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To study the changes in maternal hemodynamics with intravenous labetalol or nifedipine in acute severe hypertension.
Pregnancy Hypertens. 2020 Jul; 21:180-183.PH

Abstract

OBJECTIVE

To study the maternal hemodynamic changes in acute severe hypertension after treatment with intravenous labetalol or oral nifedipine using color doppler ultrasound.

STUDY DESIGN

We evaluated thirty pregnant women with gestational age between 28 and 40 weeks in acute severe hypertension (more than or equal to 160/105 mmHg) which were randomly allocated to receive either intravenous labetalol or oral nifedipine until blood pressure was lowered to less than or equal to 140/90 mmHg. Doppler vascular indices namely pulsatility index, resistance index, S/D ratio of bilateral uterine arteries and maternal renal artery were measured baseline at the time of acute severe hypertension and repeated after control of blood pressure, to assess the changes in maternal hemodynamics if any with labetalol or nifedipine.

RESULTS

When evaluating right uterine artery Doppler parameters, a trend to increase in PI and RI was observed in those who received labetalol and nifedipine however the difference was not statistically significant. Whereas, while evaluating left uterine artery indices a trend to decrease PI was seen in nifedipine group but the difference was not statistically significant. On intergroup comparison there was no any significant change in any of uterine artery as well as renal artery indices in either group.

CONCLUSION

The use of labetalol and nifedipine were not related to any significant changes in maternal Doppler, which is reassuring about the safety of these drugs when treating acute severe hypertension in pregnancy.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Thakur M
Department of Obstetrics & Gynaecology, YSPGMC, Nahan, India. Electronic address: thakurmonika126@gmail.com.
Gainder S
Department of Obstetrics & Gynaecology, PGIMER, Chandigarh, India.
Saha SC
Department of Obstetrics & Gynaecology, PGIMER, Chandigarh, India.
Prakash M
Department of Radiodiagnosis, PGIMER, Chandigarh, India.

MeSH

Administration, IntravenousAdministration, OralAdultAntihypertensive AgentsBlood PressureFemaleHumansHypertension, Pregnancy-InducedLabetalolNifedipinePlacentaPregnancyPulsatile FlowRenal ArteryUltrasonography, Doppler, ColorUterine Artery

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

32570152

Citation

Thakur, Monika, et al. "To Study the Changes in Maternal Hemodynamics With Intravenous Labetalol or Nifedipine in Acute Severe Hypertension." Pregnancy Hypertension, vol. 21, 2020, pp. 180-183.
Thakur M, Gainder S, Saha SC, et al. To study the changes in maternal hemodynamics with intravenous labetalol or nifedipine in acute severe hypertension. Pregnancy Hypertens. 2020;21:180-183.
Thakur, M., Gainder, S., Saha, S. C., & Prakash, M. (2020). To study the changes in maternal hemodynamics with intravenous labetalol or nifedipine in acute severe hypertension. Pregnancy Hypertension, 21, 180-183. https://doi.org/10.1016/j.preghy.2020.05.014
Thakur M, et al. To Study the Changes in Maternal Hemodynamics With Intravenous Labetalol or Nifedipine in Acute Severe Hypertension. Pregnancy Hypertens. 2020;21:180-183. PubMed PMID: 32570152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - To study the changes in maternal hemodynamics with intravenous labetalol or nifedipine in acute severe hypertension. AU - Thakur,Monika, AU - Gainder,Shalini, AU - Saha,S C, AU - Prakash,Mahesh, Y1 - 2020/05/29/ PY - 2019/09/01/received PY - 2020/05/19/revised PY - 2020/05/25/accepted PY - 2020/6/23/pubmed PY - 2021/5/28/medline PY - 2020/6/23/entrez KW - Acute severe hypertension KW - Doppler KW - Intravenous labetalol KW - Nifedipine KW - Pregnancy KW - Renal artery KW - Uterine artery SP - 180 EP - 183 JF - Pregnancy hypertension JO - Pregnancy Hypertens VL - 21 N2 - OBJECTIVE: To study the maternal hemodynamic changes in acute severe hypertension after treatment with intravenous labetalol or oral nifedipine using color doppler ultrasound. STUDY DESIGN: We evaluated thirty pregnant women with gestational age between 28 and 40 weeks in acute severe hypertension (more than or equal to 160/105 mmHg) which were randomly allocated to receive either intravenous labetalol or oral nifedipine until blood pressure was lowered to less than or equal to 140/90 mmHg. Doppler vascular indices namely pulsatility index, resistance index, S/D ratio of bilateral uterine arteries and maternal renal artery were measured baseline at the time of acute severe hypertension and repeated after control of blood pressure, to assess the changes in maternal hemodynamics if any with labetalol or nifedipine. RESULTS: When evaluating right uterine artery Doppler parameters, a trend to increase in PI and RI was observed in those who received labetalol and nifedipine however the difference was not statistically significant. Whereas, while evaluating left uterine artery indices a trend to decrease PI was seen in nifedipine group but the difference was not statistically significant. On intergroup comparison there was no any significant change in any of uterine artery as well as renal artery indices in either group. CONCLUSION: The use of labetalol and nifedipine were not related to any significant changes in maternal Doppler, which is reassuring about the safety of these drugs when treating acute severe hypertension in pregnancy. SN - 2210-7797 UR - https://www.unboundmedicine.com/medline/citation/32570152/To_study_the_changes_in_maternal_hemodynamics_with_intravenous_labetalol_or_nifedipine_in_acute_severe_hypertension_ DB - PRIME DP - Unbound Medicine ER -