrounding coronary plaques. However, whether this index can be reduced by statin treatment remains unknown. We aimed to investigate the serial change of lesion-specific perivascular FAI as quantified by coronary computed tomography (CCTA) after statin treatment. METHODS: Consecutive patients with chest pain and intermediate likelihood of coronary artery disease were referred for baseline CCTA. Patients were retrospectively included if they were treated medically and underwent follow-up CCTA at 1-year to 1.5-year interval. Lesion-specific perivascular FAI, as well as other plaque features, were measured at baseline and follow-up. RESULTS: One hundred and eight patients (mean age 67.7 ± 11.1, 76 males) were included. A significant reduction of the FAI value was found for non-calcified plaques and mixed plaques (-68.0 HU ± 8.5 HU Vs. -71.5 HU ± 8.1 HU, p < .001 and - 70.5 HU ± 8.9 HU Vs. -72.8 HU ± 9.0 HU, p = .014). However, this improvement was not observed for calcified plaques (-70.6 HU ± 9.7 HU Vs. -71.7 HU ± 9.9 HU, p = .258). For non-calcified and mixed plaques, the volumes of non-calcified as well as low attenuation component was significantly reduced whereas total plaque volume and volume of calcified component increased. For calcified plaque, total plaque volume also demonstrated remarkable increase after statin treatment CONCLUSIONS: Lesion-specific perivascular FAI decreased at mid-term follow-up after statin treatment for non-calcified and mixed plaques. Perivascular FAI can be a potential imaging biomarker to monitor the anti-inflammation response to statin treatments. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/32553595/Serial_change_of_perivascular_fat_attenuation_index_after_statin_treatment:_Insights_from_a_coronary_CT_angiography_follow_up_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(20)33386-6 DB - PRIME DP - Unbound Medicine ER -