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Evaluation of oxidative stress biomarkers and liver and renal functional parameters in patients during treatment a mental health unit to treat alcohol dependence.
Drug Chem Toxicol. 2020 Jun 22 [Online ahead of print]DC

Abstract

Alcohol dependence is one of the main reasons for inpatient admission to psychiatric hospitals. The abuse of this chemical substance can cause modifications in our organism and among them, variations in the oxidative stress parameters. Therefore, the aim of this study is to evaluate patients admitted to a psychiatric hospital unit to treat alcohol dependence, comparing oxidative stress, renal and hepatic function parameters from the moment of admission to those obtained at discharge. Hepatic function was verified through gamma-glutamyl-transferase (GGT), alkaline-phosphatase (ALP), aspartate-aminotransferase (AST) and alanine-aminotransferase (ALT) activity measurements. Urea and creatinine serum levels were measured for kidney function evaluation. Oxidative stress was evaluated by superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), ferric reducing antioxidant power (FRAP) and malondialdehyde (MDA). Medications used during hospital stay were record and their influence over the measured parameters analyzed. Twenty-eight patients (82% male, 44 ± 13 years old) were included in this study. A significant increase in BMI of patients after the period of hospitalization could be observed. There were reductions in creatinine, AST, ALT, GGT and ALP serum levels. SOD levels were lower at discharge, while GPx and FRAP presented higher levels. Chlorpromazine use showed influence over some hepatic function markers (ALT, GGT and ALP) and oxidative stress parameters (CAT and GPx); while carbamazepine use influenced GGT and FRAP. Patients on alcohol dependence treatment had significant improvements of renal and hepatic function parameters and higher GPx and FRAP values after the hospitalization period, which indicates reversion of alcohol effects over oxidative stress parameters.

Authors+Show Affiliations

Graduate Program on Toxicology and Analytical Toxicology, Feevale University, Novo Hamburgo, Brazil. University Pharmacy, Feevale University, Novo Hamburgo, Brazil.University Pharmacy, Feevale University, Novo Hamburgo, Brazil.Graduate Program on Toxicology and Analytical Toxicology, Feevale University, Novo Hamburgo, Brazil. Laboratory of Analytical Toxicology, Feevale University, Novo Hamburgo, Brazil.Graduate Program on Toxicology and Analytical Toxicology, Feevale University, Novo Hamburgo, Brazil. Laboratory of Analytical Toxicology, Feevale University, Novo Hamburgo, Brazil.Graduate Program on Toxicology and Analytical Toxicology, Feevale University, Novo Hamburgo, Brazil. University Pharmacy, Feevale University, Novo Hamburgo, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32567384

Citation

Dries, Samuel Selbach, et al. "Evaluation of Oxidative Stress Biomarkers and Liver and Renal Functional Parameters in Patients During Treatment a Mental Health Unit to Treat Alcohol Dependence." Drug and Chemical Toxicology, 2020, pp. 1-7.
Dries SS, Seibert BS, Bastiani MF, et al. Evaluation of oxidative stress biomarkers and liver and renal functional parameters in patients during treatment a mental health unit to treat alcohol dependence. Drug Chem Toxicol. 2020.
Dries, S. S., Seibert, B. S., Bastiani, M. F., Linden, R., & Perassolo, M. S. (2020). Evaluation of oxidative stress biomarkers and liver and renal functional parameters in patients during treatment a mental health unit to treat alcohol dependence. Drug and Chemical Toxicology, 1-7. https://doi.org/10.1080/01480545.2020.1780251
Dries SS, et al. Evaluation of Oxidative Stress Biomarkers and Liver and Renal Functional Parameters in Patients During Treatment a Mental Health Unit to Treat Alcohol Dependence. Drug Chem Toxicol. 2020 Jun 22;1-7. PubMed PMID: 32567384.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of oxidative stress biomarkers and liver and renal functional parameters in patients during treatment a mental health unit to treat alcohol dependence. AU - Dries,Samuel Selbach, AU - Seibert,Bruna Scherer, AU - Bastiani,Marcos Frank, AU - Linden,Rafael, AU - Perassolo,Magda Susana, Y1 - 2020/06/22/ PY - 2020/6/23/entrez KW - Alcohol dependence KW - hepatic function KW - oxidative stress KW - renal function KW - treatment SP - 1 EP - 7 JF - Drug and chemical toxicology JO - Drug Chem Toxicol N2 - Alcohol dependence is one of the main reasons for inpatient admission to psychiatric hospitals. The abuse of this chemical substance can cause modifications in our organism and among them, variations in the oxidative stress parameters. Therefore, the aim of this study is to evaluate patients admitted to a psychiatric hospital unit to treat alcohol dependence, comparing oxidative stress, renal and hepatic function parameters from the moment of admission to those obtained at discharge. Hepatic function was verified through gamma-glutamyl-transferase (GGT), alkaline-phosphatase (ALP), aspartate-aminotransferase (AST) and alanine-aminotransferase (ALT) activity measurements. Urea and creatinine serum levels were measured for kidney function evaluation. Oxidative stress was evaluated by superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), ferric reducing antioxidant power (FRAP) and malondialdehyde (MDA). Medications used during hospital stay were record and their influence over the measured parameters analyzed. Twenty-eight patients (82% male, 44 ± 13 years old) were included in this study. A significant increase in BMI of patients after the period of hospitalization could be observed. There were reductions in creatinine, AST, ALT, GGT and ALP serum levels. SOD levels were lower at discharge, while GPx and FRAP presented higher levels. Chlorpromazine use showed influence over some hepatic function markers (ALT, GGT and ALP) and oxidative stress parameters (CAT and GPx); while carbamazepine use influenced GGT and FRAP. Patients on alcohol dependence treatment had significant improvements of renal and hepatic function parameters and higher GPx and FRAP values after the hospitalization period, which indicates reversion of alcohol effects over oxidative stress parameters. SN - 1525-6014 UR - https://www.unboundmedicine.com/medline/citation/32567384/Evaluation_of_oxidative_stress_biomarkers_and_liver_and_renal_functional_parameters_in_patients_during_treatment_a_mental_health_unit_to_treat_alcohol_dependence L2 - http://www.tandfonline.com/doi/full/10.1080/01480545.2020.1780251 DB - PRIME DP - Unbound Medicine ER -
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