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Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19.
Elife. 2020 06 19; 9E

Abstract

Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus disease 2019 (COVID-19) also tested positive for SARS-CoV-2 (Rivett et al., 2020). Here, we show that the proportion of both asymptomatic and symptomatic HCWs testing positive for SARS-CoV-2 rapidly declined to near-zero between 25th April and 24th May 2020, corresponding to a decline in patient admissions with COVID-19 during the ongoing UK 'lockdown'. These data demonstrate how infection prevention and control measures including staff testing may help prevent hospitals from becoming independent 'hubs' of SARS-CoV-2 transmission, and illustrate how, with appropriate precautions, organizations in other sectors may be able to resume on-site work safely.

Authors+Show Affiliations

Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Clinical Microbiology & Public Health Laboratory, Public Health England, Cambridge, United Kingdom. Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Clinical Microbiology & Public Health Laboratory, Public Health England, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Clinical Microbiology & Public Health Laboratory, Public Health England, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom. Wellcome Sanger Institute, Hinxton, United Kingdom.Academic Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom. Department of Haematology, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Clinical Microbiology & Public Health Laboratory, Public Health England, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Institute for Manufacturing, Department of Engineering, University of Cambridge, Cambridge, United Kingdom.Institute for Manufacturing, Department of Engineering, University of Cambridge, Cambridge, United Kingdom.Institute for Manufacturing, Department of Engineering, University of Cambridge, Cambridge, United Kingdom.Improvement and Transformation Team, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.Occupational Health and Wellbeing, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.Cancer Research United Kingdom Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.Cancer Research United Kingdom Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.No affiliation info availableNo affiliation info 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affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableClinical Microbiology & Public Health Laboratory, Public Health England, Cambridge, United Kingdom.National Institutes for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. National Institutes for Health Research Cambridge, Clinical Research Facility, Cambridge, United Kingdom.Cancer Research United Kingdom Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Occupational Health and Wellbeing, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom. NHS Blood and Transplant, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32558644

Citation

Jones, Nick K., et al. "Effective Control of SARS-CoV-2 Transmission Between Healthcare Workers During a Period of Diminished Community Prevalence of COVID-19." ELife, vol. 9, 2020.
Jones NK, Rivett L, Sparkes D, et al. Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19. Elife. 2020;9.
Jones, N. K., Rivett, L., Sparkes, D., Forrest, S., Sridhar, S., Young, J., Pereira-Dias, J., Cormie, C., Gill, H., Reynolds, N., Wantoch, M., Routledge, M., Warne, B., Levy, J., Córdova Jiménez, W. D., Samad, F. N. B., McNicholas, C., Ferris, M., Gray, J., ... Weekes, M. P. (2020). Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19. ELife, 9. https://doi.org/10.7554/eLife.59391
Jones NK, et al. Effective Control of SARS-CoV-2 Transmission Between Healthcare Workers During a Period of Diminished Community Prevalence of COVID-19. Elife. 2020 06 19;9 PubMed PMID: 32558644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19. AU - Jones,Nick K, AU - Rivett,Lucy, AU - Sparkes,Dominic, AU - Forrest,Sally, AU - Sridhar,Sushmita, AU - Young,Jamie, AU - Pereira-Dias,Joana, AU - Cormie,Claire, AU - Gill,Harmeet, AU - Reynolds,Nicola, AU - Wantoch,Michelle, AU - Routledge,Matthew, AU - Warne,Ben, AU - Levy,Jack, AU - Córdova Jiménez,William David, AU - Samad,Fathima Nisha Begum, AU - McNicholas,Chris, AU - Ferris,Mark, AU - Gray,Jane, AU - Gill,Michael, AU - ,, AU - Baker,Stephen, AU - Bradley,John, AU - Dougan,Gordon, AU - Goodfellow,Ian, AU - Gupta,Ravi, AU - Lehner,Paul J, AU - Lyons,Paul A, AU - Matheson,Nicholas J, AU - Smith,Kenneth Gc, AU - Torok,M Estee, AU - Toshner,Mark, AU - Weekes,Michael P, AU - Jones,Nicholas K, AU - Rivett,Lucy, AU - Routledge,Matthew, AU - Sparkes,Dominic, AU - Warne,Ben, AU - Cormie,Claire, AU - Forrest,Sally, AU - Gill,Harmeet, AU - Kean,Iain, AU - Pereira-Dias,Joana, AU - Reynolds,Nicola, AU - Sridhar,Sushmita, AU - Wantoch,Michelle, AU - Young,Jamie, AU - Caddy,Sarah, AU - Caller,Laura, AU - Feltwell,Theresa, AU - Hall,Grant, AU - Hamilton,William, AU - Hosmillo,Myra, AU - Houldcroft,Charlotte, AU - Jahun,Aminu, AU - Khokhar,Fahad, AU - Meredith,Luke, AU - Yakovleva,Anna, AU - Butcher,Helen, AU - Caputo,Daniela, AU - Clapham-Riley,Debra, AU - Dolling,Helen, AU - Furlong,Anita, AU - Graves,Barbara, AU - Le Gresley,Emma, AU - Kingston,Nathalie, AU - Papadia,Sofia, AU - Stark,Hannah, AU - Stirrups,Kathleen E, AU - Webster,Jennifer, AU - Calder,Joanna, AU - Harris,Julie, AU - Hewitt,Sarah, AU - Kennet,Jane, AU - Meadows,Anne, AU - Rastall,Rebecca, AU - Brien,Criona O, AU - Price,Jo, AU - Publico,Cherry, AU - Rowlands,Jane, AU - Ruffolo,Valentina, AU - Tordesillas,Hugo, AU - Gill,Michael, AU - Gray,Jane, AU - Hannon,Greg, AU - Brookes,Karen, AU - Canna,Laura, AU - Cruz,Isabel, AU - Dempsey,Katie, AU - Elmer,Anne, AU - Escoffery,Naidine, AU - Fuller,Stewart, AU - Jones,Heather, AU - Ribeiro,Carla, AU - Saunders,Caroline, AU - Wright,Angela, AU - Nyagumbo,Rutendo, AU - Roberts,Anne, AU - Bucke,Ashlea, AU - Hargreaves,Simone, AU - Johnson,Danielle, AU - Narcorda,Aileen, AU - Read,Debbie, AU - Sparke,Christian, AU - Worboys,Lucy, AU - Lagadu,Kirsty, AU - Mactavous,Lenette, AU - Gould,Tim, AU - Raine,Tim, AU - Shaw,Ashley, AU - Mather,Claire, AU - Ramenatte,Nicola, AU - Vallier,Anne-Laure, AU - Kasanicki,Mary, AU - Eames,Penelope-Jane, AU - McNicholas,Chris, AU - Thake,Lisa, AU - Bartholomew,Neil, AU - Brown,Nick, AU - Curran,Martin, AU - Parmar,Surendra, AU - Zhang,Hongyi, AU - Bowring,Ailsa, AU - Ferris,Mark, AU - Martell,Geraldine, AU - Quinnell,Natalie, AU - Wright,Giles, AU - Wright,Jo, AU - Murphy,Helen, AU - Dunmore,Benjamin J, AU - Legchenko,Ekaterina, AU - Gräf,Stefan, AU - Huang,Christopher, AU - Hodgson,Josh, AU - Hunter,Kelvin, AU - Martin,Jennifer, AU - Mescia,Federica, AU - ODonnell,Ciara, AU - Pointon,Linda, AU - Shih,Joy, AU - Sutcliffe,Rachel, AU - Tilly,Tobias, AU - Tong,Zhen, AU - Treacy,Carmen, AU - Wood,Jennifer, AU - Bergamaschi,Laura, AU - Betancourt,Ariana, AU - Bowyer,Georgie, AU - De Sa,Aloka, AU - Epping,Maddie, AU - Hinch,Andrew, AU - Huhn,Oisin, AU - Jarvis,Isobel, AU - Lewis,Daniel, AU - Marsden,Joe, AU - McCallum,Simon, AU - Nice,Francescsa, AU - Omarjee,Ommar, AU - Perera,Marianne, AU - Romashova,Nika, AU - Strezlecki,Mateusz, AU - Yarkoni,Natalia Savoinykh, AU - Turner,Lori, AU - Bailey,Barrie, AU - Chaudhry,Afzal, AU - Doughton,Rachel, AU - Workman,Chris, AU - Trotter,Caroline, AU - David,William, AU - Jiménez,Cordova, AU - Levy,Jack, AU - Samad,Fatima Nb, AU - Curran,Martin D, AU - Fuller,Stewart, AU - Chaudhry,Afzal, AU - Shaw,Ashley, AU - Bradley,John R, AU - Hannon,Gregory J, AU - Goodfellow,Ian G, AU - Dougan,Gordon, AU - Smith,Kenneth Gc, AU - Lehner,Paul J, AU - Wright,Giles, AU - Matheson,Nicholas J, AU - Baker,Stephen, AU - Weekes,Michael P, Y1 - 2020/06/19/ PY - 2020/05/28/received PY - 2020/06/19/accepted PY - 2020/6/20/pubmed PY - 2020/7/14/medline PY - 2020/6/20/entrez KW - COVID-19 KW - SARS-CoV-2 KW - emerging pathogens KW - epidemiology KW - global health KW - human KW - human biology KW - infectious disease KW - medicine KW - occupational health KW - virology JF - eLife JO - Elife VL - 9 N2 - Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus disease 2019 (COVID-19) also tested positive for SARS-CoV-2 (Rivett et al., 2020). Here, we show that the proportion of both asymptomatic and symptomatic HCWs testing positive for SARS-CoV-2 rapidly declined to near-zero between 25th April and 24th May 2020, corresponding to a decline in patient admissions with COVID-19 during the ongoing UK 'lockdown'. These data demonstrate how infection prevention and control measures including staff testing may help prevent hospitals from becoming independent 'hubs' of SARS-CoV-2 transmission, and illustrate how, with appropriate precautions, organizations in other sectors may be able to resume on-site work safely. SN - 2050-084X UR - https://www.unboundmedicine.com/medline/citation/32558644/Effective_control_of_SARS_CoV_2_transmission_between_healthcare_workers_during_a_period_of_diminished_community_prevalence_of_COVID_19_ L2 - https://doi.org/10.7554/eLife.59391 DB - PRIME DP - Unbound Medicine ER -