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Photon-counting computed tomography of lanthanide contrast agents with a high-flux 330-μm-pitch cadmium zinc telluride detector in a table-top system.
J Med Imaging (Bellingham). 2020 May; 7(3):033502.JM

Abstract

Purpose:

We present photon-counting computed tomography (PCCT) imaging of contrast agent triplets similar in atomic number ( Z ) achieved with a high-flux cadmium zinc telluride (CZT) detector. Approach: The table-top PCCT imaging system included a 330-μm -pitch CZT detector of size 8  mm×24  mm2 capable of using six energy bins. Four 3D-printed 3-cm-diameter phantoms each contained seven 6-mm-diameter vials with water and low and high concentration solutions of various contrast agents. Lanthanum ( Z=57 ), gadolinium (Gd) ( Z=64 ), and lutetium ( Z=71 ) were imaged together and so were iodine ( Z=53 ), Gd, and holmium ( Z=67 ). Each phantom was imaged with 1-mm aluminum-filtered 120-kVp cone beam x rays to produce six energy-binned computed tomography (CT) images.

Results:

K -edge images were reconstructed using a weighted sum of six CT images, which distinguished each contrast agent with a root-mean-square error (RMSE) of <0.29% and 0.51% for the 0.5% and 5% concentrations, respectively. Minimal cross-contamination in each K -edge image was seen, with RMSE values <0.27% in vials with no contrast.

Conclusion:

This is the first preliminary demonstration of simultaneously imaging three similar Z contrast agents with a difference in Z as low as 3.

Authors+Show Affiliations

University of Victoria, Department of Physics and Astronomy, Victoria, British Columbia, Canada.University of Victoria, Department of Physics and Astronomy, Victoria, British Columbia, Canada.University of Victoria, Department of Physics and Astronomy, Victoria, British Columbia, Canada.University of Victoria, Department of Physics and Astronomy, Victoria, British Columbia, Canada.University of Victoria, Department of Chemistry, Victoria, British Columbia, Canada. University of Victoria, CAMTEC, Centre for Advanced Materials and Related Technologies, Victoria, British Columbia, Canada.University of Victoria, Department of Chemistry, Victoria, British Columbia, Canada. University of Victoria, CAMTEC, Centre for Advanced Materials and Related Technologies, Victoria, British Columbia, Canada.Redlen Technologies, Saanichton, British Columbia, Canada.University of Victoria, Department of Physics and Astronomy, Victoria, British Columbia, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32566695

Citation

Dunning, Chelsea A S., et al. "Photon-counting Computed Tomography of Lanthanide Contrast Agents With a High-flux 330-μm-pitch Cadmium Zinc Telluride Detector in a Table-top System." Journal of Medical Imaging (Bellingham, Wash.), vol. 7, no. 3, 2020, p. 033502.
Dunning CAS, O'Connell J, Robinson SM, et al. Photon-counting computed tomography of lanthanide contrast agents with a high-flux 330-μm-pitch cadmium zinc telluride detector in a table-top system. J Med Imaging (Bellingham). 2020;7(3):033502.
Dunning, C. A. S., O'Connell, J., Robinson, S. M., Murphy, K. J., Frencken, A. L., van Veggel, F. C. J. M., Iniewski, K., & Bazalova-Carter, M. (2020). Photon-counting computed tomography of lanthanide contrast agents with a high-flux 330-μm-pitch cadmium zinc telluride detector in a table-top system. Journal of Medical Imaging (Bellingham, Wash.), 7(3), 033502. https://doi.org/10.1117/1.JMI.7.3.033502
Dunning CAS, et al. Photon-counting Computed Tomography of Lanthanide Contrast Agents With a High-flux 330-μm-pitch Cadmium Zinc Telluride Detector in a Table-top System. J Med Imaging (Bellingham). 2020;7(3):033502. PubMed PMID: 32566695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photon-counting computed tomography of lanthanide contrast agents with a high-flux 330-μm-pitch cadmium zinc telluride detector in a table-top system. AU - Dunning,Chelsea A S, AU - O'Connell,Jericho, AU - Robinson,Spencer M, AU - Murphy,Kevin J, AU - Frencken,Adriaan L, AU - van Veggel,Frank C J M, AU - Iniewski,Kris, AU - Bazalova-Carter,Magdalena, Y1 - 2020/06/15/ PY - 2019/12/08/received PY - 2020/05/20/accepted PY - 2021/06/15/pmc-release PY - 2020/6/23/entrez PY - 2020/6/23/pubmed PY - 2020/6/23/medline KW - contrast agents KW - image reconstruction KW - lanthanides KW - multienergy computed tomography KW - photon-counting detectors SP - 033502 EP - 033502 JF - Journal of medical imaging (Bellingham, Wash.) JO - J Med Imaging (Bellingham) VL - 7 IS - 3 N2 - Purpose: We present photon-counting computed tomography (PCCT) imaging of contrast agent triplets similar in atomic number ( Z ) achieved with a high-flux cadmium zinc telluride (CZT) detector. Approach: The table-top PCCT imaging system included a 330-μm -pitch CZT detector of size 8  mm×24  mm2 capable of using six energy bins. Four 3D-printed 3-cm-diameter phantoms each contained seven 6-mm-diameter vials with water and low and high concentration solutions of various contrast agents. Lanthanum ( Z=57 ), gadolinium (Gd) ( Z=64 ), and lutetium ( Z=71 ) were imaged together and so were iodine ( Z=53 ), Gd, and holmium ( Z=67 ). Each phantom was imaged with 1-mm aluminum-filtered 120-kVp cone beam x rays to produce six energy-binned computed tomography (CT) images. Results:K -edge images were reconstructed using a weighted sum of six CT images, which distinguished each contrast agent with a root-mean-square error (RMSE) of <0.29% and 0.51% for the 0.5% and 5% concentrations, respectively. Minimal cross-contamination in each K -edge image was seen, with RMSE values <0.27% in vials with no contrast. Conclusion: This is the first preliminary demonstration of simultaneously imaging three similar Z contrast agents with a difference in Z as low as 3. SN - 2329-4302 UR - https://www.unboundmedicine.com/medline/citation/32566695/Photon-counting_computed_tomography_of_lanthanide_contrast_agents_with_a_high-flux_330-μm-pitch_cadmium_zinc_telluride_detector_in_a_table-top_system L2 - https://doi.org/10.1117/1.JMI.7.3.033502 DB - PRIME DP - Unbound Medicine ER -
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