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Clinical characteristics of the coronavirus disease 2019 (COVID-19) outbreak on a cruise ship.
J Infect Chemother. 2020 Nov; 26(11):1177-1180.JI

Abstract

BACKGROUND

A large COVID-19 outbreak occurred on the cruise ship Diamond Princess in February 2020. Little information has been reported about the clinical characteristics of the patients.

METHODS

This single-center, retrospective, observational study was conducted in Yokohama, Japan. We included symptomatic patients who were infected on the ship and admitted to our hospital between 5 and 19 February 2020. All the cases were confirmed with SARS-CoV-2 infection by polymerase chain reaction (PCR).

RESULTS

We confirmed 17 cases. The average age was 69 years; 10 patients were Asian and 7 were Caucasian. Eleven patients had one or more chronic diseases. The major symptoms were cough and fever. Chest computed tomography (CT) scans found bilateral ground-glass opacities predominantly in the peripheral area, which were similar to reports from cases in China. C-reactive protein (CRP) levels were higher in severe and critical cases than in mild to moderate cases. The moderate to severe cases reached symptomatic resolution; one of the three critical cases resulted in death due to multiple organ failure. SARS-CoV-2 was detected by PCR at an average of 7 days after symptomatic resolution.

CONCLUSIONS

Cough and fever, increased blood CRP levels, and CT findings of bilateral ground-glass opacities predominantly in the peripheral lung were characteristic of the COVID-19 cases in this study. These findings were compatible with those of previous reports.

Authors+Show Affiliations

Department of Infectious Disease, Yokohama Municipal Citizen's Hospital, Japan. Electronic address: yu10-yoshimura@city.yokohama.jp.Department of Infectious Disease, Yokohama Municipal Citizen's Hospital, Japan.Department of Infectious Disease, Yokohama Municipal Citizen's Hospital, Japan.Department of Infectious Disease, Yokohama Municipal Citizen's Hospital, Japan.Department of Infectious Disease, Yokohama Municipal Citizen's Hospital, Japan.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

32565152

Citation

Yoshimura, Yukihiro, et al. "Clinical Characteristics of the Coronavirus Disease 2019 (COVID-19) Outbreak On a Cruise Ship." Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, vol. 26, no. 11, 2020, pp. 1177-1180.
Yoshimura Y, Sasaki H, Horiuchi H, et al. Clinical characteristics of the coronavirus disease 2019 (COVID-19) outbreak on a cruise ship. J Infect Chemother. 2020;26(11):1177-1180.
Yoshimura, Y., Sasaki, H., Horiuchi, H., Miyata, N., & Tachikawa, N. (2020). Clinical characteristics of the coronavirus disease 2019 (COVID-19) outbreak on a cruise ship. Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, 26(11), 1177-1180. https://doi.org/10.1016/j.jiac.2020.06.010
Yoshimura Y, et al. Clinical Characteristics of the Coronavirus Disease 2019 (COVID-19) Outbreak On a Cruise Ship. J Infect Chemother. 2020;26(11):1177-1180. PubMed PMID: 32565152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of the coronavirus disease 2019 (COVID-19) outbreak on a cruise ship. AU - Yoshimura,Yukihiro, AU - Sasaki,Hiroaki, AU - Horiuchi,Hiroshi, AU - Miyata,Nobuyuki, AU - Tachikawa,Natsuo, Y1 - 2020/06/12/ PY - 2020/03/12/received PY - 2020/06/04/revised PY - 2020/06/07/accepted PY - 2020/6/23/pubmed PY - 2020/9/15/medline PY - 2020/6/23/entrez KW - COVID-19 KW - Coronavirus infection KW - Cruise SP - 1177 EP - 1180 JF - Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy JO - J Infect Chemother VL - 26 IS - 11 N2 - BACKGROUND: A large COVID-19 outbreak occurred on the cruise ship Diamond Princess in February 2020. Little information has been reported about the clinical characteristics of the patients. METHODS: This single-center, retrospective, observational study was conducted in Yokohama, Japan. We included symptomatic patients who were infected on the ship and admitted to our hospital between 5 and 19 February 2020. All the cases were confirmed with SARS-CoV-2 infection by polymerase chain reaction (PCR). RESULTS: We confirmed 17 cases. The average age was 69 years; 10 patients were Asian and 7 were Caucasian. Eleven patients had one or more chronic diseases. The major symptoms were cough and fever. Chest computed tomography (CT) scans found bilateral ground-glass opacities predominantly in the peripheral area, which were similar to reports from cases in China. C-reactive protein (CRP) levels were higher in severe and critical cases than in mild to moderate cases. The moderate to severe cases reached symptomatic resolution; one of the three critical cases resulted in death due to multiple organ failure. SARS-CoV-2 was detected by PCR at an average of 7 days after symptomatic resolution. CONCLUSIONS: Cough and fever, increased blood CRP levels, and CT findings of bilateral ground-glass opacities predominantly in the peripheral lung were characteristic of the COVID-19 cases in this study. These findings were compatible with those of previous reports. SN - 1437-7780 UR - https://www.unboundmedicine.com/medline/citation/32565152/Clinical_characteristics_of_the_coronavirus_disease_2019__COVID_19__outbreak_on_a_cruise_ship_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1341-321X(20)30196-3 DB - PRIME DP - Unbound Medicine ER -