Citation
Fernández-Cruz, Ana, et al. "A Retrospective Controlled Cohort Study of the Impact of Glucocorticoid Treatment in SARS-CoV-2 Infection Mortality." Antimicrobial Agents and Chemotherapy, vol. 64, no. 9, 2020.
Fernández-Cruz A, Ruiz-Antorán B, Muñoz-Gómez A, et al. A Retrospective Controlled Cohort Study of the Impact of Glucocorticoid Treatment in SARS-CoV-2 Infection Mortality. Antimicrob Agents Chemother. 2020;64(9).
Fernández-Cruz, A., Ruiz-Antorán, B., Muñoz-Gómez, A., Sancho-López, A., Mills-Sánchez, P., Centeno-Soto, G. A., Blanco-Alonso, S., Javaloyes-Garachana, L., Galán-Gómez, A., Valencia-Alijo, Á., Gómez-Irusta, J., Payares-Herrera, C., Morrás-Torre, I., Sánchez-Chica, E., Delgado-Téllez-de-Cepeda, L., Callejas-Díaz, A., Ramos-Martínez, A., Múñez-Rubio, E., & Avendaño-Solá, C. (2020). A Retrospective Controlled Cohort Study of the Impact of Glucocorticoid Treatment in SARS-CoV-2 Infection Mortality. Antimicrobial Agents and Chemotherapy, 64(9). https://doi.org/10.1128/AAC.01168-20
Fernández-Cruz A, et al. A Retrospective Controlled Cohort Study of the Impact of Glucocorticoid Treatment in SARS-CoV-2 Infection Mortality. Antimicrob Agents Chemother. 2020 08 20;64(9) PubMed PMID: 32571831.
TY - JOUR
T1 - A Retrospective Controlled Cohort Study of the Impact of Glucocorticoid Treatment in SARS-CoV-2 Infection Mortality.
AU - Fernández-Cruz,Ana,
AU - Ruiz-Antorán,Belén,
AU - Muñoz-Gómez,Ana,
AU - Sancho-López,Aránzazu,
AU - Mills-Sánchez,Patricia,
AU - Centeno-Soto,Gustavo Adolfo,
AU - Blanco-Alonso,Silvia,
AU - Javaloyes-Garachana,Laura,
AU - Galán-Gómez,Amy,
AU - Valencia-Alijo,Ángela,
AU - Gómez-Irusta,Javier,
AU - Payares-Herrera,Concepción,
AU - Morrás-Torre,Ignacio,
AU - Sánchez-Chica,Enrique,
AU - Delgado-Téllez-de-Cepeda,Laura,
AU - Callejas-Díaz,Alejandro,
AU - Ramos-Martínez,Antonio,
AU - Múñez-Rubio,Elena,
AU - Avendaño-Solá,Cristina,
Y1 - 2020/08/20/
PY - 2020/06/08/received
PY - 2020/06/19/accepted
PY - 2020/6/24/pubmed
PY - 2020/9/4/medline
PY - 2020/6/24/entrez
KW - COVID-19
KW - mortality
KW - steroids
JF - Antimicrobial agents and chemotherapy
JO - Antimicrob Agents Chemother
VL - 64
IS - 9
N2 - Evidence to support the use of steroids in coronavirus disease 2019 (COVID-19) pneumonia is lacking. We aim to determine the impact of steroid use for COVID-19 pneumonia on hospital mortality. We performed a single-center retrospective cohort study in a university hospital in Madrid, Spain, during March of 2020. To determine the role of steroids in in-hospital mortality, patients admitted with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia and treated with steroids were compared to patients not treated with steroids, and we adjusted with a propensity score for patients on steroid treatment. Survival times were compared using the log rank test. Different steroid regimens were compared and adjusted with a second propensity score. During the study period, 463 out of 848 hospitalized patients with COVID-19 pneumonia fulfilled inclusion criteria. Among them, 396 (46.7%) patients were treated with steroids and 67 patients were not. Global mortality was 15.1%. The median time to steroid treatment from symptom onset was 10 days (interquartile range [IQR], 8 to 13 days). In-hospital mortality was lower in patients treated with steroids than in controls (13.9% [55/396] versus 23.9% [16/67]; hazard ratio [HR], 0.51 [95% confidence interval, 0.27 to 0.96]; P = 0.044). Steroid treatment reduced mortality by 41.8% relative to the mortality with no steroid treatment (relative risk reduction, 0.42 [95% confidence interval, 0.048 to 0.65]). Initial treatment with 1 mg/kg of body weight/day of methylprednisolone versus steroid pulses was not associated with in-hospital mortality (13.5% [42/310] versus 15.1% [13/86]; odds ratio [OR], 0.880 [95% confidence interval, 0.449 to 1.726]; P = 0.710). Our results show that the survival of patients with SARS-CoV-2 pneumonia is higher in patients treated with glucocorticoids than in those not treated. Rates of in-hospital mortality were not different between initial regimens of 1 mg/kg/day of methylprednisolone and glucocorticoid pulses.
SN - 1098-6596
UR - https://www.unboundmedicine.com/medline/citation/32571831/A_Retrospective_Controlled_Cohort_Study_of_the_Impact_of_Glucocorticoid_Treatment_in_SARS_CoV_2_Infection_Mortality_
L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=32571831
DB - PRIME
DP - Unbound Medicine
ER -