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Literature-based review of the drugs used for the treatment of COVID-19.
Curr Med Res Pract. 2020 May-Jun; 10(3):100-109.CM

Abstract

COVID-19 is primarily a respiratory disease caused by a newly discovered SARS-CoV-2 virus and identified in the city of Wuhan, China in December 2019. WHO has declared this disease as a pandemic, and warned other countries. Presently this has affected 216 countries, areas or territories worldwide, spreading of this disease is very fast in USA, Brazil, and Russia than in the country of its origin, China. Like other coronaviruses, this may develop respiratory tract infections in the patients range from mild to fatal illness like pneumonia and acute respiratory distress syndrome (ARDS). As of now, no effective drug, vaccine, or any procedure is available and experiments are underway. However, empirical therapy is being followed to manage and save the lives of the patients. There is a need for pharmacological alternatives to combat this deadly virus and its complications. Based on the previous experiences with similar coronavirus management and present preliminary data from uncontrolled studies, drugs like chloroquine, hydroxychloroquine, remdesivir, lopinavir/ritonavir, and favipiravir have been recommended by the researchers to manage COVID-19. This review had assessed the potential mechanisms, safety profile, availability and cost of these drugs. This review concludes that the drugs mentioned above are having different properties and act differently in combating the COVID-19 viruses. Instead of single drug, combination of antivirals with different mechanism of action may be more effective and at the same time their adverse events should not be underestimated.

Authors+Show Affiliations

Jawaharlal Nehru Technological University Anantapur (JNTUA), Ananthapuramu, Andhra Pradesh, India.Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India.Department of Chemical Engineering, JNTUA College of Engineering, Ananthapuramu, Andhra Pradesh, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32572376

Citation

Venkatasubbaiah, Meda, et al. "Literature-based Review of the Drugs Used for the Treatment of COVID-19." Current Medicine Research and Practice, vol. 10, no. 3, 2020, pp. 100-109.
Venkatasubbaiah M, Dwarakanadha Reddy P, Satyanarayana SV. Literature-based review of the drugs used for the treatment of COVID-19. Curr Med Res Pract. 2020;10(3):100-109.
Venkatasubbaiah, M., Dwarakanadha Reddy, P., & Satyanarayana, S. V. (2020). Literature-based review of the drugs used for the treatment of COVID-19. Current Medicine Research and Practice, 10(3), 100-109. https://doi.org/10.1016/j.cmrp.2020.05.013
Venkatasubbaiah M, Dwarakanadha Reddy P, Satyanarayana SV. Literature-based Review of the Drugs Used for the Treatment of COVID-19. Curr Med Res Pract. 2020 May-Jun;10(3):100-109. PubMed PMID: 32572376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Literature-based review of the drugs used for the treatment of COVID-19. AU - Venkatasubbaiah,Meda, AU - Dwarakanadha Reddy,P, AU - Satyanarayana,Suggala V, Y1 - 2020/06/18/ PY - 2020/04/11/received PY - 2020/05/26/revised PY - 2020/05/29/accepted PY - 2020/6/24/entrez PY - 2020/6/24/pubmed PY - 2020/6/24/medline KW - COVID-19 KW - Coronavirus KW - Hydroxychloroquine KW - Remdesivir KW - Treatment SP - 100 EP - 109 JF - Current medicine research and practice JO - Curr Med Res Pract VL - 10 IS - 3 N2 - COVID-19 is primarily a respiratory disease caused by a newly discovered SARS-CoV-2 virus and identified in the city of Wuhan, China in December 2019. WHO has declared this disease as a pandemic, and warned other countries. Presently this has affected 216 countries, areas or territories worldwide, spreading of this disease is very fast in USA, Brazil, and Russia than in the country of its origin, China. Like other coronaviruses, this may develop respiratory tract infections in the patients range from mild to fatal illness like pneumonia and acute respiratory distress syndrome (ARDS). As of now, no effective drug, vaccine, or any procedure is available and experiments are underway. However, empirical therapy is being followed to manage and save the lives of the patients. There is a need for pharmacological alternatives to combat this deadly virus and its complications. Based on the previous experiences with similar coronavirus management and present preliminary data from uncontrolled studies, drugs like chloroquine, hydroxychloroquine, remdesivir, lopinavir/ritonavir, and favipiravir have been recommended by the researchers to manage COVID-19. This review had assessed the potential mechanisms, safety profile, availability and cost of these drugs. This review concludes that the drugs mentioned above are having different properties and act differently in combating the COVID-19 viruses. Instead of single drug, combination of antivirals with different mechanism of action may be more effective and at the same time their adverse events should not be underestimated. SN - 2352-0825 UR - https://www.unboundmedicine.com/medline/citation/32572376/Literature_based_review_of_the_drugs_used_for_the_treatment_of_COVID_19_ DB - PRIME DP - Unbound Medicine ER -
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