Citation
Izquierdo-Domínguez, A, et al. "Smell and Taste Dysfunction in COVID-19 Is Associated With Younger Age in Ambulatory Settings: a Multicenter Cross-Sectional Study." Journal of Investigational Allergology & Clinical Immunology, vol. 30, no. 5, 2020, pp. 346-357.
Izquierdo-Domínguez A, Rojas-Lechuga MJ, Chiesa-Estomba C, et al. Smell and Taste Dysfunction in COVID-19 Is Associated With Younger Age in Ambulatory Settings: A Multicenter Cross-Sectional Study. J Investig Allergol Clin Immunol. 2020;30(5):346-357.
Izquierdo-Domínguez, A., Rojas-Lechuga, M. J., Chiesa-Estomba, C., Calvo-Henríquez, C., Ninchritz-Becerra, E., Soriano-Reixach, M., Poletti-Serafini, D., Villarreal, I. M., Maza-Solano, J. M., Moreno-Luna, R., Villarroel, P. P., Mateos-Serrano, B., Agudelo, D., Valcarcel, F., Del Cuvillo, A., Santamaría, A., Mariño-Sánchez, F., Aguilar, J., Vergés, P., ... Alobid, I. (2020). Smell and Taste Dysfunction in COVID-19 Is Associated With Younger Age in Ambulatory Settings: A Multicenter Cross-Sectional Study. Journal of Investigational Allergology & Clinical Immunology, 30(5), 346-357. https://doi.org/10.18176/jiaci.0595
Izquierdo-Domínguez A, et al. Smell and Taste Dysfunction in COVID-19 Is Associated With Younger Age in Ambulatory Settings: a Multicenter Cross-Sectional Study. J Investig Allergol Clin Immunol. 2020;30(5):346-357. PubMed PMID: 32554337.
TY - JOUR
T1 - Smell and Taste Dysfunction in COVID-19 Is Associated With Younger Age in Ambulatory Settings: A Multicenter Cross-Sectional Study.
AU - Izquierdo-Domínguez,A,
AU - Rojas-Lechuga,M J,
AU - Chiesa-Estomba,C,
AU - Calvo-Henríquez,C,
AU - Ninchritz-Becerra,E,
AU - Soriano-Reixach,M,
AU - Poletti-Serafini,D,
AU - Villarreal,I M,
AU - Maza-Solano,J M,
AU - Moreno-Luna,R,
AU - Villarroel,P P,
AU - Mateos-Serrano,B,
AU - Agudelo,D,
AU - Valcarcel,F,
AU - Del Cuvillo,A,
AU - Santamaría,A,
AU - Mariño-Sánchez,F,
AU - Aguilar,J,
AU - Vergés,P,
AU - Inciarte,A,
AU - Soriano,A,
AU - Mullol,J,
AU - Alobid,I,
Y1 - 2020/06/17/
PY - 2020/6/20/pubmed
PY - 2020/10/21/medline
PY - 2020/6/20/entrez
KW - COVID-19
KW - Hospital admission
KW - Loss of smell
KW - Loss of taste
KW - SARS-CoV-2
SP - 346
EP - 357
JF - Journal of investigational allergology & clinical immunology
JO - J Investig Allergol Clin Immunol
VL - 30
IS - 5
N2 - BACKGROUND AND OBJECTIVE: Since the initial anecdotal reports of coronavirus disease 2019 (COVID-19) from China, a growing number of studies have reported on smell and/or taste dysfunction (STD). Objective: The aim of our study was to investigate the frequency and severity of STD in COVID-19 patients and to evaluate the association with demographic characteristics, hospital admission, symptoms, comorbidities, and blood biomarkers. METHODS: We performed a multicenter cross-sectional study on patients who were positive for SARS-CoV-2 (n=846) and controls (n=143) from 15 Spanish hospitals. Data on STD were collected prospectively using an in-person survey. The severity of STD was categorized using a visual analog scale. We analyzed time to onset, recovery rate, time to recovery, hospital admission, pneumonia, comorbidities, smoking, and symptoms. RESULTS: STD was at least 2-fold more common in COVID-19-positive patients than in controls. COVID-19-positive hospitalized patients were older, with a lower frequency of STD, and recovered earlier than outpatients. Analysis stratified by severity of STD showed that more than half of COVID-19 patients presented severe loss of smell (53.7%) or taste (52.2%); both senses were impaired in >90%. In the multivariate analysis, older age (>60 years), being hospitalized, and increased C-reactive protein were associated with a better sense of smell and/or taste. COVID-19-positive patients reported improvement in smell (45.6%) and taste (46.1%) at the time of the survey; in 90.6% this was within 2 weeks of infection. CONCLUSION: STD is a common symptom in COVID-19 and presents mainly in young and nonhospitalized patients. More studies are needed to evaluate follow-up of chemosensory impairment.
SN - 1018-9068
UR - https://www.unboundmedicine.com/medline/citation/32554337/Smell_and_Taste_Dysfunction_in_COVID_19_Is_Associated_With_Younger_Age_in_Ambulatory_Settings:_A_Multicenter_Cross_Sectional_Study_
DB - PRIME
DP - Unbound Medicine
ER -