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Acoustic trapping of microbubbles in complex environments and controlled payload release.
Proc Natl Acad Sci U S A. 2020 Jul 07; 117(27):15490-15496.PN

Abstract

Contactless manipulation of microparticles using acoustic waves holds promise for applications ranging from cell sorting to three-dimensional (3D) printing and tissue engineering. However, the unique potential of acoustic trapping to be applied in biomedical settings remains largely untapped. In particular, the main advantage of acoustic trapping over optical trapping, namely the ability of sound to propagate through thick and opaque media, has not yet been exploited in full. Here we demonstrate experimentally the use of the recently developed technique of single-beam acoustical tweezers to trap microbubbles, an important class of biomedically relevant microparticles. We show that the region of vanishing pressure of a propagating vortex beam can confine a microbubble by forcing low-amplitude, nonspherical, shape oscillations, enabling its full 3D positioning. Our interpretation is validated by the absolute calibration of the acoustic trapping force and the direct spatial mapping of isolated bubble echos, for which both find excellent agreement with our theoretical model. Furthermore, we prove the stability of the trap through centimeter-thick layers of bio-mimicking, elastic materials. Finally, we demonstrate the simultaneous trapping of nanoparticle-loaded microbubbles and activation with an independent acoustic field to trigger the release of the nanoparticles. Overall, using exclusively acoustic powering to position and actuate microbubbles paves the way toward controlled delivery of drug payloads in confined, hard-to-reach locations, with potential in vivo applications.

Authors+Show Affiliations

Department of Chemical Engineering, Imperial College London, London SW7 2AZ, United Kingdom; diego.baresch@u-bordeaux.fr. University of Bordeaux, CNRS, Institut de Mécanique et d'Ingénierie (I2M), UMR 5295, F-33405 Talence, France.Department of Chemical Engineering, Imperial College London, London SW7 2AZ, United Kingdom. Department of Chemical Engineering, Delft University of Technology, 2629 HZ Delft, The Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32571936

Citation

Baresch, Diego, and Valeria Garbin. "Acoustic Trapping of Microbubbles in Complex Environments and Controlled Payload Release." Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, 2020, pp. 15490-15496.
Baresch D, Garbin V. Acoustic trapping of microbubbles in complex environments and controlled payload release. Proc Natl Acad Sci USA. 2020;117(27):15490-15496.
Baresch, D., & Garbin, V. (2020). Acoustic trapping of microbubbles in complex environments and controlled payload release. Proceedings of the National Academy of Sciences of the United States of America, 117(27), 15490-15496. https://doi.org/10.1073/pnas.2003569117
Baresch D, Garbin V. Acoustic Trapping of Microbubbles in Complex Environments and Controlled Payload Release. Proc Natl Acad Sci USA. 2020 Jul 7;117(27):15490-15496. PubMed PMID: 32571936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acoustic trapping of microbubbles in complex environments and controlled payload release. AU - Baresch,Diego, AU - Garbin,Valeria, Y1 - 2020/06/22/ PY - 2020/6/24/pubmed PY - 2020/6/24/medline PY - 2020/6/24/entrez KW - acoustic force KW - acoustical tweezers KW - microbubbles KW - micromanipulation SP - 15490 EP - 15496 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc. Natl. Acad. Sci. U.S.A. VL - 117 IS - 27 N2 - Contactless manipulation of microparticles using acoustic waves holds promise for applications ranging from cell sorting to three-dimensional (3D) printing and tissue engineering. However, the unique potential of acoustic trapping to be applied in biomedical settings remains largely untapped. In particular, the main advantage of acoustic trapping over optical trapping, namely the ability of sound to propagate through thick and opaque media, has not yet been exploited in full. Here we demonstrate experimentally the use of the recently developed technique of single-beam acoustical tweezers to trap microbubbles, an important class of biomedically relevant microparticles. We show that the region of vanishing pressure of a propagating vortex beam can confine a microbubble by forcing low-amplitude, nonspherical, shape oscillations, enabling its full 3D positioning. Our interpretation is validated by the absolute calibration of the acoustic trapping force and the direct spatial mapping of isolated bubble echos, for which both find excellent agreement with our theoretical model. Furthermore, we prove the stability of the trap through centimeter-thick layers of bio-mimicking, elastic materials. Finally, we demonstrate the simultaneous trapping of nanoparticle-loaded microbubbles and activation with an independent acoustic field to trigger the release of the nanoparticles. Overall, using exclusively acoustic powering to position and actuate microbubbles paves the way toward controlled delivery of drug payloads in confined, hard-to-reach locations, with potential in vivo applications. SN - 1091-6490 UR - https://www.unboundmedicine.com/medline/citation/32571936/Acoustic_trapping_of_microbubbles_in_complex_environments_and_controlled_payload_release L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=32571936 DB - PRIME DP - Unbound Medicine ER -
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