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[Benefits and risks of ibuprofen in children with fever: Overview of the literature with a view to producing a written information tool for parents].
Therapie. 2020 May 16 [Online ahead of print]T

Abstract

Drug information, as it appears in package leaflet, lacks relevant encrypted data for the patient. The aim of our research was to propose a written model of drug information inspired from the concept of the "Drug Facts Box", about ibuprofen in children with fever. To this end, we carried out a systematic review of systematic literature reviews ("overview") to look for data on the benefits and risks of ibuprofen compared to placebo, paracetamol or a treatment alternating or combining paracetamol and ibuprofen in children with fever aged 0-18 years. 9 systematic reviews were included from the Pubmed/Medline, Embase and Cochrane databases. 1 clinical practice guideline and 2 documents published by the French Haute Autorité de santé (HAS) and the French Agence nationale de sécurité du médicament et des produits de santé (ANSM) were also included. Paracetamol and ibuprofen have a comparable efficacy and safety profile in children with fever. A low increased risk of adverse reactions to ibuprofen is to be feared in specifics clinical situations (chicken pox, pneumonia, angina). Treatments alternating or combining paracetamol and ibuprofen can further lower the temperature compared to paracetamol or ibuprofen alone, but there is no evidence of improved child comfort. The limited data available on the adverse effects of these treatment regimens suggests that they should not be routinely recommended. There is little evidence of the comfort of the febrile child even though it is the primary objective of antipyretic treatment.

Authors+Show Affiliations

Université Caen-Normandie, 14000 Caen, France.Université Caen-Normandie, 14000 Caen, France.Cabinet de médecine générale, 8, rue des Cerisiers, 14210 Evrecy, France. Electronic address: dr.benoit.soulie@orange.fr.

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

32571587

Citation

Faisantieu, Nicolas, et al. "[Benefits and Risks of Ibuprofen in Children With Fever: Overview of the Literature With a View to Producing a Written Information Tool for Parents]." Therapie, 2020.
Faisantieu N, Kowalski V, Soulié B. [Benefits and risks of ibuprofen in children with fever: Overview of the literature with a view to producing a written information tool for parents]. Therapie. 2020.
Faisantieu, N., Kowalski, V., & Soulié, B. (2020). [Benefits and risks of ibuprofen in children with fever: Overview of the literature with a view to producing a written information tool for parents]. Therapie. https://doi.org/10.1016/j.therap.2020.04.005
Faisantieu N, Kowalski V, Soulié B. [Benefits and Risks of Ibuprofen in Children With Fever: Overview of the Literature With a View to Producing a Written Information Tool for Parents]. Therapie. 2020 May 16; PubMed PMID: 32571587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Benefits and risks of ibuprofen in children with fever: Overview of the literature with a view to producing a written information tool for parents]. AU - Faisantieu,Nicolas, AU - Kowalski,Vincent, AU - Soulié,Benoît, Y1 - 2020/05/16/ PY - 2019/09/04/received PY - 2020/02/02/revised PY - 2020/04/29/accepted PY - 2020/6/24/entrez KW - Children KW - Communication en santé KW - Drug KW - Enfants KW - Fever KW - Fièvre KW - Health communication KW - Ibuprofen KW - Ibuprofène KW - Médicament JF - Therapie JO - Therapie N2 - Drug information, as it appears in package leaflet, lacks relevant encrypted data for the patient. The aim of our research was to propose a written model of drug information inspired from the concept of the "Drug Facts Box", about ibuprofen in children with fever. To this end, we carried out a systematic review of systematic literature reviews ("overview") to look for data on the benefits and risks of ibuprofen compared to placebo, paracetamol or a treatment alternating or combining paracetamol and ibuprofen in children with fever aged 0-18 years. 9 systematic reviews were included from the Pubmed/Medline, Embase and Cochrane databases. 1 clinical practice guideline and 2 documents published by the French Haute Autorité de santé (HAS) and the French Agence nationale de sécurité du médicament et des produits de santé (ANSM) were also included. Paracetamol and ibuprofen have a comparable efficacy and safety profile in children with fever. A low increased risk of adverse reactions to ibuprofen is to be feared in specifics clinical situations (chicken pox, pneumonia, angina). Treatments alternating or combining paracetamol and ibuprofen can further lower the temperature compared to paracetamol or ibuprofen alone, but there is no evidence of improved child comfort. The limited data available on the adverse effects of these treatment regimens suggests that they should not be routinely recommended. There is little evidence of the comfort of the febrile child even though it is the primary objective of antipyretic treatment. SN - 1958-5578 UR - https://www.unboundmedicine.com/medline/citation/32571587/[Benefits_and_risks_of_ibuprofen_in_children_with_fever:_Overview_of_the_literature_with_a_view_to_producing_a_written_information_tool_for_parents] L2 - https://linkinghub.elsevier.com/retrieve/pii/S0040-5957(20)30088-3 DB - PRIME DP - Unbound Medicine ER -
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