A Systematic Review of Cases of Acute Respiratory Distress Syndrome in the Coronavirus Disease 2019 Pandemic.
Cureus. 2020 May 18; 12(5):e8188.C

Abstract

The outbreak of coronavirus disease 2019 (COVID-19) was declared a global pandemic after it spread to 213 countries and has the highest total number of cases worldwide. About 80% of COVID-19 infections are mild or asymptomatic and never require hospitalization but about 5% of patients become critically ill and develop acute respiratory distress syndrome (ARDS). The widely used management for ARDS in COVID-19 has been in line with the standard approach, but the need to adjust the treatment protocols has been questioned based on the reports of higher mortality risk among those requiring mechanical ventilation. Treatment options for this widespread disease are limited and there are no definitive therapies or vaccines until now. Although some antimalarial and antiviral drugs may prove effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), their safety and efficacy are still under clinical trials. We conducted a systematic review of case reports on ARDS in SARS-CoV-2 infection to summarize the clinical presentation, laboratory and chest imaging findings, management protocols, and outcome of ARDS in COVID-19-positive patients. We need more data and established studies for the effective management of the novel SARS-CoV-2 and to reduce mortality in high-risk patients.

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Authors+Show Affiliations

Baksh M

Internal Medicine, Dr. Nandamuri Taraka Rama Rao University of Health Sciences, Vijayawada, IND.

Ravat V

Internal Medicine, Krishna Institute of Medical Sciences, Karad, IND.

Zaidi A

Medicine, Dow University of Health Sciences, Karachi, PAK.

Patel RS

Psychiatry, Griffin Memorial Hospital, Norman, USA.

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

32566429

Citation

Baksh, Mizba, et al. "A Systematic Review of Cases of Acute Respiratory Distress Syndrome in the Coronavirus Disease 2019 Pandemic." Cureus, vol. 12, no. 5, 2020, pp. e8188.

Baksh M, Ravat V, Zaidi A, et al. A Systematic Review of Cases of Acute Respiratory Distress Syndrome in the Coronavirus Disease 2019 Pandemic. Cureus. 2020;12(5):e8188.

Baksh, M., Ravat, V., Zaidi, A., & Patel, R. S. (2020). A Systematic Review of Cases of Acute Respiratory Distress Syndrome in the Coronavirus Disease 2019 Pandemic. Cureus, 12(5), e8188. https://doi.org/10.7759/cureus.8188

Baksh M, et al. A Systematic Review of Cases of Acute Respiratory Distress Syndrome in the Coronavirus Disease 2019 Pandemic. Cureus. 2020 May 18;12(5):e8188. PubMed PMID: 32566429.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - A Systematic Review of Cases of Acute Respiratory Distress Syndrome in the Coronavirus Disease 2019 Pandemic. AU - Baksh,Mizba, AU - Ravat,Virendrasinh, AU - Zaidi,Annam, AU - Patel,Rikinkumar S, Y1 - 2020/05/18/ PY - 2020/6/23/entrez PY - 2020/6/23/pubmed PY - 2020/6/23/medline KW - corona pandemic KW - hospital epidemiology KW - mortality KW - novel corona virus KW - sars-cov-2 (severe acute respiratory syndrome coronavirus-2) KW - severe acute respiratory syndrome coronavirus 2 SP - e8188 EP - e8188 JF - Cureus JO - Cureus VL - 12 IS - 5 N2 - The outbreak of coronavirus disease 2019 (COVID-19) was declared a global pandemic after it spread to 213 countries and has the highest total number of cases worldwide. About 80% of COVID-19 infections are mild or asymptomatic and never require hospitalization but about 5% of patients become critically ill and develop acute respiratory distress syndrome (ARDS). The widely used management for ARDS in COVID-19 has been in line with the standard approach, but the need to adjust the treatment protocols has been questioned based on the reports of higher mortality risk among those requiring mechanical ventilation. Treatment options for this widespread disease are limited and there are no definitive therapies or vaccines until now. Although some antimalarial and antiviral drugs may prove effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), their safety and efficacy are still under clinical trials. We conducted a systematic review of case reports on ARDS in SARS-CoV-2 infection to summarize the clinical presentation, laboratory and chest imaging findings, management protocols, and outcome of ARDS in COVID-19-positive patients. We need more data and established studies for the effective management of the novel SARS-CoV-2 and to reduce mortality in high-risk patients. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/32566429/A_Systematic_Review_of_Cases_of_Acute_Respiratory_Distress_Syndrome_in_the_Coronavirus_Disease_2019_Pandemic_ DB - PRIME DP - Unbound Medicine ER -

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A Systematic Review of Cases of Acute Respiratory Distress Syndrome in the Coronavirus Disease 2019 Pandemic.Cureus. 2020 May 18; 12(5):e8188.C