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Green fabrication of chitosan/tragacanth gum bionanocomposite films having TiO2@Ag hybrid for bioactivity and antibacterial applications.
Int J Biol Macromol. 2020 Nov 01; 162:512-522.IJ

Abstract

Common materials used in tissue engineering are not cost-effective and natural origin. Hence, we designed green, safe, and antibacterial bionanocomposite (bio-NC) films based on polysaccharides, chitosan (CS) and gum tragacanth (GT) for the bone tissue engineering. For this aim, different percentages of titanium dioxide nanoparticles (TiO2 NPs) and green silver (Ag)-doped TiO2 NPs (TiO2@Ag hybrid) were employed as nanofiller to improve the properties of the CS-GT film. Moreover, the physicochemical characteristics of the bio-NC films were examined with a field-emission scanning electron microscope (FE-SEM), Fourier transform infrared, X-ray diffraction, and transmission electron microscopy (TEM). The FE-SEM images showed a rough surface for the CS-GT/TiO2@Ag bio-NC films, and TEM images showed better dispersion of TiO2@Ag hybrid than TiO2 NPs into the CS-GT matrix. Also, these bio-NC films were considered for the bioactivity test and the results showed formation of hydroxyapatite on the surface of the prepared bio-NC films. Furthermore, addition of GT led to an increase in the bioactivity of the CS-GT blend. Finally, antibacterial behavior of the prepared bio-NC films was investigated against Escherichia coli and Staphylococcus aureus bacteria with/without ultraviolet irradiation and the results indicated better antibacterial performance for the CS-GT/TiO2@Ag bio-NC film (TiO2:Ag = 1:1) under both conditions.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Mallakpour S
Organic Polymer Chemistry Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Islamic Republic of Iran. Electronic address: mallak@iut.ac.ir.
Ramezanzade V
Organic Polymer Chemistry Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Islamic Republic of Iran.

MeSH

Anti-Bacterial AgentsChitosanEscherichia coliGreen Chemistry TechnologyNanocompositesSilverStaphylococcus aureusTitaniumTragacanth

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32569691

Citation

Mallakpour, Shadpour, and Vahid Ramezanzade. "Green Fabrication of Chitosan/tragacanth Gum Bionanocomposite Films Having TiO2@Ag Hybrid for Bioactivity and Antibacterial Applications." International Journal of Biological Macromolecules, vol. 162, 2020, pp. 512-522.
Mallakpour S, Ramezanzade V. Green fabrication of chitosan/tragacanth gum bionanocomposite films having TiO2@Ag hybrid for bioactivity and antibacterial applications. Int J Biol Macromol. 2020;162:512-522.
Mallakpour, S., & Ramezanzade, V. (2020). Green fabrication of chitosan/tragacanth gum bionanocomposite films having TiO2@Ag hybrid for bioactivity and antibacterial applications. International Journal of Biological Macromolecules, 162, 512-522. https://doi.org/10.1016/j.ijbiomac.2020.06.163
Mallakpour S, Ramezanzade V. Green Fabrication of Chitosan/tragacanth Gum Bionanocomposite Films Having TiO2@Ag Hybrid for Bioactivity and Antibacterial Applications. Int J Biol Macromol. 2020 Nov 1;162:512-522. PubMed PMID: 32569691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Green fabrication of chitosan/tragacanth gum bionanocomposite films having TiO2@Ag hybrid for bioactivity and antibacterial applications. AU - Mallakpour,Shadpour, AU - Ramezanzade,Vahid, Y1 - 2020/06/20/ PY - 2020/05/02/received PY - 2020/06/13/revised PY - 2020/06/17/accepted PY - 2020/6/23/pubmed PY - 2021/3/25/medline PY - 2020/6/23/entrez KW - Blending KW - Green Ag nanoparticles KW - Hydroxyapatite KW - Inhibition zone KW - Polysaccharide SP - 512 EP - 522 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 162 N2 - Common materials used in tissue engineering are not cost-effective and natural origin. Hence, we designed green, safe, and antibacterial bionanocomposite (bio-NC) films based on polysaccharides, chitosan (CS) and gum tragacanth (GT) for the bone tissue engineering. For this aim, different percentages of titanium dioxide nanoparticles (TiO2 NPs) and green silver (Ag)-doped TiO2 NPs (TiO2@Ag hybrid) were employed as nanofiller to improve the properties of the CS-GT film. Moreover, the physicochemical characteristics of the bio-NC films were examined with a field-emission scanning electron microscope (FE-SEM), Fourier transform infrared, X-ray diffraction, and transmission electron microscopy (TEM). The FE-SEM images showed a rough surface for the CS-GT/TiO2@Ag bio-NC films, and TEM images showed better dispersion of TiO2@Ag hybrid than TiO2 NPs into the CS-GT matrix. Also, these bio-NC films were considered for the bioactivity test and the results showed formation of hydroxyapatite on the surface of the prepared bio-NC films. Furthermore, addition of GT led to an increase in the bioactivity of the CS-GT blend. Finally, antibacterial behavior of the prepared bio-NC films was investigated against Escherichia coli and Staphylococcus aureus bacteria with/without ultraviolet irradiation and the results indicated better antibacterial performance for the CS-GT/TiO2@Ag bio-NC film (TiO2:Ag = 1:1) under both conditions. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/32569691/Green_fabrication_of_chitosan/tragacanth_gum_bionanocomposite_films_having_TiO2@Ag_hybrid_for_bioactivity_and_antibacterial_applications_ DB - PRIME DP - Unbound Medicine ER -