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Utility of salivary gland biopsy in diagnosing Sjogren's syndrome in a POTS patient population.
Auton Neurosci. 2020 09; 227:102694.AN

Abstract

PURPOSE

POTS patients undergo labial salivary gland biopsies (LSGB) for histologic confirmation of Sjogren's syndrome (SS). Predictive features of positive results are unknown.

METHODS

161 POTS patients underwent LSGB. Their charts were reviewed for antibody and diagnostic testing results.

RESULTS

Only 11% (17/161) of POTS patients were SS positive. There were more positive ANA antibodies in those with positive LSGB (65% v 28%, p = .0026). Positive skin nerve biopsy for small fiber neuropathy (SFN) was associated with positive LSGB (p = .046).

CONCLUSION

A positive ANA and skin biopsy for SFN are two helpful features in selecting POTS patients for LSGB.

Authors+Show Affiliations

Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, United States of America.Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, United States of America; Department of Dermatology, Cleveland Clinic, United States of America.Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, United States of America; Department of Neurology, Neuromuscular Center, Cleveland Clinic, United States of America. Electronic address: wilsonr3@ccf.org.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32570139

Citation

Pasadyn, Selena R., et al. "Utility of Salivary Gland Biopsy in Diagnosing Sjogren's Syndrome in a POTS Patient Population." Autonomic Neuroscience : Basic & Clinical, vol. 227, 2020, p. 102694.
Pasadyn SR, Warren CB, Wilson RG. Utility of salivary gland biopsy in diagnosing Sjogren's syndrome in a POTS patient population. Auton Neurosci. 2020;227:102694.
Pasadyn, S. R., Warren, C. B., & Wilson, R. G. (2020). Utility of salivary gland biopsy in diagnosing Sjogren's syndrome in a POTS patient population. Autonomic Neuroscience : Basic & Clinical, 227, 102694. https://doi.org/10.1016/j.autneu.2020.102694
Pasadyn SR, Warren CB, Wilson RG. Utility of Salivary Gland Biopsy in Diagnosing Sjogren's Syndrome in a POTS Patient Population. Auton Neurosci. 2020;227:102694. PubMed PMID: 32570139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Utility of salivary gland biopsy in diagnosing Sjogren's syndrome in a POTS patient population. AU - Pasadyn,Selena R, AU - Warren,Christine B, AU - Wilson,Robert G, Y1 - 2020/06/16/ PY - 2020/02/09/received PY - 2020/05/19/revised PY - 2020/06/08/accepted PY - 2020/6/23/pubmed PY - 2020/6/23/medline PY - 2020/6/23/entrez KW - Postural tachycardia syndrome KW - Sjogren's syndrome KW - Small fiber neuropathy SP - 102694 EP - 102694 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 227 N2 - PURPOSE: POTS patients undergo labial salivary gland biopsies (LSGB) for histologic confirmation of Sjogren's syndrome (SS). Predictive features of positive results are unknown. METHODS: 161 POTS patients underwent LSGB. Their charts were reviewed for antibody and diagnostic testing results. RESULTS: Only 11% (17/161) of POTS patients were SS positive. There were more positive ANA antibodies in those with positive LSGB (65% v 28%, p = .0026). Positive skin nerve biopsy for small fiber neuropathy (SFN) was associated with positive LSGB (p = .046). CONCLUSION: A positive ANA and skin biopsy for SFN are two helpful features in selecting POTS patients for LSGB. SN - 1872-7484 UR - https://www.unboundmedicine.com/medline/citation/32570139/Utility_of_salivary_gland_biopsy_in_diagnosing_Sjogren's_syndrome_in_a_POTS_patient_population L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(20)30128-4 DB - PRIME DP - Unbound Medicine ER -
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