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Olfactory and gustatory dysfunctions in COVID-19 patients: A systematic review and meta-analysis.
Asian Pac J Allergy Immunol. 2020 Sep; 38(3):162-169.AP

Abstract

Olfactory and gustatory dysfunctions (OGD) are pathognomonic symptoms in patients with Coronavirus Disease 2019 (COVID-19). This study reviews the associations of OGD with COVID-19 which will be useful for early diagnosis and self-isolation. Systematic searches of PubMed, Ovid Medline, Scopus, and EMBASE electronic databases were performed. Studies reporting OGD in COVID-19 patients were included. Data were pooled for meta-analysis. The outcomes were odds ratios (OR) of OGD in COVID-19 patients. Proportions of smell and/or taste dysfunctions in the COVID-19 patients were assessed. Fourteen studies (21,515 participants, age 49.12 years, 26% male) were included. The OR of olfactory and/or gustatory dysfunctions in COVID-19 patients were 11.26 (95% confidence interval (CI) 5.41 to 23.4) when compared with acute respiratory infection (ARI) without detectable virus and 6.46 (95% CI 2.79 to 14.97) in patients with other respiratory viruses. The OR of olfactory dysfunction in COVID-19 patients were 11.67 (95% CI 6.43 to 21.17) when compared with the ARI patients without detectable virus and 4.17 (95% CI 1.34 to 12.98) with other respiratory viruses. The OR of gustatory dysfunction in COVID-19 patients were 12.70 (95% CI 7.9 to 20.44) when compared with the ARI patients without detectable virus and 4.94 (95%CI 1.59 to 15.31) with other respiratory viruses. Fifty percent (95% CI 36.7 to 63.3%) of COVID-19 patients had olfactory and/or gustatory dysfunctions. In summary, there are associations between OGD and COVID-19 patients. Patients presenting with ARI should be assessed for olfactory and gustatory functions.

Authors+Show Affiliations

Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Endoscopic Nasal and Sinus Surgery Excellence Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Department of Otolaryngology, Hue University of Medicine and Pharmacy, Hue University, Vietnam.Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Endoscopic Nasal and Sinus Surgery Excellence Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Endoscopic Nasal and Sinus Surgery Excellence Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Endoscopic Nasal and Sinus Surgery Excellence Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Endoscopic Nasal and Sinus Surgery Excellence Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Endoscopic Nasal and Sinus Surgery Excellence Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

32563232

Citation

Hoang, Minh P., et al. "Olfactory and Gustatory Dysfunctions in COVID-19 Patients: a Systematic Review and Meta-analysis." Asian Pacific Journal of Allergy and Immunology, vol. 38, no. 3, 2020, pp. 162-169.
Hoang MP, Kanjanaumporn J, Aeumjaturapat S, et al. Olfactory and gustatory dysfunctions in COVID-19 patients: A systematic review and meta-analysis. Asian Pac J Allergy Immunol. 2020;38(3):162-169.
Hoang, M. P., Kanjanaumporn, J., Aeumjaturapat, S., Chusakul, S., Seresirikachorn, K., & Snidvongs, K. (2020). Olfactory and gustatory dysfunctions in COVID-19 patients: A systematic review and meta-analysis. Asian Pacific Journal of Allergy and Immunology, 38(3), 162-169. https://doi.org/10.12932/AP-210520-0853
Hoang MP, et al. Olfactory and Gustatory Dysfunctions in COVID-19 Patients: a Systematic Review and Meta-analysis. Asian Pac J Allergy Immunol. 2020;38(3):162-169. PubMed PMID: 32563232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olfactory and gustatory dysfunctions in COVID-19 patients: A systematic review and meta-analysis. AU - Hoang,Minh P, AU - Kanjanaumporn,Jesada, AU - Aeumjaturapat,Songklot, AU - Chusakul,Supinda, AU - Seresirikachorn,Kachorn, AU - Snidvongs,Kornkiat, PY - 2020/6/22/pubmed PY - 2020/10/8/medline PY - 2020/6/22/entrez SP - 162 EP - 169 JF - Asian Pacific journal of allergy and immunology JO - Asian Pac J Allergy Immunol VL - 38 IS - 3 N2 - Olfactory and gustatory dysfunctions (OGD) are pathognomonic symptoms in patients with Coronavirus Disease 2019 (COVID-19). This study reviews the associations of OGD with COVID-19 which will be useful for early diagnosis and self-isolation. Systematic searches of PubMed, Ovid Medline, Scopus, and EMBASE electronic databases were performed. Studies reporting OGD in COVID-19 patients were included. Data were pooled for meta-analysis. The outcomes were odds ratios (OR) of OGD in COVID-19 patients. Proportions of smell and/or taste dysfunctions in the COVID-19 patients were assessed. Fourteen studies (21,515 participants, age 49.12 years, 26% male) were included. The OR of olfactory and/or gustatory dysfunctions in COVID-19 patients were 11.26 (95% confidence interval (CI) 5.41 to 23.4) when compared with acute respiratory infection (ARI) without detectable virus and 6.46 (95% CI 2.79 to 14.97) in patients with other respiratory viruses. The OR of olfactory dysfunction in COVID-19 patients were 11.67 (95% CI 6.43 to 21.17) when compared with the ARI patients without detectable virus and 4.17 (95% CI 1.34 to 12.98) with other respiratory viruses. The OR of gustatory dysfunction in COVID-19 patients were 12.70 (95% CI 7.9 to 20.44) when compared with the ARI patients without detectable virus and 4.94 (95%CI 1.59 to 15.31) with other respiratory viruses. Fifty percent (95% CI 36.7 to 63.3%) of COVID-19 patients had olfactory and/or gustatory dysfunctions. In summary, there are associations between OGD and COVID-19 patients. Patients presenting with ARI should be assessed for olfactory and gustatory functions. SN - 0125-877X UR - https://www.unboundmedicine.com/medline/citation/32563232/Olfactory_and_gustatory_dysfunctions_in_COVID_19_patients:_A_systematic_review_and_meta_analysis_ L2 - http://apjai-journal.org/wp-content/uploads/2020/09/3.pdf DB - PRIME DP - Unbound Medicine ER -