Tags

Type your tag names separated by a space and hit enter

[Early-onset melanoma (congenital, neonatal, infantile): A systematic review of literature cases].
Ann Dermatol Venereol. 2020 Jun 17 [Online ahead of print]AD

Abstract

INTRODUCTION

Neonatal and infantile malignant melanoma is rare. It may be difficult to diagnose and often carries a poor prognosis.

MATERIAL AND METHODS

We decided to review the data on congenital, neonatal and infantile malignant melanomas in order to understand their presentation (clinical, histological, molecular), diagnosis, management and outcomes. We performed a literature search of all cases of early-onset melanoma published in PubMed from its inception to March 2019 using the following keywords: "malignant melanoma" OR "melanoma" OR "pigmented nevus" OR "malignant pigmented" AND "infantile" OR "congenital" OR "children" OR "childhood" OR "infancy" OR "neonatal". Congenital melanoma associated with maternal-foetal transmission was not included in the study.

RESULTS

Sixty-five articles were selected and 85 cases were included in the study. Most patients were male (sex ratio: 1.6). The average age at diagnosis was 5.5 months (minimum-maximum: 0-24 months). The main site reported for congenital melanoma was the head-and-neck area and for neonatal and infantile melanoma the trunk. Half of all patients had a metastatic disease at the time of diagnosis. In metastatic cases, the prognosis was poor with the exception of patients undergoing complete excision of the tumour and metastases. The main treatment for cutaneous melanomas and operable metastasis was surgery, and secondarily, chemotherapy/immunotherapy.

CONCLUSION

Neonatal and infantile malignant melanoma are rarely reported and not well-documented. It is necessary to collect additional cases to improve our knowledge of this rare disease.

Authors+Show Affiliations

Service de dermatologie, CHU de Poitiers, université de Poitiers, hôpital Jean-Bernard, Poitiers, France; Service de dermatologie, centre de références de maladies rares de la peau et des muqueuses, CHU de Toulouse, université Paul Sabatier, hôpital Larrey, Toulouse, France. Electronic address: marie.masson-regnault@chu-poitiers.fr.Service de dermatologie, centre de références de maladies rares de la peau et des muqueuses, CHU de Toulouse, université Paul Sabatier, hôpital Larrey, Toulouse, France.Groupe hospitalier Necker-Enfants malades, service d'anatomopathologie, AP-HP, Paris, France.

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

32563535

Citation

Masson Regnault, M, et al. "[Early-onset Melanoma (congenital, Neonatal, Infantile): a Systematic Review of Literature Cases]." Annales De Dermatologie Et De Venereologie, 2020.
Masson Regnault M, Mazereeuw-Hautier J, Fraitag S. [Early-onset melanoma (congenital, neonatal, infantile): A systematic review of literature cases]. Ann Dermatol Venereol. 2020.
Masson Regnault, M., Mazereeuw-Hautier, J., & Fraitag, S. (2020). [Early-onset melanoma (congenital, neonatal, infantile): A systematic review of literature cases]. Annales De Dermatologie Et De Venereologie. https://doi.org/10.1016/j.annder.2020.05.001
Masson Regnault M, Mazereeuw-Hautier J, Fraitag S. [Early-onset Melanoma (congenital, Neonatal, Infantile): a Systematic Review of Literature Cases]. Ann Dermatol Venereol. 2020 Jun 17; PubMed PMID: 32563535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Early-onset melanoma (congenital, neonatal, infantile): A systematic review of literature cases]. AU - Masson Regnault,M, AU - Mazereeuw-Hautier,J, AU - Fraitag,S, Y1 - 2020/06/17/ PY - 2019/09/29/received PY - 2019/12/09/revised PY - 2020/05/11/accepted PY - 2020/6/22/pubmed PY - 2020/6/22/medline PY - 2020/6/22/entrez KW - Congenital melanoma KW - Giant congenital nevus KW - Infantile melanoma KW - Mélanome congénital KW - Mélanome du nourrisson KW - Mélanome du nouveau-né KW - Neonatal melanoma KW - Nævus congénital de grande taille JF - Annales de dermatologie et de venereologie JO - Ann Dermatol Venereol N2 - INTRODUCTION: Neonatal and infantile malignant melanoma is rare. It may be difficult to diagnose and often carries a poor prognosis. MATERIAL AND METHODS: We decided to review the data on congenital, neonatal and infantile malignant melanomas in order to understand their presentation (clinical, histological, molecular), diagnosis, management and outcomes. We performed a literature search of all cases of early-onset melanoma published in PubMed from its inception to March 2019 using the following keywords: "malignant melanoma" OR "melanoma" OR "pigmented nevus" OR "malignant pigmented" AND "infantile" OR "congenital" OR "children" OR "childhood" OR "infancy" OR "neonatal". Congenital melanoma associated with maternal-foetal transmission was not included in the study. RESULTS: Sixty-five articles were selected and 85 cases were included in the study. Most patients were male (sex ratio: 1.6). The average age at diagnosis was 5.5 months (minimum-maximum: 0-24 months). The main site reported for congenital melanoma was the head-and-neck area and for neonatal and infantile melanoma the trunk. Half of all patients had a metastatic disease at the time of diagnosis. In metastatic cases, the prognosis was poor with the exception of patients undergoing complete excision of the tumour and metastases. The main treatment for cutaneous melanomas and operable metastasis was surgery, and secondarily, chemotherapy/immunotherapy. CONCLUSION: Neonatal and infantile malignant melanoma are rarely reported and not well-documented. It is necessary to collect additional cases to improve our knowledge of this rare disease. SN - 0151-9638 UR - https://www.unboundmedicine.com/medline/citation/32563535/[Early-onset_melanoma_(congenital,_neonatal,_infantile):_A_systematic_review_of_literature_cases] L2 - https://linkinghub.elsevier.com/retrieve/pii/S0151-9638(20)30238-6 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.