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Cannabis extract for the treatment of painful tonic spasms in a patient with neuromyelitis optica spectrum disorder: A case report.
Mult Scler Relat Disord. 2020 Jun 16; 44:102278.MS

Abstract

Painful tonic spasm (PTS) is a common yet debilitating symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), especially those with longitudinally extensive transverse myelitis. Although carbamazepine is an effective treatment, it poses the risk of severe adverse reactions, such as Steven-Johnson syndrome (SJS). In this case report, we describe an NMOSD patient with severe PTS suffering from carbamazepine-induced SJS who responded well to cannabis extract. Since cannabinoids can ameliorate spasticity in an experimental autoimmune encephalomyelitis model through cannabinoid 1 (CB1) receptor activation, cannabis extract which includes delta-9-tetrahydrocannabinol (THC) is a potential treatment option for PTS in NMOSD patients.

Authors+Show Affiliations

Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand. Electronic address: nanthaya90@gmail.com.Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand; Siriraj Neuroimmunology Center, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand; Bumrungrad International Hospital, Bangkok, 10110, Thailand. Electronic address: siritho@yahoo.com.Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand; Siriraj Neuroimmunology Center, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand. Electronic address: naraporn.pra@mahidol.ac.th.Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand; Siriraj Neuroimmunology Center, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand. Electronic address: jiraporn.jit@mahidol.ac.th.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32559701

Citation

Tisavipat, Nanthaya, et al. "Cannabis Extract for the Treatment of Painful Tonic Spasms in a Patient With Neuromyelitis Optica Spectrum Disorder: a Case Report." Multiple Sclerosis and Related Disorders, vol. 44, 2020, p. 102278.
Tisavipat N, Siritho S, Prayoonwiwat N, et al. Cannabis extract for the treatment of painful tonic spasms in a patient with neuromyelitis optica spectrum disorder: A case report. Mult Scler Relat Disord. 2020;44:102278.
Tisavipat, N., Siritho, S., Prayoonwiwat, N., & Jitprapaikulsan, J. (2020). Cannabis extract for the treatment of painful tonic spasms in a patient with neuromyelitis optica spectrum disorder: A case report. Multiple Sclerosis and Related Disorders, 44, 102278. https://doi.org/10.1016/j.msard.2020.102278
Tisavipat N, et al. Cannabis Extract for the Treatment of Painful Tonic Spasms in a Patient With Neuromyelitis Optica Spectrum Disorder: a Case Report. Mult Scler Relat Disord. 2020 Jun 16;44:102278. PubMed PMID: 32559701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabis extract for the treatment of painful tonic spasms in a patient with neuromyelitis optica spectrum disorder: A case report. AU - Tisavipat,Nanthaya, AU - Siritho,Sasitorn, AU - Prayoonwiwat,Naraporn, AU - Jitprapaikulsan,Jiraporn, Y1 - 2020/06/16/ PY - 2020/04/16/received PY - 2020/05/27/revised PY - 2020/06/07/accepted PY - 2020/6/20/pubmed PY - 2020/6/20/medline PY - 2020/6/20/entrez KW - Cannabis KW - Carbamazepine KW - Longitudinally extensive transverse myelitis KW - Neuromyelitis optica (NMO) KW - Painful tonic spasm KW - THC SP - 102278 EP - 102278 JF - Multiple sclerosis and related disorders JO - Mult Scler Relat Disord VL - 44 N2 - Painful tonic spasm (PTS) is a common yet debilitating symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), especially those with longitudinally extensive transverse myelitis. Although carbamazepine is an effective treatment, it poses the risk of severe adverse reactions, such as Steven-Johnson syndrome (SJS). In this case report, we describe an NMOSD patient with severe PTS suffering from carbamazepine-induced SJS who responded well to cannabis extract. Since cannabinoids can ameliorate spasticity in an experimental autoimmune encephalomyelitis model through cannabinoid 1 (CB1) receptor activation, cannabis extract which includes delta-9-tetrahydrocannabinol (THC) is a potential treatment option for PTS in NMOSD patients. SN - 2211-0356 UR - https://www.unboundmedicine.com/medline/citation/32559701/Cannabis_extract_for_the_treatment_of_painful_tonic_spasms_in_a_patient_with_neuromyelitis_optica_spectrum_disorder:_A_case_report L2 - https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(20)30354-0 DB - PRIME DP - Unbound Medicine ER -
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