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Impact of intramural non-cavity-distorting leiomyoma on placental histopathology and perinatal outcome in singleton live births resulting from in vitro fertilization treatment.
J Assist Reprod Genet. 2020 Jun 23 [Online ahead of print]JA

Abstract

PURPOSE

To evaluate the effect of non-cavity-distorting intramural leiomyomas on the placental histopathology pattern and perinatal outcome in singleton live births resulting from in vitro fertilization treatment.

METHODS

The study population included all singleton live births following in vitro fertilization treatment with autologous oocytes during the period from 2009 to 2017. Primary outcomes included anatomical, inflammation, vascular malperfusion, and villous maturation placental features. Secondary outcomes included fetal, maternal, delivery, and perinatal complications.

RESULTS

A total of 1119 live births were included in the final analysis and were allocated to the group of pregnancies with non-cavity-distorting intramural myomas (n = 101) and without myomas (n = 1018). After the adjustment for confounding factors, the non-cavity-distorting intramural myomas were found to be significantly associated with assisted placental delivery (OR 2.4; 95% CI 1.5-3.9), furcate cord insertion (OR 3.6; 95% CI 1.4-9.3), circumvallate membranes insertion (OR 5.2; 95% CI 1.4-19.3), chronic deciduitis (OR 8.2; 95% CI 1.6-42.2), focal intramural fibrin deposition (OR 25.1; 95% CI 2.1-306.2), subchorionic thrombi (OR 3.6; 95% CI 1.7-7.6), maternal vasculopathy (OR 2.5; 95% CI 1.2-5.5), and chorangioma (OR 5.9; 95% CI 1.4-25.2) as well as with the failure of labor progress (OR 2.4; 95% CI 1.3-4.4) and induction (OR 3.2; 95% CI 1.2-9.0).

CONCLUSION

Intramural non-cavity-distorting myomas have a significant impact on the placental histopathology with a higher incidence of dysfunctional labor.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, 1001 Decarie Blvd., Montreal, H4A 3J1, Canada. alexander.volodarsky-perel@mail.mcgill.ca. Lady Davis Research Institute, Jewish General Hospital, McGill University, 3755 Chemin de la Côte-Sainte-Catherine, Montreal, H3T 1E2, Canada. alexander.volodarsky-perel@mail.mcgill.ca.Department of Pathology, Royal Victoria Hospital, McGill University, 1001 Decarie Blvd., Montreal, H4A 3J1, Canada.Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, 1001 Decarie Blvd., Montreal, H4A 3J1, Canada.Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, 1001 Decarie Blvd., Montreal, H4A 3J1, Canada.Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, 1001 Decarie Blvd., Montreal, H4A 3J1, Canada.Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, 1001 Decarie Blvd., Montreal, H4A 3J1, Canada.Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, 1001 Decarie Blvd., Montreal, H4A 3J1, Canada.Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, 1001 Decarie Blvd., Montreal, H4A 3J1, Canada.Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, 1001 Decarie Blvd., Montreal, H4A 3J1, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32572673

Citation

Volodarsky-Perel, Alexander, et al. "Impact of Intramural Non-cavity-distorting Leiomyoma On Placental Histopathology and Perinatal Outcome in Singleton Live Births Resulting From in Vitro Fertilization Treatment." Journal of Assisted Reproduction and Genetics, 2020.
Volodarsky-Perel A, Nu TNT, Tulandi T, et al. Impact of intramural non-cavity-distorting leiomyoma on placental histopathology and perinatal outcome in singleton live births resulting from in vitro fertilization treatment. J Assist Reprod Genet. 2020.
Volodarsky-Perel, A., Nu, T. N. T., Tulandi, T., Buckett, W., Gil, Y., Machado-Gedeon, A., Cui, Y., Shaul, J., & Dahan, M. H. (2020). Impact of intramural non-cavity-distorting leiomyoma on placental histopathology and perinatal outcome in singleton live births resulting from in vitro fertilization treatment. Journal of Assisted Reproduction and Genetics. https://doi.org/10.1007/s10815-020-01867-7
Volodarsky-Perel A, et al. Impact of Intramural Non-cavity-distorting Leiomyoma On Placental Histopathology and Perinatal Outcome in Singleton Live Births Resulting From in Vitro Fertilization Treatment. J Assist Reprod Genet. 2020 Jun 23; PubMed PMID: 32572673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of intramural non-cavity-distorting leiomyoma on placental histopathology and perinatal outcome in singleton live births resulting from in vitro fertilization treatment. AU - Volodarsky-Perel,Alexander, AU - Nu,Tuyet Nhung Ton, AU - Tulandi,Togas, AU - Buckett,William, AU - Gil,Yaron, AU - Machado-Gedeon,Alexandre, AU - Cui,Yiming, AU - Shaul,Jonathan, AU - Dahan,Michael H, Y1 - 2020/06/23/ PY - 2020/03/26/received PY - 2020/06/17/accepted PY - 2020/6/24/entrez KW - Dysfunctional labor KW - Histopathology KW - Intramural myoma KW - Placenta KW - Uterine cavity JF - Journal of assisted reproduction and genetics JO - J. Assist. Reprod. Genet. N2 - PURPOSE: To evaluate the effect of non-cavity-distorting intramural leiomyomas on the placental histopathology pattern and perinatal outcome in singleton live births resulting from in vitro fertilization treatment. METHODS: The study population included all singleton live births following in vitro fertilization treatment with autologous oocytes during the period from 2009 to 2017. Primary outcomes included anatomical, inflammation, vascular malperfusion, and villous maturation placental features. Secondary outcomes included fetal, maternal, delivery, and perinatal complications. RESULTS: A total of 1119 live births were included in the final analysis and were allocated to the group of pregnancies with non-cavity-distorting intramural myomas (n = 101) and without myomas (n = 1018). After the adjustment for confounding factors, the non-cavity-distorting intramural myomas were found to be significantly associated with assisted placental delivery (OR 2.4; 95% CI 1.5-3.9), furcate cord insertion (OR 3.6; 95% CI 1.4-9.3), circumvallate membranes insertion (OR 5.2; 95% CI 1.4-19.3), chronic deciduitis (OR 8.2; 95% CI 1.6-42.2), focal intramural fibrin deposition (OR 25.1; 95% CI 2.1-306.2), subchorionic thrombi (OR 3.6; 95% CI 1.7-7.6), maternal vasculopathy (OR 2.5; 95% CI 1.2-5.5), and chorangioma (OR 5.9; 95% CI 1.4-25.2) as well as with the failure of labor progress (OR 2.4; 95% CI 1.3-4.4) and induction (OR 3.2; 95% CI 1.2-9.0). CONCLUSION: Intramural non-cavity-distorting myomas have a significant impact on the placental histopathology with a higher incidence of dysfunctional labor. SN - 1573-7330 UR - https://www.unboundmedicine.com/medline/citation/32572673/Impact_of_intramural_non-cavity-distorting_leiomyoma_on_placental_histopathology_and_perinatal_outcome_in_singleton_live_births_resulting_from_in_vitro_fertilization_treatment L2 - https://doi.org/10.1007/s10815-020-01867-7 DB - PRIME DP - Unbound Medicine ER -
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