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Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts.
Otolaryngol Head Neck Surg. 2020 Jun 23 [Online ahead of print]OH

Abstract

OBJECTIVE

To review the results of a series of patients with glottic insufficiency caused by scarred vocal folds who underwent injection laryngoplasty with centrifuged and emulsified autologous fat.

STUDY DESIGN

Prospective cohort.

SETTING

Single center, tertiary institution.

SUBJECTS AND METHODS

Examination of the medical records of 21 patients operated on through injection laryngoplasty with fat grafts for the treatment of dysphonia was performed. All patients were operated on between January of 2015 and September of 2019. The voice variables measured were the GRABS (Grade, Roughness, Breathiness, Asthenia, Strain) scale, the Voice Handicap Index-10 (VHI-10), maximum phonation time, jitter, shimmer, and harmonic/noise ratio before surgery and 8 months later.

RESULTS

Twenty-six injection laryngoplasties were performed in 21 patients during the reviewed period. Seventeen were men, and 4 were women. Mean age was 57.2 (range, 18-80) years. Mean (SD) follow-up time was 20.7 (9.3) months. Etiology of dysphonia was scarring after tumor resection in 17 patients and sulcus vocalis in 4. Five patients received an additional injection laryngoplasty. Statistically significant improvements were observed in all the parameters evaluated (P < .05).

CONCLUSIONS

Injection laryngoplasty with fat grafts processed through centrifugation and emulsification is an effective technique for the treatment of dysphonia caused by glottic insufficiency related to scarred vocal folds, with minimal complication rates.

Authors+Show Affiliations

University and Polytechnic Hospital La Fe, Valencia, Comunidad Valenciana, Spain.University and Polytechnic Hospital La Fe, Valencia, Comunidad Valenciana, Spain.University and Polytechnic Hospital La Fe, Valencia, Comunidad Valenciana, Spain.University and Polytechnic Hospital La Fe, Valencia, Comunidad Valenciana, Spain.University and Polytechnic Hospital La Fe, Valencia, Comunidad Valenciana, Spain.University and Polytechnic Hospital La Fe, Valencia, Comunidad Valenciana, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32571153

Citation

Salmerón-González, Enrique, et al. "Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 2020, p. 194599820932836.
Salmerón-González E, García-Vilariño E, Llópez-Carratalá I, et al. Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts. Otolaryngol Head Neck Surg. 2020.
Salmerón-González, E., García-Vilariño, E., Llópez-Carratalá, I., Collado-Martin, D., María Perolada-Valmaña, J., & Armengot-Carceller, M. (2020). Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 194599820932836. https://doi.org/10.1177/0194599820932836
Salmerón-González E, et al. Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts. Otolaryngol Head Neck Surg. 2020 Jun 23;194599820932836. PubMed PMID: 32571153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts. AU - Salmerón-González,Enrique, AU - García-Vilariño,Elena, AU - Llópez-Carratalá,Ignacio, AU - Collado-Martin,Diego, AU - María Perolada-Valmaña,José, AU - Armengot-Carceller,Miguel, Y1 - 2020/06/23/ PY - 2020/6/24/entrez KW - fat graft KW - injection laryngoplasty KW - vocal fold augmentation KW - voice SP - 194599820932836 EP - 194599820932836 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg N2 - OBJECTIVE: To review the results of a series of patients with glottic insufficiency caused by scarred vocal folds who underwent injection laryngoplasty with centrifuged and emulsified autologous fat. STUDY DESIGN: Prospective cohort. SETTING: Single center, tertiary institution. SUBJECTS AND METHODS: Examination of the medical records of 21 patients operated on through injection laryngoplasty with fat grafts for the treatment of dysphonia was performed. All patients were operated on between January of 2015 and September of 2019. The voice variables measured were the GRABS (Grade, Roughness, Breathiness, Asthenia, Strain) scale, the Voice Handicap Index-10 (VHI-10), maximum phonation time, jitter, shimmer, and harmonic/noise ratio before surgery and 8 months later. RESULTS: Twenty-six injection laryngoplasties were performed in 21 patients during the reviewed period. Seventeen were men, and 4 were women. Mean age was 57.2 (range, 18-80) years. Mean (SD) follow-up time was 20.7 (9.3) months. Etiology of dysphonia was scarring after tumor resection in 17 patients and sulcus vocalis in 4. Five patients received an additional injection laryngoplasty. Statistically significant improvements were observed in all the parameters evaluated (P < .05). CONCLUSIONS: Injection laryngoplasty with fat grafts processed through centrifugation and emulsification is an effective technique for the treatment of dysphonia caused by glottic insufficiency related to scarred vocal folds, with minimal complication rates. SN - 1097-6817 UR - https://www.unboundmedicine.com/medline/citation/32571153/Augmentation_of_Scarred_Vocal_Folds_With_Centrifuged_and_Emulsified_Autologous_Fat_Grafts L2 - https://journals.sagepub.com/doi/10.1177/0194599820932836?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -