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The effect of pneumococcal conjugate vaccines on otitis media from 2005 to 2013 in children aged ≤5 years: a retrospective cohort study in two Swedish regions.
Hum Vaccin Immunother. 2021 02 01; 17(2):517-526.HV

Abstract

Seven-valent pneumococcal conjugate vaccine (PCV7) was introduced to Sweden in 2009 and replaced by pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) or 13-valent PCV (PCV13) from late 2009. A retrospective cohort study assessed the impact of PCVs on otitis media/acute otitis media (OM) in children aged ≤5 years (NCT02742753) living in Skåne (PCV7 then PHiD-CV) or Västra Götalandsregionen (PCV7 then PCV13) between 2005 and 2013 using linked regional and national databases. Time-series analyses described differences between pre-PCV and post-PCV eras. Adjusted age-period-cohort (APC) predictive models estimated vaccine effectiveness and OM incidence ratios between PCV cohorts. Time-to-first OM diagnosis was estimated in ≤2 year-olds by survival analysis using a Cox proportional hazards model. Descriptive interrupted time-series analyses showed OM incidence in ≤2 year-olds declined by 42% (Skåne) and 25% (Västra Götalandsregionen) after PHiD-CV/PCV13, respectively, versus pre-PCV, but baseline OM incidence and duration of PCV7 use differed between regions. In adjusted APC models, OM incidence decreased after PHiD-CV by 9.9% (95% confidence interval [CI]: 4.4; 15.1, p < .001) and PCV13 by 2.3% (95%CI: -3.2; 7.6, p = .401) compared with pre-PCV. Both PHiD-CV and PCV13 decreased the risk of first OM diagnosis: hazard ratio (95%CI) for PHiD-CV relative to pre-PCV 0.67 (0.65; 0.69); 0.87 (0.85; 0.89) for PCV13 relative to pre-PCV; p < .001 for both comparisons. Within the limitations of this study conducted in two large Swedish regions, descriptive time-series analyses showed that OM incidence rates declined following the introduction of PHiD-CV and PCV13; however, this reduction only reached statistical significance for PHiD-CV in the adjusted APC models.

Authors+Show Affiliations

Parexel International , Stockholm, Sweden.Parexel International , Stockholm, Sweden.Parexel International , Stockholm, Sweden.Parexel International , Stockholm, Sweden.Parexel International , Stockholm, Sweden.GSK , Wavre, Belgium.GSK , Rockville, MD, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32574101

Citation

Edmondson-Jones, Mark, et al. "The Effect of Pneumococcal Conjugate Vaccines On Otitis Media From 2005 to 2013 in Children Aged ≤5 Years: a Retrospective Cohort Study in Two Swedish Regions." Human Vaccines & Immunotherapeutics, vol. 17, no. 2, 2021, pp. 517-526.
Edmondson-Jones M, Dibbern T, Hultberg M, et al. The effect of pneumococcal conjugate vaccines on otitis media from 2005 to 2013 in children aged ≤5 years: a retrospective cohort study in two Swedish regions. Hum Vaccin Immunother. 2021;17(2):517-526.
Edmondson-Jones, M., Dibbern, T., Hultberg, M., Anell, B., Medin, E., Feng, Y., & Talarico, C. (2021). The effect of pneumococcal conjugate vaccines on otitis media from 2005 to 2013 in children aged ≤5 years: a retrospective cohort study in two Swedish regions. Human Vaccines & Immunotherapeutics, 17(2), 517-526. https://doi.org/10.1080/21645515.2020.1775455
Edmondson-Jones M, et al. The Effect of Pneumococcal Conjugate Vaccines On Otitis Media From 2005 to 2013 in Children Aged ≤5 Years: a Retrospective Cohort Study in Two Swedish Regions. Hum Vaccin Immunother. 2021 02 1;17(2):517-526. PubMed PMID: 32574101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of pneumococcal conjugate vaccines on otitis media from 2005 to 2013 in children aged ≤5 years: a retrospective cohort study in two Swedish regions. AU - Edmondson-Jones,Mark, AU - Dibbern,Therese, AU - Hultberg,Marcus, AU - Anell,Bengt, AU - Medin,Emma, AU - Feng,Yang, AU - Talarico,Carla, Y1 - 2020/06/23/ PY - 2020/6/24/pubmed PY - 2021/6/23/medline PY - 2020/6/24/entrez KW - Otitis media KW - Sweden KW - age-period-cohort KW - incidence KW - pneumococcal conjugate vaccine KW - time-series SP - 517 EP - 526 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 17 IS - 2 N2 - Seven-valent pneumococcal conjugate vaccine (PCV7) was introduced to Sweden in 2009 and replaced by pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) or 13-valent PCV (PCV13) from late 2009. A retrospective cohort study assessed the impact of PCVs on otitis media/acute otitis media (OM) in children aged ≤5 years (NCT02742753) living in Skåne (PCV7 then PHiD-CV) or Västra Götalandsregionen (PCV7 then PCV13) between 2005 and 2013 using linked regional and national databases. Time-series analyses described differences between pre-PCV and post-PCV eras. Adjusted age-period-cohort (APC) predictive models estimated vaccine effectiveness and OM incidence ratios between PCV cohorts. Time-to-first OM diagnosis was estimated in ≤2 year-olds by survival analysis using a Cox proportional hazards model. Descriptive interrupted time-series analyses showed OM incidence in ≤2 year-olds declined by 42% (Skåne) and 25% (Västra Götalandsregionen) after PHiD-CV/PCV13, respectively, versus pre-PCV, but baseline OM incidence and duration of PCV7 use differed between regions. In adjusted APC models, OM incidence decreased after PHiD-CV by 9.9% (95% confidence interval [CI]: 4.4; 15.1, p < .001) and PCV13 by 2.3% (95%CI: -3.2; 7.6, p = .401) compared with pre-PCV. Both PHiD-CV and PCV13 decreased the risk of first OM diagnosis: hazard ratio (95%CI) for PHiD-CV relative to pre-PCV 0.67 (0.65; 0.69); 0.87 (0.85; 0.89) for PCV13 relative to pre-PCV; p < .001 for both comparisons. Within the limitations of this study conducted in two large Swedish regions, descriptive time-series analyses showed that OM incidence rates declined following the introduction of PHiD-CV and PCV13; however, this reduction only reached statistical significance for PHiD-CV in the adjusted APC models. SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/32574101/The_effect_of_pneumococcal_conjugate_vaccines_on_otitis_media_from_2005_to_2013_in_children_aged_���������5_years:_a_retrospective_cohort_study_in_two_Swedish_regions_ L2 - https://www.tandfonline.com/doi/full/10.1080/21645515.2020.1775455 DB - PRIME DP - Unbound Medicine ER -