Tags

Type your tag names separated by a space and hit enter

Balanophora polyandra Griff. prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome.
Food Funct. 2020 Jul 22; 11(7):6104-6114.FF

Abstract

Balanophora polyandra Griff. (B. polyandra) is a folk medicine used as an antipyretic, antidote, haemostatic, dressing and haematic tonic, for the treatment of gonorrhea, syphilis, wounds, and the bleeding of the alimentary tract by the local people in China. This study was designed to investigate the effects of B. polyandra on dextran sulfate sodium (DSS)-treated colitis mice in vivo and lipopolysaccharide (LPS)-induced RAW 264.7 macrophages in vitro. Mice were induced with B. polyandra total extract (BPE, 250 and 1000 mg kg-1) and B. polyandra polysaccharides (BPP, 100 and 400 mg kg-1) for 22 days and treated with 3.5% DSS in their drinking water for the last 7 days and the LPS-induced RAW264.7 macrophages were treated with BPE (100 μg ml-1) and BPP (100 μg ml-1). Mice treated with DSS developed severe mucosal colitis, with a marked distortion and crypt loss of colonic surface epithelium and a colonic shortening. B. polyandra significantly inhibited colonic shortening and reduced the severity of colitis in the colon and lowered the colonic inflammation score (p < 0.05) and decreased the expression of interleukin (IL)-1β, tumor necrosis factor (TNF-α), inducible nitric oxide synthase (iNOS), and anti-serum amyloid A3 (SAA3) as well as the pro-inflammatory chemokine C-X-C motif chemokine 10 (CXCL10). B. polyandra also significantly suppressed the activation of nucleotide-binding domain like receptor protein 3 (NLRP3) inflammasome and the nuclear factor kB (NF-κB). These results suggest that dietary intake of B. polyandra ameliorates colitis. Such activities of B. polyandra in humans remain to be investigated.

Authors+Show Affiliations

College of Medical Science, China Three Gorges University, Yichang, 443002, China. yuancf46@ctgu.edu.cn.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32572399

Citation

Guo, Chong, et al. "Balanophora Polyandra Griff. Prevents Dextran Sulfate Sodium-induced Murine Experimental Colitis Via the Regulation of NF-κB and NLRP3 Inflammasome." Food & Function, vol. 11, no. 7, 2020, pp. 6104-6114.
Guo C, He Y, Gai L, et al. Balanophora polyandra Griff. prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome. Food Funct. 2020;11(7):6104-6114.
Guo, C., He, Y., Gai, L., Qu, J., Shi, Y., Xu, W., Cai, Y., Wang, B., Zhang, J., Zhao, Z., & Yuan, C. (2020). Balanophora polyandra Griff. prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome. Food & Function, 11(7), 6104-6114. https://doi.org/10.1039/c9fo02494h
Guo C, et al. Balanophora Polyandra Griff. Prevents Dextran Sulfate Sodium-induced Murine Experimental Colitis Via the Regulation of NF-κB and NLRP3 Inflammasome. Food Funct. 2020 Jul 22;11(7):6104-6114. PubMed PMID: 32572399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Balanophora polyandra Griff. prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome. AU - Guo,Chong, AU - He,Yumin, AU - Gai,Liyue, AU - Qu,Jiayuan, AU - Shi,Yue, AU - Xu,Wen, AU - Cai,Yuxuan, AU - Wang,Bei, AU - Zhang,Jiali, AU - Zhao,Zongyao, AU - Yuan,Chengfu, PY - 2020/6/24/pubmed PY - 2020/6/24/medline PY - 2020/6/24/entrez SP - 6104 EP - 6114 JF - Food & function JO - Food Funct VL - 11 IS - 7 N2 - Balanophora polyandra Griff. (B. polyandra) is a folk medicine used as an antipyretic, antidote, haemostatic, dressing and haematic tonic, for the treatment of gonorrhea, syphilis, wounds, and the bleeding of the alimentary tract by the local people in China. This study was designed to investigate the effects of B. polyandra on dextran sulfate sodium (DSS)-treated colitis mice in vivo and lipopolysaccharide (LPS)-induced RAW 264.7 macrophages in vitro. Mice were induced with B. polyandra total extract (BPE, 250 and 1000 mg kg-1) and B. polyandra polysaccharides (BPP, 100 and 400 mg kg-1) for 22 days and treated with 3.5% DSS in their drinking water for the last 7 days and the LPS-induced RAW264.7 macrophages were treated with BPE (100 μg ml-1) and BPP (100 μg ml-1). Mice treated with DSS developed severe mucosal colitis, with a marked distortion and crypt loss of colonic surface epithelium and a colonic shortening. B. polyandra significantly inhibited colonic shortening and reduced the severity of colitis in the colon and lowered the colonic inflammation score (p < 0.05) and decreased the expression of interleukin (IL)-1β, tumor necrosis factor (TNF-α), inducible nitric oxide synthase (iNOS), and anti-serum amyloid A3 (SAA3) as well as the pro-inflammatory chemokine C-X-C motif chemokine 10 (CXCL10). B. polyandra also significantly suppressed the activation of nucleotide-binding domain like receptor protein 3 (NLRP3) inflammasome and the nuclear factor kB (NF-κB). These results suggest that dietary intake of B. polyandra ameliorates colitis. Such activities of B. polyandra in humans remain to be investigated. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/32572399/Balanophora_polyandra_Griff._prevents_dextran_sulfate_sodium-induced_murine_experimental_colitis_via_the_regulation_of_NF-κB_and_NLRP3_inflammasome L2 - https://doi.org/10.1039/c9fo02494h DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.