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Biogenic Silver and Zero-Valent Iron Nanoparticles by Feijoa: Biosynthesis, Characterization, Cytotoxic, Antibacterial and Antioxidant Activities.
Anticancer Agents Med Chem. 2020; 20(14):1673-1687.AA

Abstract

BACKGROUND AND PURPOSE

Green nanotechnology is an interesting method for the synthesis of functional nanoparticles. Because of their wide application, they have set up great attention in recent years.

OBJECTIVE

The present research examines the green synthesis of Ag and zero-valent iron nanoparticles (AgNPs, ZVINPs) by Feijoa sellowiana fruit extract. In this synthesis, no stabilizers or surfactants were applied.

METHODS

Eco-friendly synthesis of Iron and biogenic synthesis of Ag nanoparticles were accomplished by controlling critical parameters such as concentration, incubation period and temperature. Scanning Electron Microscopy (SEM), Transmission Electron Microscope (TEM), Energy-Dispersive X-ray Spectroscopy (EDS), Fourier-Transform Infrared (FT-IR) spectroscopy, X-ray Diffraction analysis (XRD), Dynamic Light Scattering (DLS) and UV-Vis were applied to characterize NPs. The cytotoxicity of NPs was investigated in two cell lines, MCF-7 (breast cancer) and AGS (human gastric carcinoma). A high-performance liquid chromatography (HPLC) analysis was also performed for characterization of phenolic acids in the extract.

RESULTS

Both NPs displayed powerful anticancer activities against two tumor cell lines with little effect on BEAS-2B normal cells. Synthesized AgNPs and ZVINPs inhibited the growth of all selected bacteria. Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumonia, Staphylococcus aureus, Enterococcus faecalis, Acinetobacter baumannii and Escherichia coli have been studied in two stages. We initially examined the ATCCs followed by clinical strain isolation. Based on the results from resistant strains, we showed that nanoparticles were superior to conventional antibiotics. DPPH (diphenyl-1-picrylhydrazyl) free radical scavenging assay and iron chelating activity were used for the determination of antioxidant properties. Results showed a high antioxidant activity of scavenging free radicals for ZVINPs and powerful iron-chelating activity for AgNPs. Based on the HPLC data, catechin was the major phenolic compound in the extract.

CONCLUSION

Our synthesized nanoparticles displayed potent cytotoxic, antibacterial and antioxidant activities.

Authors+Show Affiliations

Depatment of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.Depatment of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.Department of Basic Sciences, Sari University of Agricultural Sciences and Natural Resources, Sari, Iran.Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran.Molecular and Cell Biology Research Center, Hemoglobinopathy Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Depatment of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.Molecular and Cell Biology Research Center, Hemoglobinopathy Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Molecular and Cell Biology Research Center, Hemoglobinopathy Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32560617

Citation

Hashemi, Zahra, et al. "Biogenic Silver and Zero-Valent Iron Nanoparticles By Feijoa: Biosynthesis, Characterization, Cytotoxic, Antibacterial and Antioxidant Activities." Anti-cancer Agents in Medicinal Chemistry, vol. 20, no. 14, 2020, pp. 1673-1687.
Hashemi Z, Ebrahimzadeh MA, Biparva P, et al. Biogenic Silver and Zero-Valent Iron Nanoparticles by Feijoa: Biosynthesis, Characterization, Cytotoxic, Antibacterial and Antioxidant Activities. Anticancer Agents Med Chem. 2020;20(14):1673-1687.
Hashemi, Z., Ebrahimzadeh, M. A., Biparva, P., Mortazavi-Derazkola, S., Goli, H. R., Sadeghian, F., Kardan, M., & Rafiei, A. (2020). Biogenic Silver and Zero-Valent Iron Nanoparticles by Feijoa: Biosynthesis, Characterization, Cytotoxic, Antibacterial and Antioxidant Activities. Anti-cancer Agents in Medicinal Chemistry, 20(14), 1673-1687. https://doi.org/10.2174/1871520620666200619165910
Hashemi Z, et al. Biogenic Silver and Zero-Valent Iron Nanoparticles By Feijoa: Biosynthesis, Characterization, Cytotoxic, Antibacterial and Antioxidant Activities. Anticancer Agents Med Chem. 2020;20(14):1673-1687. PubMed PMID: 32560617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biogenic Silver and Zero-Valent Iron Nanoparticles by Feijoa: Biosynthesis, Characterization, Cytotoxic, Antibacterial and Antioxidant Activities. AU - Hashemi,Zahra, AU - Ebrahimzadeh,Mohammad Ali, AU - Biparva,Pourya, AU - Mortazavi-Derazkola,Sobhan, AU - Goli,Hamid Reza, AU - Sadeghian,Fereshteh, AU - Kardan,Mostafa, AU - Rafiei,Alireza, PY - 2019/09/19/received PY - 2020/03/06/revised PY - 2020/03/06/accepted PY - 2020/6/21/pubmed PY - 2021/6/3/medline PY - 2020/6/21/entrez KW - Ag nanoparticles KW - anticancer KW - antimicrobial KW - antioxidant KW - green synthesis KW - zero-valent iron nanoparticles SP - 1673 EP - 1687 JF - Anti-cancer agents in medicinal chemistry JO - Anticancer Agents Med Chem VL - 20 IS - 14 N2 - BACKGROUND AND PURPOSE: Green nanotechnology is an interesting method for the synthesis of functional nanoparticles. Because of their wide application, they have set up great attention in recent years. OBJECTIVE: The present research examines the green synthesis of Ag and zero-valent iron nanoparticles (AgNPs, ZVINPs) by Feijoa sellowiana fruit extract. In this synthesis, no stabilizers or surfactants were applied. METHODS: Eco-friendly synthesis of Iron and biogenic synthesis of Ag nanoparticles were accomplished by controlling critical parameters such as concentration, incubation period and temperature. Scanning Electron Microscopy (SEM), Transmission Electron Microscope (TEM), Energy-Dispersive X-ray Spectroscopy (EDS), Fourier-Transform Infrared (FT-IR) spectroscopy, X-ray Diffraction analysis (XRD), Dynamic Light Scattering (DLS) and UV-Vis were applied to characterize NPs. The cytotoxicity of NPs was investigated in two cell lines, MCF-7 (breast cancer) and AGS (human gastric carcinoma). A high-performance liquid chromatography (HPLC) analysis was also performed for characterization of phenolic acids in the extract. RESULTS: Both NPs displayed powerful anticancer activities against two tumor cell lines with little effect on BEAS-2B normal cells. Synthesized AgNPs and ZVINPs inhibited the growth of all selected bacteria. Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumonia, Staphylococcus aureus, Enterococcus faecalis, Acinetobacter baumannii and Escherichia coli have been studied in two stages. We initially examined the ATCCs followed by clinical strain isolation. Based on the results from resistant strains, we showed that nanoparticles were superior to conventional antibiotics. DPPH (diphenyl-1-picrylhydrazyl) free radical scavenging assay and iron chelating activity were used for the determination of antioxidant properties. Results showed a high antioxidant activity of scavenging free radicals for ZVINPs and powerful iron-chelating activity for AgNPs. Based on the HPLC data, catechin was the major phenolic compound in the extract. CONCLUSION: Our synthesized nanoparticles displayed potent cytotoxic, antibacterial and antioxidant activities. SN - 1875-5992 UR - https://www.unboundmedicine.com/medline/citation/32560617/Biogenic_Silver_and_Zero_Valent_Iron_Nanoparticles_by_Feijoa:_Biosynthesis_Characterization_Cytotoxic_Antibacterial_and_Antioxidant_Activities_ L2 - https://www.eurekaselect.com/182952/article DB - PRIME DP - Unbound Medicine ER -