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Evidence for transmission of COVID-19 prior to symptom onset.
Elife. 2020 06 22; 9E

Abstract

We collated contact tracing data from COVID-19 clusters in Singapore and Tianjin, China and estimated the extent of pre-symptomatic transmission by estimating incubation periods and serial intervals. The mean incubation periods accounting for intermediate cases were 4.91 days (95%CI 4.35, 5.69) and 7.54 (95%CI 6.76, 8.56) days for Singapore and Tianjin, respectively. The mean serial interval was 4.17 (95%CI 2.44, 5.89) and 4.31 (95%CI 2.91, 5.72) days (Singapore, Tianjin). The serial intervals are shorter than incubation periods, suggesting that pre-symptomatic transmission may occur in a large proportion of transmission events (0.4-0.5 in Singapore and 0.6-0.8 in Tianjin, in our analysis with intermediate cases, and more without intermediates). Given the evidence for pre-symptomatic transmission, it is vital that even individuals who appear healthy abide by public health measures to control COVID-19.

Authors+Show Affiliations

University of British Columbia, Vancouver, Canada.Simon Fraser University, Burnaby, Canada.University of British Columbia, Vancouver, Canada.Simon Fraser University, Burnaby, Canada.Simon Fraser University, Burnaby, Canada.University of British Columbia, Vancouver, Canada.National University of Singapore, Singapore, Singapore.Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands. Leiden University Medical Center, Leiden, Netherlands.Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands. Leiden University Medical Center, Leiden, Netherlands.Simon Fraser University, Burnaby, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32568070

Citation

Tindale, Lauren C., et al. "Evidence for Transmission of COVID-19 Prior to Symptom Onset." ELife, vol. 9, 2020.
Tindale LC, Stockdale JE, Coombe M, et al. Evidence for transmission of COVID-19 prior to symptom onset. Elife. 2020;9.
Tindale, L. C., Stockdale, J. E., Coombe, M., Garlock, E. S., Lau, W. Y. V., Saraswat, M., Zhang, L., Chen, D., Wallinga, J., & Colijn, C. (2020). Evidence for transmission of COVID-19 prior to symptom onset. ELife, 9. https://doi.org/10.7554/eLife.57149
Tindale LC, et al. Evidence for Transmission of COVID-19 Prior to Symptom Onset. Elife. 2020 06 22;9 PubMed PMID: 32568070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for transmission of COVID-19 prior to symptom onset. AU - Tindale,Lauren C, AU - Stockdale,Jessica E, AU - Coombe,Michelle, AU - Garlock,Emma S, AU - Lau,Wing Yin Venus, AU - Saraswat,Manu, AU - Zhang,Louxin, AU - Chen,Dongxuan, AU - Wallinga,Jacco, AU - Colijn,Caroline, Y1 - 2020/06/22/ PY - 2020/03/23/received PY - 2020/06/21/accepted PY - 2020/6/23/pubmed PY - 2020/8/6/medline PY - 2020/6/23/entrez KW - COVID19 KW - Sars-CoV-2 KW - coronavirus KW - epidemiology KW - global health KW - incubation KW - serial interval KW - transmission JF - eLife JO - Elife VL - 9 N2 - We collated contact tracing data from COVID-19 clusters in Singapore and Tianjin, China and estimated the extent of pre-symptomatic transmission by estimating incubation periods and serial intervals. The mean incubation periods accounting for intermediate cases were 4.91 days (95%CI 4.35, 5.69) and 7.54 (95%CI 6.76, 8.56) days for Singapore and Tianjin, respectively. The mean serial interval was 4.17 (95%CI 2.44, 5.89) and 4.31 (95%CI 2.91, 5.72) days (Singapore, Tianjin). The serial intervals are shorter than incubation periods, suggesting that pre-symptomatic transmission may occur in a large proportion of transmission events (0.4-0.5 in Singapore and 0.6-0.8 in Tianjin, in our analysis with intermediate cases, and more without intermediates). Given the evidence for pre-symptomatic transmission, it is vital that even individuals who appear healthy abide by public health measures to control COVID-19. SN - 2050-084X UR - https://www.unboundmedicine.com/medline/citation/32568070/Evidence_for_transmission_of_COVID_19_prior_to_symptom_onset_ L2 - https://doi.org/10.7554/eLife.57149 DB - PRIME DP - Unbound Medicine ER -